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Exosome-mediated delivery of miRNA-1290 inhibitor enhances JNK-dependent tissue-resident memory T cell immunity in prostate cancer

Exosome-mediated delivery of miRNA-1290 inhibitor enhances JNK-dependent tissue-resident memory T cell immunity in prostate cancer

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Bin Liang et al · Nature Portfolio · 2026 · ISSN 2045-2322

Abstract Prostate cancer (PCa) is a leading malignancy in men, particularly challenging in its advanced stages due to treatment resistance and immune evasion. MicroRNA-1290 (miR-1290) was identified to be implicated in t...

LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng

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HEM-1-Associated Inborn Error of Immunity: A Case Series

HEM-1-Associated Inborn Error of Immunity: A Case Series

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Sebastian Chamorro Ordonez et al · Rockefeller University Press · 2026 · ISSN 3065-8993

NCKAP1L encodes hematopoietic protein-1 (HEM1), a component of the WASp family verproline-homologous protein (WAVE) actin regulatory complex, activated downstream of multiple immune receptors. HEM1 deficiency disrupts WA...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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Immunogenetic Screening Reveals Hidden Inborn Errors of Immunity in Pediatric Lymphoproliferative Disorders

Immunogenetic Screening Reveals Hidden Inborn Errors of Immunity in Pediatric Lymphoproliferative Disorders

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Martina Burattin et al · Rockefeller University Press · 2026 · ISSN 3065-8993

Background and AimsPediatric lymphoproliferative disorders (LPD), both malignant and nonmalignant, may conceal underlying inborn errors of immunity (IEI), yet systematic screening is rarely performed. We hypothesized tha...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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Impact and Perspectives of Registry-Based Research in Inborn Errors of Immunity/Primary Immune Disorders: Insights from the ESID Registry of 36,681 Patients

Impact and Perspectives of Registry-Based Research in Inborn Errors of Immunity/Primary Immune Disorders: Insights from the ESID Registry of 36,681 Patients

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Markus G. Seidel · Rockefeller University Press · 2026 · ISSN 3065-8993

Clinical research and real-world observational studies are essential for advancing the diagnosis and treatment of rare diseases, such as inborn errors of immunity/primary immune disorders (IEI/PID). To support efficient ...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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Inborn Errors of Immunity Adolescents at School

Inborn Errors of Immunity Adolescents at School

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Jacques G. Rivière et al · Rockefeller University Press · 2026 · ISSN 3065-8993

BackgroundAdolescents with inborn errors of immunity (IEI) experience disease-related absenteeism and psychosocial challenges that can compromise schooling. Evidence integrating perspectives across stakeholders is limite...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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Innovations in Care of Inborn Errors of Immunity in Brazil: CNE3I, the Brazilian National Center for Inborn Errors of Immunity and Immune Dysregulation Diseases

Innovations in Care of Inborn Errors of Immunity in Brazil: CNE3I, the Brazilian National Center for Inborn Errors of Immunity and Immune Dysregulation Diseases

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Leonardo Mendonca et al · Rockefeller University Press · 2026 · ISSN 3065-8993

Inborn errors of immunity (IEI), once considered rare, are more common than previously thought, affecting up to 1:1000 individuals, with 555 IEI identified involving variants in 546 genes. This expanded genetic and clini...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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Introducing the MIRACLE Task Force: Maternal Immunity, Reproduction, and Inborn Errors of Immunity Collaboration

Introducing the MIRACLE Task Force: Maternal Immunity, Reproduction, and Inborn Errors of Immunity Collaboration

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Jessica Galant-Swafford et al · Rockefeller University Press · 2026 · ISSN 3065-8993

IntroductionThe MIRACLE Task Force is a multidisciplinary, multi-institutional work group comprising immunology, genetics, obstetrics/gynecology, and maternal fetal medicine providers dedicated to understanding reproduct...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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Malignancy Is Associated with Disorders of Immunity in a Large U.S. Cohort: An All of Us Research Program Study

Malignancy Is Associated with Disorders of Immunity in a Large U.S. Cohort: An All of Us Research Program Study

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Derek MacMath et al · Rockefeller University Press · 2026 · ISSN 3065-8993

BackgroundAlthough the association between disorders of immunity and cancer risk is recognized, the prevalence of different malignancies in this population remains incompletely characterized. Large electronic health reco...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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Metabolic control of immunity and inflammation: Mitochondrial dynamics, pharmacological targets, and therapeutic opportunities

Metabolic control of immunity and inflammation: Mitochondrial dynamics, pharmacological targets, and therapeutic opportunities

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Chunling Wang et al · Elsevier · 2026 · ISSN 1096-1186

Immune responses and inflammation are not stand-alone processes linearly regulated by the canonical signaling pathways but complex systems biology events, which are deeply rooted in the metabolic state of cells and dynam...

LCC LCC:Therapeutics. PharmacologyIdioma eng

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Newborn Screening Inborn Errors of Immunity in the Republic of Belarus: The First Pilot Study

Newborn Screening Inborn Errors of Immunity in the Republic of Belarus: The First Pilot Study

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E.A. Polyakova et al · Rockefeller University Press · 2026 · ISSN 3065-8993

Background and AimsThe primary focus of neonatal screening is the early detection of asymptomatic infants with a range of serious diseases for which effective treatment is available and for which early diagnosis and inte...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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Prospective Clinical Trial of Mycophenolate Mofetil (MMF) Duration De-Escalation in Allogeneic Hematopoietic Cell Transplantation (HCT) for Inborn Errors of Immunity: Is MMF Dispensable After Reduced Intensity Conditioning, Posttransplantation Cyclophosphamide(Ptcy)-Based HCT?

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Dimana Dimitrova et al · Rockefeller University Press · 2026 · ISSN 3065-8993

Hematopoietic cell transplantation (HCT) offers curative potential for inborn errors of immunity (IEI) patients, who often enter HCT with significant comorbidities and disease sequelae, active infections, and/or limited ...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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Selective IgM Deficiency with Combined Lymphocyte Abnormalities and Aortic Root Dilation: A Potential Novel Inborn Error of Immunity

Selective IgM Deficiency with Combined Lymphocyte Abnormalities and Aortic Root Dilation: A Potential Novel Inborn Error of Immunity

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Aashna Thakur et al · Rockefeller University Press · 2026 · ISSN 3065-8993

BackgroundRecurrent bacterial pneumonia accompanied by atypical systemic findings may indicate an uncharacterized inborn error of immunity (IEI). We report a 10-year-old male with recurrent pneumonias, mildly low but fun...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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Targeting the TIGIT/CD155-induced metabolic checkpoint in NK cells restores anti-tumor immunity and suppresses hepatocellular carcinoma growth

Targeting the TIGIT/CD155-induced metabolic checkpoint in NK cells restores anti-tumor immunity and suppresses hepatocellular carcinoma growth

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Jiaojie Shu et al · Frontiers Media S.A · 2026 · ISSN 1664-3224

BackgroundThe TIGIT/CD155 axis is a key immune checkpoint in hepatocellular carcinoma (HCC), but its role in regulating natural killer (NK) cell metabolism and function remains unclear. This study investigates how this a...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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The effect of pegbovigrastim administration on the nonspecific immunity of calves

The effect of pegbovigrastim administration on the nonspecific immunity of calves

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Katarzyna Dudek et al · Oxford University Press · 2024 · ISSN 0891-6640

Abstract Background Prevention of diseases in the early rearing of calves is important, particularly because disease occurrence most often requires antimicrobial administration but reduction of their use in animals is a ...

LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng

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Tick saliva reprograms macrophages into immunosuppressive hubs that regulate T-cell immunity in Rhipicephalus microplus infestation

Tick saliva reprograms macrophages into immunosuppressive hubs that regulate T-cell immunity in Rhipicephalus microplus infestation

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Hayato Nakamura et al · Nature Portfolio · 2026 · ISSN 2399-3642

Abstract Ticks transmit diverse pathogens and secrete saliva with immunomodulatory properties that facilitates blood feeding. However, the cellular mechanisms underlying saliva-mediated immune suppression remain poorly d...

LCC LCC:Biology (General)Idioma eng

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Dendritic cells and the control of immunity

Dendritic cells and the control of immunity

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Jacques Banchereau; Ralph M. Steinman · Nature · 1998

Materias / palabras clave: Immune system; Antigen; Cell biology; Dendritic cell; Antigen-presenting cell; Biology; Immunology; Antigen presentation; Secretion; Immunity; Acquired immune system; Innate lymphoid cell

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Pathogen Recognition and Innate Immunity

Pathogen Recognition and Innate Immunity

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Shizuo Akira; Satoshi Uematsu; Osamu Takeuchi · Cell · 2006

Materias / palabras clave: Biology; Innate immune system; Pattern recognition receptor; Immune system; Immune receptor; Autoimmunity; Receptor; Immunity; Immunology; Innate lymphoid cell; Acquired immune system; Pathogen-associated molecular patte...

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

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Taro Kawai; Shizuo Akira · Nature Immunology · 2010

Materias / palabras clave: Innate immune system; Pattern recognition receptor; Biology; Acquired immune system; Receptor; Immunology; Immune system; Immunity; Toll-like receptor; Pathogen-associated molecular pattern; Cell biology; Neuroscience

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A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

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Martin Jínek; Krzysztof Chylinski; Ines Fonfara; M. Hauer; Jennifer A. Doudna; Emmanuelle Charpentier · Science · 2012

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems provide bacteria and archaea with adaptive immunity against viruses and plasmids by using CRISPR RNAs (crRNAs) to guide t...

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A review on phytochemical and bacteriophage based therapeutic strategies for the management of Brucellosis

A review on phytochemical and bacteriophage based therapeutic strategies for the management of Brucellosis

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Rajshree Vidyashankar et al · Frontiers Media S.A · 2026 · ISSN 2297-1769

Brucellosis, a zoonotic disease, triggers severe inflammation and reproductive complications in both humans and animals. The standard treatment protocol relies on prolonged antibiotic courses, often combining streptomyci...

LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng

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Analysis of immune-related alterations in blood and spinal cord of canine degenerative myelopathy, a spontaneous model of amyotrophic lateral sclerosis

Analysis of immune-related alterations in blood and spinal cord of canine degenerative myelopathy, a spontaneous model of amyotrophic lateral sclerosis

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Shunya Yokota et al · Nature Portfolio · 2026 · ISSN 2045-2322

Abstract Canine degenerative myelopathy (DM) is an adult-onset neurodegenerative disease considered a spontaneous model of human amyotrophic lateral sclerosis (ALS). Neuroinflammation occurs in both DM and ALS, and cross...

LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng

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Chronic hypoxia modulates vaccine adjuvant-induced specific immune responses: QML maintains stability while CpG significantly enhances

Chronic hypoxia modulates vaccine adjuvant-induced specific immune responses: QML maintains stability while CpG significantly enhances

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ZHANG Miaomiao et al · Editorial Office of Journal of Army Medical University · 2026 · ISSN 2097-0927

Abstract Objective High-altitude chronic hypoxia can alter the immune status, yet the immune regulatory characteristics of various vaccine adjuvants in this environment remain to be fully elucidated. Accordingly, emph...

LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma zho

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Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma

Detection and characterization of Fosfolipase A2 (PLA2) in Caiman latirostris and Caiman yacare plasma

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Siroski, Pablo Ariel et al · Zoological Society of Japan · 2013 · ISSN 0289-0003

Reptiles proved to have a versatile and efficient nonspecific immune system adapted to the environment where they commonly live. Phospholipase A2 (PLA2) is important hydrolytic enzyme involved in the regulation of specif...

Idioma eng

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