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Temporal analysis of two inducible human genes reveals that H3K4me3 is uncoupled from transcriptional initiation, acting as a post-transcriptional mark rather than a driver of induction. Histone H3 lysine 4 trimethylatio...

Aims. Posttranslational modifications of histones and transcription factors regulate gene expression and are implicated in beta-cell failure and diabetes. We have recently shown that preserving H3K27 and H3K4 methylation...

Chromatin, the physiological template of all eukaryotic genetic information, is subject to a diverse array of posttranslational modifications that largely impinge on histone amino termini, thereby regulating access to th...

Materias / palabras clave: Chromatin; Biology; Histone; Nucleosome; Histone-modifying enzymes; DNA; Non-histone protein; Cell biology; Histone code; ChIA-PET; Genetics; Function (biology)

Tumor development is the result of genetic and epigenetic alterations. The epigenetic mechanisms do not imply a change in the DNA sequence but can be as important as the genetic mechanisms for the onset and progression o...

The GABAergic neurotransmission is a highly conserved system that has been attributed to various regulatory events. There has been a notable number of studies on the importance of GABAergic neurotransmission, both excita...

Materias / palabras clave: epigenetics, epigenomics, histone modifications, dna methylation, dna demethylation; Science: Biology (General): Genetics

Materias / palabras clave: epigenetics, dna methylation, histone modification, non-coding rna, epigenomics, paramutation; Science: Biology (General); Medicine