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Abstract Background Outcomes after curative-intent sarcoma surgery vary substantially and are incompletely explained by tumor-centered factors alone. Although CT-based body composition metrics provide objective host-rela...

Abstract Background Frailty is a known predictor of adverse surgical outcomes, yet its influence on functional recovery trajectories in South Asian settings remains underexplored. This study evaluated the association bet...

Abstract Background Pulmonary hypertension (PH) is a serious and potentially life-threatening complication of systemic lupus erythematosus (SLE). Functional characterization may facilitate the differentiation of the hete...

Background and objectives: Anterior cruciate ligament (ACL) injuries are common among individuals who lead active lifestyles. A frequently used surgical approach to address this condition is ACL reconstruction (ACLR) uti...

Hyperactivity of the hypothalamic pituitary adrenal (HPA) axis in patients with major depression is one of the most consistent findings in biological psychiatry. Experimental data support the idea that glucocorticoid-med...

We present HAlator, a fully automated quantum chemistry (QM) workflow for computing C–H hydricities and explore its potential in predicting the regioselectivity of electron-rich C–H functionalisation reactions. The w...

Abstract Background Traumatic brain injury (TBI) needs inter-disciplinary care through pre-hospital resuscitation, emergency and neurosurgical care, neurocritical care, and structured neurorehabilitation to maximize surv...

Frontal and parietal regions are associated with some of the most complex cognitive functions,and several frontoparietal resting state networks can be observed in wakefulness. We used functional magnetic resonance imagin...

Abstract Background Zanthoxylum armatum is a vital economic crop in China, but its cultivation is challenged by abiotic stresses like drought and cold. Mitogen-activated protein kinase kinases (MAPKKs) are central signal...

Abstract Background Usually Multiple Amino acids Move In and Out Transporters (UMAMITs), belonging to the MtN21/EamA-like/UMAMIT superfamily, play vital roles in amino acid transport, nodule formation, and nitrogen fixat...

Background: In multiple sclerosis (MS), chronic “smoldering” lesions are driven by microglial activation, which promotes demyelination and disease progression. However, microglia exhibit a functional dichotomy by per...

Fungi are ubiquitous across nearly all habitats and play pivotal roles in maintaining ecological sustainability. Understanding the composition and functional roles of active fungal communities is essential for elucidatin...

Abstract Background I Kappa B Kinase Interacting Protein (IKBIP) has been reported to promote tumor progression in diverse cancers. however, the role of IKBIP in hepatocellular carcinoma (HCC) has remained unclear. Metho...

Abstract A first-principles study of the structural, electronic, magnetic, mechanical, and optical properties of the double perovskite Ca₂GaAsO₆ is presented using density functional theory with the Perdew-Burke-Ernz...

BackgroundGlioblastoma (GBM) remains a lethal brain tumor with limited therapeutic options and near-universal recurrence. Drug repurposing offers a practical strategy, but pleiotropic compounds require systematic target ...

Abstract Silver nanoparticles (AgNPs) have gained relevance in restorative dentistry due to their antimicrobial and remineralizing properties. However, the role of AgNPs functionalized with different polyphenols in denti...

PurposeThis study aimed to investigate the associations between gut metabolites Trimethylamine N-Oxide (TMAO), the novel platelet-derived inflammatory ratio index neutrophil-to-platelet ratio (NPR), and the prognosis of ...

Background. Proximal humerus fractures (PHFs) represent approximately 5% of all fractures, occurring predominantly in elderly patients with osteoporosis. Functional limitations and high complication rates are common resu...

Ziyuan Shen,1 Xing Xing,2 Kang Rong,3 Ziyang Geng,4 Ning Yang,5 Linyan Xu,3,6 Hongfeng Ge,7 Wei Sang3,6,8 1Clinical Research Institute, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Re...

Abstract Background The complex relationship between the gut microbiome and immune system development during infancy is considered a key factor in the rising rates of pediatric allergic diseases. Food protein-induced all...

ObjectiveTo systematically map the evolution, academic network structure, and emergent research fronts of functional magnetic resonance imaging (fMRI) applications in prolonged disorders of consciousness (pDoC) through b...

Abstract Spatial variations in stiffness and mass density make the free-vibration behavior of tridirectionally functionally graded material (3D-FGM) beams highly sensitive to material gradation, while computationally eff...

Carbonyl sulfide (COS) is a dangerous gas produced from fossil fuel combustion and petrochemical procedures, so proper adsorbent and sensors are required for removal and detection. In this work, we study by Density Funct...

Nowadays, modern software development processes follow an iterative approach, which makes possible to start the testing of a system at early stages. This approach requires recording the requirements artifacts that specif...