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Biomarkers for predicting immunotherapy response and resistance in glioblastoma
Artículo
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Biomarkers for predicting immunotherapy response and resistance in glioblastoma
Samuel Kim et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Glioblastoma is the most common and aggressive primary brain tumor in adults that fails to meet survival endpoint criteria in current immunotherapy Phase III clinical trials. As a small subset of immunotherapy-responsive...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Blood‐brain barrier dysfunction and decreased transcription of tight junction proteins in epileptic dogs
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Blood‐brain barrier dysfunction and decreased transcription of tight junction proteins in epileptic dogs
Erez Hanael et al · Oxford University Press · 2024 · ISSN 0891-6640
Abstract Background Epilepsy in dogs and humans is associated with blood‐brain barrier (BBB) dysfunction (BBBD), which may involve dysfunction of tight junction (TJ) proteins, matrix metalloproteases, and astrocytes. I...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Carcinogenicity assessment of PFOS based on weight of evidence and dose-response analysis
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Carcinogenicity assessment of PFOS based on weight of evidence and dose-response analysis
GOU Yurui et al · The Editorial Office of Chinese Journal of Food Hygiene · 2025 · ISSN 1004-8456
ObjectiveTo assess the quality of the literature related to the carcinogenicity of perfluorooctane sulfonic acid （PFOS） using the weight of evidence method， and to evaluate its carcinogenic risk through the dose-re...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Nutrition. Foods and food supplyIdioma zho
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Case Report: An interesting case of vision and hearing loss revealing CNS recurrence in Philadelphia-positive acute lymphoblastic leukemia
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Case Report: An interesting case of vision and hearing loss revealing CNS recurrence in Philadelphia-positive acute lymphoblastic leukemia
Ifeoma Ike et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
BackgroundCentral nervous system (CNS) relapse in acute lymphoblastic leukemia (ALL) may occur despite systemic remission and can present with isolated neuro-ophthalmologic symptoms. Early diagnosis may be challenging as...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Case Report: Leptomeningeal involvement in chronic lymphocytic leukemia patients with central nervous system infection: extramedullary manifestation or transmigration of leukocytes—how to treat this type of CLL?
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Case Report: Leptomeningeal involvement in chronic lymphocytic leukemia patients with central nervous system infection: extramedullary manifestation or transmigration of leukocytes—how to treat this type of CLL?
Tianjiao Zhang et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
Central nervous system (CNS) involvement by CLL is rare. We report a non-treated CLL patient with low-risk factors, but showed leptomeningeal involvement during/after neuroborreliosis and EBV meningitis. An 80-year-old w...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Cerebrospinal Fluid Concentrations of Calcitonin Gene Related Peptide in Dogs With Chiari‐Like Malformation
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Cerebrospinal Fluid Concentrations of Calcitonin Gene Related Peptide in Dogs With Chiari‐Like Malformation
John D. Macri et al · Oxford University Press · 2025 · ISSN 0891-6640
ABSTRACT Background The biomarker Calcitonin Gene‐Related Peptide (CGRP) is elevated in human conditions associated with neuropathic pain, but has not yet been studied in Cavalier King Charles Spaniels (CKCS) with Chia...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Cerebrospinal Fluid Levels of Phosphorylated Neurofilament Heavy as a Diagnostic Marker of Canine Degenerative Myelopathy
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Cerebrospinal Fluid Levels of Phosphorylated Neurofilament Heavy as a Diagnostic Marker of Canine Degenerative Myelopathy
C.M. Toedebusch et al · Oxford University Press · 2017 · ISSN 0891-6640
Background No definitive, antemortem diagnostic test for canine degenerative myelopathy (DM) is available. Phosphorylated neurofilament heavy (pNF‐H) is a promising biomarker for nervous system diseases. Hypothesis/Obj...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Clinical presentation of neurosyphilis – a single-center retrospective data analysis
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Clinical presentation of neurosyphilis – a single-center retrospective data analysis
Susanne Dyckhoff-Shen et al · BMC · 2026 · ISSN 2524-3489
Abstract Background As cases of neurosyphilis are rising worldwide – especially in people living with HIV (PLWH) – current data on clinical presentation, diagnostics and management of neurosyphilis in Europe are of h...
LCC LCC:Neurosciences. Biological psychiatry. Neuropsychiatry; LCC:Neurology. Diseases of the nervous systemIdioma eng
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Clinical presentation, treatment, and outcome of 24 dogs with bacterial meningitis or meningoencephalitis without empyema (2010‐2020)
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Clinical presentation, treatment, and outcome of 24 dogs with bacterial meningitis or meningoencephalitis without empyema (2010‐2020)
Faye Rawson et al · Oxford University Press · 2023 · ISSN 0891-6640
Abstract Background Bacterial meningitis (BM) and meningoencephalitis (BMEM) are associated with high case fatality rates and neurologic sequelae in people, but limited data exists on outcome in dogs. Hypothesis/Objectiv...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Cognitive reserve and AβI-42 in mild cognitive impairment (Argentina-Alzheimer’s disease neuroimaging initiative)
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Cognitive reserve and AβI-42 in mild cognitive impairment (Argentina-Alzheimer’s disease neuroimaging initiative)
Harris, Paula et al · Dove Press · 2015 · ISSN 2599-2604
Background: The purpose of this study was to investigate the relationship between cognitive reserve and concentration of Aβ1-42 in the cerebrospinal fluid (CSF) of patients with mild cognitive impairment, those with Alz...
Idioma eng
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Comparative assessment of heavy metal exposure and health risks in khaini and filtered khaini smokeless tobacco products
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Comparative assessment of heavy metal exposure and health risks in khaini and filtered khaini smokeless tobacco products
Arun Kumar Sundaragopal et al · Springer · 2026 · ISSN 3005-0774
Abstract Objectives Smokeless tobacco (SLT) products are widely consumed in India, contributing significantly to the burden of oral cancer and systemic diseases. Despite their popularity, limited data exist on heavy meta...
LCC LCC:Public aspects of medicineIdioma eng
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Comparison of 2 collection methods for cerebrospinal fluid analysis from standing, sedate adult horses
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Comparison of 2 collection methods for cerebrospinal fluid analysis from standing, sedate adult horses
Hayley Chidlow et al · Oxford University Press · 2020 · ISSN 0891-6640
Abstract Background Cerebrospinal fluid (CSF) analysis is an important component of the evaluation of horses with neurologic disease. Lumbosacral (LS) centesis is routine, but CSF is also collected from the space between...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Continuous Suprainguinal Fascia Iliaca Block vs Epidural Analgesia for Pediatric Hip Surgery: A Retrospective Cohort Study
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Continuous Suprainguinal Fascia Iliaca Block vs Epidural Analgesia for Pediatric Hip Surgery: A Retrospective Cohort Study
Halpern LM et al · Dove Medical Press · 2026 · ISSN 1178-7112
Lloyd M Halpern,1 Zackary Correll,2 De-An Zhang,3 Clark J Kogan,4 Kirk A Ryan,5 Ted Sousa6 1Department of Anesthesia, Shriners Children’s Hospital, Spokane, WA, USA; 2Department of Medicine, University of Washington Sc...
LCC LCC:AnesthesiologyIdioma eng
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Correlações entre as características obtidas in vivo por ultra-som e as obtidas na carcaça de cordeiros terminados em confinamento Correlations between traits obtained by real time ultrasound and those obtained in the carcass of feedlot finished lambs
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Correlações entre as características obtidas in vivo por ultra-som e as obtidas na carcaça de cordeiros terminados em confinamento Correlations between traits obtained by real time ultrasound and those obtained in the carcass of feedlot finished lambs
Felipe Queiroga Cartaxo et al · Sociedade Brasileira de Zootecnia · 2008 · ISSN 1516-3598
Avaliou-se a relação entre as características in vivo obtidas por meio de ultra-som e as obtidas na carcaça de cordeiros terminados em confinamento. Foram utilizados 48 cordeiros não-castrados, deslanados mestiços ...
LCC LCC:Animal cultureIdioma eng
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Corticosteroid monotherapy versus combined cytarabine continuous rate infusion and corticosteroid therapy in dogs with meningoencephalitis of unknown origin: A blinded, randomized, controlled trial
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Corticosteroid monotherapy versus combined cytarabine continuous rate infusion and corticosteroid therapy in dogs with meningoencephalitis of unknown origin: A blinded, randomized, controlled trial
Bethan S. Jones et al · Oxford University Press · 2024 · ISSN 0891-6640
Abstract Background Treatment options available for meningoencephalitis of unknown origin (MUO) in dogs are suboptimal, and currently, no single treatment protocol appears to be superior. Objectives Compare neurological ...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Diagnostic performance of plasma GFAP in preclinical stages of Alzheimer’s disease using the Lumipulse platform
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Diagnostic performance of plasma GFAP in preclinical stages of Alzheimer’s disease using the Lumipulse platform
Andrea Valera-Barrero et al · BMC · 2026 · ISSN 1758-9193
Abstract Background Plasma glial fibrillary acidic protein (GFAP) has emerged as a promising biomarker of astrocytic reactivity in preclinical Alzheimer´s Disease (AD). However, most evidence to date comes from ultrasen...
LCC LCC:Neurosciences. Biological psychiatry. Neuropsychiatry; LCC:Neurology. Diseases of the nervous systemIdioma eng
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Dissecting the Causal Pathway from Herpes Zoster to Postherpetic Neuralgia: A Multi-Stage Mendelian Randomization Study Implicating VZV-Specific IgE and Cerebrospinal Fluid Metabolites
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Dissecting the Causal Pathway from Herpes Zoster to Postherpetic Neuralgia: A Multi-Stage Mendelian Randomization Study Implicating VZV-Specific IgE and Cerebrospinal Fluid Metabolites
Zhang J et al · Dove Medical Press · 2026 · ISSN 1178-7090
Jianjin Zhang,1,* Yanhong Chen,1,* Xingyu Li,2,* Chaobo Feng,1 Jiapeng Li,1 Zhouyang Hu,1 Guoxin Fan,1 Xiang Liao1 1National Key Clinical Pain Medicine of China, Shenzhen Nanshan People’s Hospit...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Disseminated Fusariosis, Leukemia Cutis, and Acute Sinus Disease in Prolonged Neutropenia from Acute Myeloid Leukemia
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Disseminated Fusariosis, Leukemia Cutis, and Acute Sinus Disease in Prolonged Neutropenia from Acute Myeloid Leukemia
Katarzyna Karpinska-Leydier et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundPatients with acute myeloid leukemia (AML) and prolonged neutropenia are at high risk for invasive fungal infections such as fusariosis, which represents the second most common pathogenic mold infection in this...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Effect of calcium salts of fatty acids on the nutritive value of diets, feeding behavior, and serum blood parameters of lactating Saanen goats grazing on stargrass
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Effect of calcium salts of fatty acids on the nutritive value of diets, feeding behavior, and serum blood parameters of lactating Saanen goats grazing on stargrass
Ludmila Couto Gomes et al · Sociedade Brasileira de Zootecnia · ISSN 1806-9290
ABSTRACT The objective of this study was to determine effects of the addition of calcium salts of fatty acids (CSFA) to the concentrate on the intake and digestibility of dry matter and nutrients and the grazing behavior...
LCC LCC:Animal cultureIdioma eng
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Evaluating the additive properties of differential pressure valves in a novel benchtop shunt model
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Evaluating the additive properties of differential pressure valves in a novel benchtop shunt model
Sai Chandan Reddy et al · BMC · 2026 · ISSN 2045-8118
Abstract Objective Cerebrospinal fluid (CSF) over-drainage is an unintended sequela of using a shunt valve to treat hydrocephalus, and a second valve may be added in series to better control drainage. In this study, we t...
LCC LCC:Neurology. Diseases of the nervous systemIdioma eng
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Extended endoscopic endonasal approach for resection of suprasellar meningiomas
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Extended endoscopic endonasal approach for resection of suprasellar meningiomas
Hazem Mohamed Negm et al · SpringerOpen · 2026 · ISSN 2520-8225
Abstract Background Suprasellar meningiomas are classically removed through several different surgical transcranial approaches, including the pterional transsylvian route. Recently, the indications for the transsphenoida...
LCC TENDOlN1cmdlcnk~; LCC:Neurosciences. Biological psychiatry. NeuropsychiatryIdioma eng
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Factors associated with cerebrospinal fluid abnormalities suggestive of neurosyphilis in HIV-negative patients with secondary syphilis: a retrospective study
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Factors associated with cerebrospinal fluid abnormalities suggestive of neurosyphilis in HIV-negative patients with secondary syphilis: a retrospective study
Lin Zhu et al · Frontiers Media S.A · 2026 · ISSN 2296-858X
ObjectiveTo identify clinical and laboratory factors associated with cerebrospinal fluid (CSF) abnormalities suggestive of neurosyphilis (NS) among HIV-negative patients with secondary syphilis.MethodsWe conducted a retr...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Fatal Pneumococcal Meningitis in a 22-Month-Old with Classical Complement C2 Deficiency
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Fatal Pneumococcal Meningitis in a 22-Month-Old with Classical Complement C2 Deficiency
Mariam Eldaba et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundEarly complement pathway deficiencies predispose to invasive infections with encapsulated bacteria. C2 deficiency is the most common human complement deficiency, yet it may remain clinically silent until a life...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Granulocyte-macrophage colony-stimulating factor at work: Promoting vascular maturation for accelerated wound healing
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Granulocyte-macrophage colony-stimulating factor at work: Promoting vascular maturation for accelerated wound healing
Wenjie Ying et al · Elsevier · 2026 · ISSN 0890-8508
Background: Wound healing is a complex biological process involving vascular remodeling and tissue repair. However, the mechanism by which granulocyte-macrophage colony-stimulating factor (GM-CSF) facilitates vascular ma...
LCC LCC:Biology (General); LCC:MedicineIdioma eng
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