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Abstract Heart failure (HF) and chronic obstructive pulmonary disease (COPD) frequently co-occur, complicating treatment. Concerns about respiratory complications often lead to underuse of β-blockers in this population....

Objective: In contrast to penetrating trauma, blunt pancreatic trauma poses numerous challenges for treating surgeons, mainly due to the different clinical manifestations. Materials and methods: This is a retrospective o...

BackgroundItchy E3 ubiquitin ligase deficiency (ITCH deficiency) is a rare monogenic immune dysregulation syndrome characterized by early-onset multisystem autoimmunity and significant morbidity and mortality. Only one p...

Abstract Introduction Respiratory syncytial virus (RSV) is a major cause of morbidity and mortality among older adults. Limited information is available in Israel regarding RSV outcomes, particularly compared to influenz...

Introduction: The neonatal period is one of the most critical phases in an individual’s life. During this time, newborns undergo significant physiological changes as they adapt from the intrauterine to the extrauterine...

Abstract Background Chikungunya virus (CHIKV) infection can progress to severe clinical forms requiring intensive care. This study aimed to characterize adult patients admitted to intensive care units (ICUs) with CHIKV d...

Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)- associated pneumonia increases patients’ susceptibility to fungal superinfections, particularly among immunocompromised individuals. Cas...

Introduction: Ventilator Associated Pneumonia (VAP) is a common Healthcare Associated Infection (HAI) in mechanically ventilated patients, leading to increased morbidity, mortality, Intensive Care Unit (ICU) stays, and h...

BackgroundPatients with acute myeloid leukemia (AML) and prolonged neutropenia are at high risk for invasive fungal infections such as fusariosis, which represents the second most common pathogenic mold infection in this...

ObjectiveTo explore the effects of different serum potassium levels on the 28-day prognosis of elderly patients with sepsis. MethodsA retrospective analysis was conducted on the clinical data and laboratory indicators wi...

ObjectivePrevious randomized controlled trials have shown good efficacy and safety of omadacycline in patients with infectious diseases, but relevant real-world evidence is still insufficient. This large-scale study aime...

BackgroundX-linked hyper-IgM syndrome (XHIM) due to CD40L deficiency typically presents in early childhood with recurrent sinopulmonary or opportunistic infections, and its initial manifestations can be misleading. We re...

BackgroundEarly complement pathway deficiencies predispose to invasive infections with encapsulated bacteria. C2 deficiency is the most common human complement deficiency, yet it may remain clinically silent until a life...

We describe an outbreak of Klebsiella pneumoniae sequence type 11 (ST11) producing KPC variants resistant to ceftazidime-avibactam. Six patients hospitalized in the intensive care unit (mostly due to critical COVID pneum...

Wegener’s granulomatosis (WG) is a disorder that causes necrotizing granulomatosis vasculitis particularly of the upper respiratory tract, lung and kidney. A 43-year-old male who had been treated with hemodialysis beca...

Abstract Introduction We describe the burden of severe influenza in England overall, and in risk groups (as defined by age, immunocompromise, and other comorbidities) and those with recent COVID-19. Methods The INFORM (I...

"Background: The prevalence of reverse triggering (RT) in the early phase of ARDS is unknown. Research question: During early ARDS, what is the proportion of patients affected by RT, what are its potential predictors, ...

OBJETIVO: identificar os fatores obstétricos e neonatais associados ao desfecho de displasia broncopulmonar em pacientes com amniorrexe prematura no pré-termo. MÉTODOS: foram analisados 213 prontuários do Instituto F...

Abstract Fluid balance in the early stages of severe acute pancreatitis (SAP) significantly impacts patient outcomes. This study aimed to identify the optimal fluid balance value affecting adverse outcomes in SAP patient...

Abstract Objective Acute kidney disease (AKD) describes acute or subacute renal damage and/or loss of kidney function between 7 and 90 days after AKI initiation. Because there are few reports on AKD in older patients, t...

OBJECTIVE: Acute kidney injury (AKI) is a frequent complication of hospitalized patients that is associated with high mortality rate despite all developments. Continuous and intermittent hemodialysis are renal replacemen...

"To evaluate a novel physiological approach for setting the tidal volume in mechanical ventilation according to inspiratory capacity, and to determine if it results in an appropriate mechanical and gas exchange measurem...

Background and Literature ReviewHypereosinophilic syndrome (HES) is a rare, heterogeneous group of disorders defined by persistent hypereosinophilia (>1,500 cells/µL) with eosinophil-mediated end-organ damage. Its estim...

BackgroundDelirium and poor clinical prognoses are prevalent among ICU patients, particularly those requiring mechanical ventilation. While sedation is a cornerstone of intensive care, the impact of its depth remains con...