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Cancer-associated fibroblasts (CAFs) are one of the main components of the tumor microenvironment (TME) of solid tumors. They have several functions, which all contribute to tumor growth and immune evasion. CAF presence ...

ABSTRACT Purpose: The combination of radiotherapy and immunotherapy (radioimmunotherapy) shows promising antitumor efficacy but raises cardiotoxicity concerns. The underlying mechanisms remain unclear. Methods: Preclinic...

ObjectiveDespite the widespread use of immune checkpoint inhibitors (ICIs) improving survival outcomes in non-small cell lung cancer (NSCLC) patients, immune-related adverse events (irAEs) triggered by ICIs have become a...

The provision of T cell co-stimulation via members of the TNFR super-family, including OX40 (CD134) and 4-1BB (CD137), provides critical signals that promote T cell survival and differentiation. Recent studies have demon...

BackgroundImmune checkpoint blockade (ICB) has improved outcomes for a subset of colorectal cancer (CRC) patients, yet the cellular determinants that drive heterogeneous treatment responses remain insufficiently understo...

Abstract Background Non-small-cell lung cancer (NSCLC) exhibits pronounced molecular heterogeneity, and current predictive models rarely incorporate mitochondrial quality-control programs such as mitophagy. We hypothesiz...

IntroductionImmune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have expanded treatment options for hepatocellular carcinoma (HCC), yet only a subset of patients achieves durable responses. Limited efficacy...

Abstract T cell states are prognostic in different cancer types. Recent technologies enable joint profiling of T cell RNA and T cell receptor (TCR) sequences at single-cell resolution. Here we present the TCR-RNA Integra...

Abstract Background Bacterial cancer therapies have regained attention as a strategy to remodel the immunosuppressive tumor microenvironment (TME). Engineered bacteria equipped with tumor-targeting moieties can enhance i...

Materias / palabras clave: Immune system; Immunotherapy; Immune checkpoint; Immunology; Antigen; Blockade; Biology; Cancer immunotherapy; Immunity; Cytotoxic T cell; Peripheral tolerance; Collateral damage

Tesis de Doctorado El bloqueo de los puntos de control como CTLA-4 y PD-1/PD-L1 ha demostrado la actividad de efectores inmunes antitumorales, por lo que ha aumentado el interés en el desarrollo de inmunoterapias contra...

Materias / palabras clave: tumour immunology, cancer immunotherapy, immunotherapy biomarkers; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens

Materias / palabras clave: immunotherapy, precision medicine, oncology, cancer, targeted therapy; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Medicine: Internal medicine: Specialties of internal medi...

Materias / palabras clave: vaccinology, immunotherapy, infectious diseases, chronic diseases, cancer; Medicine: Therapeutics. Pharmacology; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Lung cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related death worldwide. Hypoxia and histone lactylation are emerging regulators of tumor progression and immune escape. However...

Abstract Background The therapeutic efficacy of programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors in lung cancer management remains suboptimal. Sporoderm-removed Ganoderma Lucidum Spore Pow...

Hepatocellular carcinoma (HCC) remains the dominant histologic subtype of primary liver cancer and a major cause of cancer mortality worldwide. Its epidemiology continues to evolve, with metabolic dysfunction-associated ...

Aleksander Kielbik,1– 3 Veronika Bahlinger,3,4 Christian M Schürch,3,4 Maria Luisa Barcena,2 Olesya Vakhrusheva,2 Anita Thomas,5 Igor Tsaur,2 Jonas S Heitmann,1,3 Helmut R Salih,1,3,6 Ilona Hagelstein1,3,6 1Clinical C...

Transdifferentiated melanoma is a rare variant of melanoma characterized by phenotypic plasticity, loss of conventional melanocytic markers, and acquisition of features from other tissue lineages, often associated with a...

Adrenocortical carcinoma (ACC) is a rare malignancy with limited therapeutic options following the failure of standard adjuvant therapies. We present a 54-year-old female with stage IV cortisol-secreting ACC that progres...

Xiaoying Quan, Lei Lei, Xiaoyan Chen, Xiaoli Jia, Chunzhi Wu, Bin Ye, Qiyue Huang, Min Luo, Ning Wang, Jiayang Yu, Lifu Feng Department of Medical Oncology, the Sixth People’s Hospital of Chengdu, Chengdu, Sichuan, 610...

Pediatric cancer poses a major health challenge globally, especially in low-middle-income countries like Indonesia. The survival rate of pediatric cancer in many high-income countries (HICs) reaches 90%, while it only ra...

Cancer-associated fibroblasts (CAFs) are important stromal cells in the tumor microenvironment of lung adenocarcinoma (LUAD). This review discusses the different cellular sources of CAFs and the main signaling pathways i...

NK cells-based cancer therapy combined with chemotherapeutic drugs for the treatment of tumors can enhance the immunosensitivity of NK cells, increase the expression of NK cell receptors, and eventually boost the killing...