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Cadmium (Cd) accumulation in rice poses a serious threat to food safety. While soil amendments with manganese (Mn) and zinc (Zn) can reduce Cd accumulation in rice, their distinct modes of action remain unclear, hinderin...

Abstract Polygonati Rhizoma has been reported to exhibit the ability to retard skin aging. However, the precise molecular mechanisms underlying remain largely elusive. In this study, we screened 9 active compounds in Pol...

Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability worldwide. Endovascular mechanical thrombectomy (EVT) has revolutionized stroke treatment by enabling rapid recanalization of occl...

Benzo[a]pyrene (BaP), a widespread environmental pollutant, has been increasingly implicated in the pathogenesis of chronic degenerative diseases. Environmental pollutants have recently been recognized as emerging risk f...

Abstract Background Hepatocellular carcinoma (HCC) is a critical condition characterized by unchecked cellular growth in the liver, often leading to systemic inflammation and organ failure. Although its complex molecular...

Abstract Objective This study aimed to elucidate the molecular mechanisms by which Apigenin (APG) reverses MET-TKI resistance in non-small cell lung cancer (NSCLC). Methods Network pharmacology and molecular docking were...

Background: Barrett's esophagus (BE) represents a critical precancerous lesion arising from chronic gastroesophageal reflux disease (GERD), with significant risk of progression to esophageal adenocarcinoma. Despite advan...

ABSTRACT Carbapenem resistance mediated by blaNDM-encoded metallo-beta-lactamases is often linked to ISAba125, an insertion sequence from the IS30 family, which is widely distributed among critical and high-priority bact...

Smilax glabra, a perennial vine with high pharmaceutical value, exhibits seed dormancy under natural conditions that severely restricts artificial propagation and industrial-scale cultivation. This study aims to systemat...

Plant-parasitic nematodes (PPNs) are a serious threat to global food security, with estimated annual losses exceeding $173 billion. Beyond their direct damage, interactions between PPNs and other phytopathogens can lead ...

Abstract Industrialization and urbanization exacerbate global environmental health challenges, with pollutants from industrial and vehicular emissions (e.g., PAHs, NOx, PM2.5) posing significant risks. Growing evidence l...

Naringenin (NGN), a flavonoid widely utilized in agricultural and pharmaceutical applications, has increasingly become a source of environmental concern. This study systematically evaluated the developmental toxicity of ...

Background and aims Meat-borne Staphylococcus aureus (S. aureus) remains a leading global foodborne pathogen harbouring novel enterotoxin genes (NEGs) encoding superantigenic toxins with conditionally enhanced pathogenic...

Objective: To determine the optimal dosing ratio of the herbal components within compound Hemerocallis citrina Baroni (H. citrina) extract concentrate (CHEC), evaluate its antidepressant effects in zebrafish and mouse mo...

Spintronics based on ferromagnetic metals and organic semiconductors has attracted great interest in recent years. Molecular-based spintronic devices, such as magnetic tunnel junctions, have been demonstrated with perfor...

Kai Chen,1,* Yiqing Nong,1,* Ying Liu,2 Ziming Ye3 1Department of Neurology, Guangxi Medical University Kaiyuan Langdong Hospital, Nanning, 530023, People’s Republic of China; 2Department of Rehabilitat...

Abstract Esophageal cancer (EC) is a malignant tumor characterized by high incidence and mortality, and its complex pathogenesis necessitates the development of effective therapeutic strategies. In this study, we investi...

Since ischemic heart disease (IHD) is a major cause of mortality and heart failure, novel therapeutic strategies are expected to improve the clinical outcomes of patients with acute myocardial infarction. Brief episodes ...

Psychostimulant addiction is associated with dysfunctions in frontal cortex. Previous data demonstrated that repeated exposure to methamphetamine (METH) can alter prefrontal cortex (PFC)-dependent functions. Here, we sho...

Velvet antler, a valued traditional medicine of animal origin, contains an abundance of bioactive compounds including amino acids, peptides, proteins, and nucleosides. It exhibits notable health-promoting properties such...

The prevalence of age-related macular degeneration (AMD) has increased in the last years. Although anti-VEGF agents have improved the prognosis of exudative AMD, dry AMD has still devastating effects on elderly people vi...

Abstract The CRISPR‐Cas system constitutes an adaptive immune mechanism in prokaryotes that defends against mobile genetic elements. Within the perpetual co‐evolutionary arms race between bacteria and their viral pre...

Abstract Low testosterone in males (hypogonadism) is associated with limb muscle mass loss, yet the underlying mechanisms of muscle mass loss remain largely unknown. We previously showed androgen deprivation disrupted li...

Lysine lactylation (Kla) is a novel form of post-translational modification. It utilizes lactate as its core substrate. Through an enzymatic regulatory network, it mediates modifications of both histones and non-histone ...