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Abstract Background In photosynthetic eukaryotes of the green lineage, the expression of the chloroplast genome is mainly regulated post-transcriptionally, by RNA-binding proteins encoded in the nuclear genome termed org...

Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by heterogeneity in its genetic, epigenetic, and environmental etiologies, posing significant challenges for therapeutic development...

Materias / palabras clave: CRISPR; Genome engineering; Cas9; Genome editing; Guide RNA; Biology; Computational biology; Nuclease; Genome; Homology directed repair; Synthetic biology; Non-homologous end joining

Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats)/Cas adaptive immune ...

Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that use short RNA to direct degradation of foreign n...

The use of some multiple-sequence alignments in phylogenetic analysis, particularly those that are not very well conserved, requires the elimination of poorly aligned positions and divergent regions, since they may not b...

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems provide bacteria and archaea with adaptive immunity against viruses and plasmids by using CRISPR RNAs (crRNAs) to guide t...

Materias / palabras clave: biosystems design, genome editing, synthetic genomics, biodesign theory, biological engineering, biodesign applications; Technology: Chemical technology: Biotechnology; Science: Biology (General): Genetics

Materias / palabras clave: sequencing technologies, genome editing and genome engineering, imaging technologies, single-molecule methods, computational methods, machine learning; Technology: Chemical technology: Biotechnology; Science: Chemistry: ...

Materias / palabras clave: synthetic biology, metabolic engineering, natural products, enzyme engineering, biosystems engineering, genome editing; Technology: Chemical technology: Biotechnology; Science: Biology (General)