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Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
David E. Kleiner; Elizabeth M. Brunt; Mark L. Van Natta; Cynthia Behling; Melissa J. Contos; Oscar W. Cummings; Linda D. Ferrell; Yao‐Chang Liu · Hepatology · 2005
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in the absence of a history of significant alcohol use or other known liver disease. Nonalcoholic steatohepatitis (NASH) is the progressive f...
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Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes
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Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes
Zobair M. Younossi; Aaron B. Koenig; Dinan Abdelatif; Yousef Fazel; Linda Henry; Mark Wymer · Hepatology · 2015
UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver disease worldwide. We estimated the global prevalence, incidence, progression, and outcomes of NAFLD and nonalcoholic steatohepatitis (NASH)....
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Disease-derived liver organoids as a preclinical screening platform identify Sargassum japonica as an anti-fibrotic candidate
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Disease-derived liver organoids as a preclinical screening platform identify Sargassum japonica as an anti-fibrotic candidate
Jiyoung Heo et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Liver fibrosis remains an unmet medical need with limited therapeutic options and high translational failure. Conventional two-dimensional stellate cell cultures and cytokine-induced organoids poorly recapitulat...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Liver Conditions Specific to Pregnancy: Optimizing Management and Outcomes
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Liver Conditions Specific to Pregnancy: Optimizing Management and Outcomes
Alexandra Frolkis et al · Turkish Society of Gastroenterology · 2026 · ISSN 2148-5607
Pregnancy is accompanied by complex physiological adaptations that influence hepatic metabolism, bile transport, coagulation, and immune tolerance, which may precipitate the development of pregnancy-specific liver disord...
LCC LCC:Diseases of the digestive system. GastroenterologyIdioma eng
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Liver cirrhosis associated with double heterozygosity for genetic hemochromatosis (H63D) and alpha-1 antitrypsin deficiency (M-Malton) – A case report
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Liver cirrhosis associated with double heterozygosity for genetic hemochromatosis (H63D) and alpha-1 antitrypsin deficiency (M-Malton) – A case report
Gavino Faa et al · Hygeia Press di Corridori Marinella · 2026 · ISSN 2281-0692
Genetic hemochromatosis (GH) and alpha-1 antitrypsin (AAT) deficiency (AATD)  are two autosomal recessive disorders associated with an increased risk for liver injury. Among different AATD and GH genotypes, the M-Malton...
LCC LCC:Medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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A Different Etiology of Pre and Post Transplant Period Proteinuria in a Liver Transplant Patient with Wilson’s Disease
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A Different Etiology of Pre and Post Transplant Period Proteinuria in a Liver Transplant Patient with Wilson’s Disease
Eda ALTUN et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
Wilson disease (WD) is an autosomal recessive inherited disease caused by abnormalities of the copper-transporting protein encoding gene ATP7B. Wilson’s disease can cause various types of renal involvement. We present ...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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AI-powered ultrasound radiofrequency analysis for non-invasive pediatric liver fat quantification
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AI-powered ultrasound radiofrequency analysis for non-invasive pediatric liver fat quantification
Gayoung Choi et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) affects 30–50% of obese children, yet accurate non-invasive quantification remains challenging. While magnetic resonance imaging-proton density ...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Untargeted metabolomic profiling of serum from dogs with chronic hepatic disease
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Untargeted metabolomic profiling of serum from dogs with chronic hepatic disease
Yuri A. Lawrence et al · Oxford University Press · 2019 · ISSN 0891-6640
Abstract Background Chronic hepatopathies present a diagnostic challenge, with different diseases being associated with similar clinical and laboratory findings. Characterization of dogs with chronic hepatopathies can be...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Carnitine metabolic disorders and novel clinical approaches: Mechanistic insights from deficiency management to liver and kidney disease treatment
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Carnitine metabolic disorders and novel clinical approaches: Mechanistic insights from deficiency management to liver and kidney disease treatment
Mingkang Zhang et al · Elsevier · 2026 · ISSN 1756-4646
Mitochondrial dysfunction can lead to the accumulation of fatty acids and excessive production of reactive oxygen species (ROS), ultimately resulting in impaired energy production. Carnitine is essential for transporting...
LCC LCC:Nutrition. Foods and food supplyIdioma eng
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Análise morfológica dos fígados e rins no binômio materno-fetal após tratamento de ratas prenhes com Ritonavir durante toda a prenhez Morphological analysis of liver and kidneys of pregnant rats and their fetuses upon chronic Ritonavir administration
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Análise morfológica dos fígados e rins no binômio materno-fetal após tratamento de ratas prenhes com Ritonavir durante toda a prenhez Morphological analysis of liver and kidneys of pregnant rats and their fetuses upon chronic Ritonavir administration
Adelino Moreira de Carvalho et al · Federação Brasileira das Sociedades de Ginecologia e Obstetrícia · 2007 · ISSN 0100-7203
OBJETIVO: avaliar os efeitos da administração crônica de três diferentes doses de Ritonavir nos fígados e rins de ratas prenhes e seus conceptos do ponto de vista morfológico. MÉTODOS: Quarenta ratas albinas EPM-1...
LCC TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~Idioma eng
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Ablative stereotactic MR-guided radiotherapy for >10 cm solid pseudopapillary tumor of the pancreas with liver oligometastases: a case report and literature review
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Ablative stereotactic MR-guided radiotherapy for >10 cm solid pseudopapillary tumor of the pancreas with liver oligometastases: a case report and literature review
Robert A. Herrera et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
BackgroundSolid pseudopapillary tumors (SPTs) of the pancreas are rare, low-grade malignancies that generally have favorable outcomes when diagnosed at an early stage and can be resected. However, treatment options for p...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Assessing Liver and Iron Markers in Steady State Pediatric SCD Patients to Ascertain the Hepatic Consequences of Hemotransfusion: A Case‐Control Study in Ghana
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Assessing Liver and Iron Markers in Steady State Pediatric SCD Patients to Ascertain the Hepatic Consequences of Hemotransfusion: A Case‐Control Study in Ghana
John Agyemang Sah et al · Wiley · 2026 · ISSN 2398-8835
ABSTRACT Background and Aims Between 200,000 and 300,000 children with sickle cell disease (SCD) are born in Africa every year, with 75%–80% of these children living in sub‐Saharan Africa. In newborns with SCD, signi...
LCC LCC:MedicineIdioma eng
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Assessing the impact of comorbid type 2 diabetes mellitus on the disease burden of chronic hepatitis B virus infection and its complications in China from 2006 to 2030: a modeling study
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Assessing the impact of comorbid type 2 diabetes mellitus on the disease burden of chronic hepatitis B virus infection and its complications in China from 2006 to 2030: a modeling study
Jinzhao Xie et al · KeAi Communications Co., Ltd · 2024 · ISSN 2397-0642
Abstract Background China bears a high burden of both hepatitis B virus (HBV) infection and type 2 diabetes mellitus (T2DM). T2DM accelerates the progression of liver disease among individuals infected with HBV. This stu...
LCC LCC:Public aspects of medicineIdioma eng
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Extracellular vesicles derived from live or apoptotic mesenchymal stem cells: comparison of the effects of two extracellular vesicles on liver fibrosis
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Extracellular vesicles derived from live or apoptotic mesenchymal stem cells: comparison of the effects of two extracellular vesicles on liver fibrosis
Ruobing Ju et al · BMC · 2026 · ISSN 1471-230X
Abstract Background Mesenchymal stem cells (MSCs) have become a promising treatment of liver fibrosis which is a key process in liver diseases. Recent studies have shown that transplanted MSCs undergo rapid apoptosis and...
LCC LCC:Diseases of the digestive system. GastroenterologyIdioma eng
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Fatty Liver Is Associated with Transcriptional Downregulation of Stearoyl-CoA Desaturase and Impaired Protein Dimerization
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Fatty Liver Is Associated with Transcriptional Downregulation of Stearoyl-CoA Desaturase and Impaired Protein Dimerization
Fernandez Gianotti, Tomas et al · Public Library Science · 2013 · ISSN 1932-6203
AIMS AND METHODS: We evaluated the modulation of liver stearoyl-CoA desaturase-1 (Scd1) by dietary factors and insulin resistance (IR) in two experimental models of high-fat diet (HFD)-induced nonalcoholic fatty liver...
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Fine-tuned lightweight language models for structured extraction of liver cancer imaging free-text report: a comparative analysis with existing large language models
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Fine-tuned lightweight language models for structured extraction of liver cancer imaging free-text report: a comparative analysis with existing large language models
Yang-Di Luo et al · BMC · 2026 · ISSN 1471-2342
Abstract Background Organizing free-text patient data into a structured format is labor-intensive and time-consuming. This study aims to evaluate the effectiveness of a fine-tuned lightweight language model in structurin...
LCC TENDOk1lZGljYWwgdGVjaG5vbG9neQ~~Idioma eng
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Gut microbiota–intestinal barrier crosstalk: mechanistic advances, disease relevance, and public health implications
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Gut microbiota–intestinal barrier crosstalk: mechanistic advances, disease relevance, and public health implications
Changmei Chen et al · Frontiers Media S.A · 2026 · ISSN 2296-2565
BackgroundThe intestinal barrier is a critical interface between the host and the external environment, and growing evidence indicates that bidirectional crosstalk between the gut microbiota and the intestinal barrier is...
LCC LCC:Public aspects of medicineIdioma eng
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Integrating bulk RNA-seq and ScRNA-seq to identify manganese metabolism-related subtypes and immunoregulatory mechanisms in liver hepatocellular carcinoma
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Integrating bulk RNA-seq and ScRNA-seq to identify manganese metabolism-related subtypes and immunoregulatory mechanisms in liver hepatocellular carcinoma
Liu Chunhui et al · De Gruyter · 2026 · ISSN 2391-5412
Liver hepatocellular carcinoma (LIHC) is an aggressive cancer associated with chronic liver disease, necessitating better biomarkers and therapies. Manganese, an essential trace element, regulates tumor development. Data...
LCC LCC:Biology (General)Idioma eng
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Prevalence of liver disorders in children and adolescents with type 1 diabetes mellitus
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Prevalence of liver disorders in children and adolescents with type 1 diabetes mellitus
Mirna Natalija Anicic et al · BMC · 2025 · ISSN 1471-2431
Abstract Background Children and adolescents with type 1 diabetes mellitus (T1DM) occasionally develop liver disorders. Glycogenic hepatopathy and non-alcoholic fatty liver disease are the most common conditions found in...
LCC TENDOlBlZGlhdHJpY3M~Idioma eng
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Therapeutic role of JAK inhibitors in hepatogastrointestinal diseases
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Therapeutic role of JAK inhibitors in hepatogastrointestinal diseases
Maged Tharwat Elghannam et al · Open Exploration Publishing Inc · 2026 · ISSN 2833-6321
Janus kinase (JAK) inhibitors represent a major advancement in the management of immune-mediated inflammatory diseases. A balanced approach that carefully weighs therapeutic benefits against potential risks is essential....
LCC LCC:Diseases of the digestive system. GastroenterologyIdioma eng
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URINARY N-ACETYL β-D GLUCOSAMINIDASE AS AN INDICATOR OF RENAL INJURY IN PATIENTS WITH LIVER CIRRHOSIS
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URINARY N-ACETYL β-D GLUCOSAMINIDASE AS AN INDICATOR OF RENAL INJURY IN PATIENTS WITH LIVER CIRRHOSIS
İ. SÜLEYMANLAR et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
In this study, the importance of urinary N-acetyl β-u glucosaminidase (NAG) as an index of renal injury was assessed inpatients with liver cirrhosis. The study was carried out on 14 cirrhotic patients without primary ...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Antigen-specific tolerance and control of autoimmunity effected by liver sinusoidal endothelial cells is unimpaired in liver fibrosis
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Antigen-specific tolerance and control of autoimmunity effected by liver sinusoidal endothelial cells is unimpaired in liver fibrosis
Cornelia Gottwick et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Background and aimsLiver sinusoidal endothelial cells (LSECs) have a key role in maintaining organismal homeostasis by scavenging blood-borne molecules and inducing specific immune tolerance to ingested antigens. The sca...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Case Report: Liver Metastasis from Ductal Carcinoma In Situ of the Breast
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Case Report: Liver Metastasis from Ductal Carcinoma In Situ of the Breast
Zhuang W et al · Dove Medical Press · 2026 · ISSN 1179-142X
Weiya Zhuang,1 Daozhe Lin,2 Chengliang Chen2 1Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Zhejiang, People’s Republic of China; 2Department of Thyroid an...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Cytotoxic effects of copper overload on human-derived lung and liver cells in culture
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Cytotoxic effects of copper overload on human-derived lung and liver cells in culture
Arnal, Nathalie et al · Elsevier Science · 2012 · ISSN 0304-4165
Background: Copper (Cu) is an essential trace metal used as a catalytic cofactor for many enzymes. However, it can have nocive effects when it participates in the Fenton reaction, producing reactive oxygen species (ROS)....
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