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Abstract Background Outcomes after curative-intent sarcoma surgery vary substantially and are incompletely explained by tumor-centered factors alone. Although CT-based body composition metrics provide objective host-rela...

Abstract Background Frailty is a known predictor of adverse surgical outcomes, yet its influence on functional recovery trajectories in South Asian settings remains underexplored. This study evaluated the association bet...

Objective Endometriosis (EMs) is a chronic gynaecological condition characterised by the ectopic growth of endometrial tissue; however, its molecular mechanisms remain insufficiently understood. Ferroptosis, an iron-depe...

Abstract Background Pulmonary hypertension (PH) is a serious and potentially life-threatening complication of systemic lupus erythematosus (SLE). Functional characterization may facilitate the differentiation of the hete...

Background and objectives: Anterior cruciate ligament (ACL) injuries are common among individuals who lead active lifestyles. A frequently used surgical approach to address this condition is ACL reconstruction (ACLR) uti...

Hyperactivity of the hypothalamic pituitary adrenal (HPA) axis in patients with major depression is one of the most consistent findings in biological psychiatry. Experimental data support the idea that glucocorticoid-med...

Abstract Slaughterhouse blood is a by-product of animal slaughter that can be a good source of animal protein. This research purposed to examine the functional qualities of the blood plasma from Hanwoo cattle, black goat...

We present HAlator, a fully automated quantum chemistry (QM) workflow for computing C–H hydricities and explore its potential in predicting the regioselectivity of electron-rich C–H functionalisation reactions. The w...

Abstract Background Subjective cognitive decline and mild cognitive impairment represent critical windows for intervention as early stages of dementia progression. Although digital health interventions have shown potenti...

Relevance. Age-related macular degeneration (AMD) and glaucoma are currently the main causes of irreversible vision loss in developed countries. Purpose. To study the epidemiological and clinical-functional aspects of ...

Abstract Background/objectives Cardiovascular diseases (CVDs), particularly myocardial infarction (MI) and heart failure (HF), remain global causes of morbidity and mortality, despite the current treatment options. Stem ...

Abstract Background Traumatic brain injury (TBI) needs inter-disciplinary care through pre-hospital resuscitation, emergency and neurosurgical care, neurocritical care, and structured neurorehabilitation to maximize surv...

Frontal and parietal regions are associated with some of the most complex cognitive functions,and several frontoparietal resting state networks can be observed in wakefulness. We used functional magnetic resonance imagin...

Abstract Background Usually Multiple Amino acids Move In and Out Transporters (UMAMITs), belonging to the MtN21/EamA-like/UMAMIT superfamily, play vital roles in amino acid transport, nodule formation, and nitrogen fixat...

Fungi are ubiquitous across nearly all habitats and play pivotal roles in maintaining ecological sustainability. Understanding the composition and functional roles of active fungal communities is essential for elucidatin...

Abstract Background I Kappa B Kinase Interacting Protein (IKBIP) has been reported to promote tumor progression in diverse cancers. however, the role of IKBIP in hepatocellular carcinoma (HCC) has remained unclear. Metho...

Abstract A first-principles study of the structural, electronic, magnetic, mechanical, and optical properties of the double perovskite Ca₂GaAsO₆ is presented using density functional theory with the Perdew-Burke-Ernz...

BackgroundGlioblastoma (GBM) remains a lethal brain tumor with limited therapeutic options and near-universal recurrence. Drug repurposing offers a practical strategy, but pleiotropic compounds require systematic target ...

Abstract Silver nanoparticles (AgNPs) have gained relevance in restorative dentistry due to their antimicrobial and remineralizing properties. However, the role of AgNPs functionalized with different polyphenols in denti...

PurposeThis study aimed to investigate the associations between gut metabolites Trimethylamine N-Oxide (TMAO), the novel platelet-derived inflammatory ratio index neutrophil-to-platelet ratio (NPR), and the prognosis of ...

Background. Proximal humerus fractures (PHFs) represent approximately 5% of all fractures, occurring predominantly in elderly patients with osteoporosis. Functional limitations and high complication rates are common resu...

Ziyuan Shen,1 Xing Xing,2 Kang Rong,3 Ziyang Geng,4 Ning Yang,5 Linyan Xu,3,6 Hongfeng Ge,7 Wei Sang3,6,8 1Clinical Research Institute, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Re...

Abstract Background The complex relationship between the gut microbiome and immune system development during infancy is considered a key factor in the rising rates of pediatric allergic diseases. Food protein-induced all...

STAT1 gain-of-function (GoF) is an inborn error of immunity characterized by a common feature of chronic mucocutaneous candidiasis and variable additional clinical manifestations, including recurrent bacterial and viral ...