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The prevalence of co-morbid gastrointestinal symptoms is high in dialysis patients, while abdominal pain, constipation, diarrhea, anorexia and abdominal bloating are the second-most common group of symptoms following dys...

Mansonella ozzardi (Nematoda: Onchocercidae) is an understudied filarial nematode, originally described by Patrick Manson in 1897, that can be transmitted by two families of dipteran vectors, biting midges (most of them ...

Background/Aim: Cysts which appear in the orofacial region are represented as common pathological changes which underlying mechanism of development is still not fully clear. In recent years, a dominant role in the pathog...

The global evolution of the SARS-CoV-2 virus is known to all. The diagnosis of SARS-CoV-2 pneumonia is expected to worsen, and mortality will be higher when combined with myocardial injury (MI). The combination of novel ...

Rosacea is a chronic inflammatory skin disorder primarily characterized by persistent facial erythema, episodic flushing, papules and pustules, as well as phymatous changes. Despite extensive research, the pathogenesis o...

Previous studies have suggested that macrophages may contribute to acute Leptospira dissemination, as well as having a major role in kidney fibrosis. Our aim was to characterize the role of macrophages and galectin 3 (Ga...

Abstract In recent years, with the continuous booming of diabetes patients, the research on diabetes and its complications, including pathogenesis, early diagnosis and therapeutic interventions, has attracted considerabl...

Background Depression in adolescents is recognised as a global public health concern, but little is known about the trajectory of its clinical symptoms and pathogenesis. Understanding the nature of adolescents with depre...

Abstract Mediterraneibacter gnavus is a human symbiotic gut bacterium whose abundance often increases in patients with various diseases, such as active inflammatory bowel disease (IBD). However, the genetic factors gover...

Abstract Background/Objectives Dilated cardiomyopathy (DCM) is characterized by heart failure and cardiac dilation, distinguishing it from ischemic and non-ischemic heart diseases. To date, more than 50 genes have been i...

Abstract Background Pancreatitis in cats, although commonly diagnosed, still presents many diagnostic and management challenges. Objective To summarize the current literature as it relates to etiology, pathogenesis, diag...

Protein aggregation plays a central role in the pathogenesis of many neurodegenerative diseases and poses major challenges in protein engineering. A key driver of this process is the presence of aggregation-prone regions...

Abstract Objective Epidemiological studies have shown evidence of the effect of genetic variations in the pathogenesis of breast cancer and have suggested a relationship of the disease with genetic polymorphisms. Matri...

Background: Emerging evidence has shown that exposure to polycyclic aromatic hydrocarbons (PAHs) is a risk factor for rheumatoid arthritis (RA). Benzo[a]pyrene (BaP), a representative PAH congener, exacerbates the develo...

Inflammation plays a key role in the pathogenesis of neurobrucellosis where glial cell interactions are at the root of this pathological condition. In this study, we present evidence indicating that soluble factors secre...

BackgroundTranscriptome−wide association study (TWAS) contributes to discovering novel susceptibility genes related to diseases. Single-cell RNA sequencing (scRNA-seq) has been extensively applied to characterize cellu...

Anti-glutamic acid decarboxylase (anti-GAD) autoimmunity possess a poorly understood diversity in the development of neurological manifestations with or without diabetes mellitus (DM) association. A possible genetic cont...

Uveitis is a group of diseases characterized by intraocular inflammation, closely associated with infectious, autoimmune, genetic, or environmental factors. Cell death, a critical biological process involved in developme...

BackgroundInfantile epileptic spasms syndrome (IESS) is a severe age-specific epileptic encephalopathy with unclear pathogenesis, and neuroinflammation is involved in its progression. The HMGB1-TLR4 signaling pathway, a ...

Objectives: To characterize the proliferative and immunophenotypic profiles of salivary gland mucoepidermoid carcinoma (MEC) and to explore their associations with clinicopathologic features, tumour microenvironment (TME...

O parto prematuro é a principal causa de morbidade e mortalidade neonatal. Cerca de 75% dos nascimentos prematuros são decorrentes do trabalho de parto espontâneo. A patogenia do parto prematuro espontâneo é complex...

Tripartite motif (TRIM)7 is an E3 ubiquitin ligase that was first identified through its interaction with glycogenin-1 (GN1), the autoglucosyltransferase that initiates glycogen biosynthesis. A growing body of evidence i...

Background: Copper (Cu) is an essential trace metal used as a catalytic cofactor for many enzymes. However, it can have nocive effects when it participates in the Fenton reaction, producing reactive oxygen species (ROS)....

Background: Osteoporosis has long been considered a disorder confined to bone tissue. Growing evidence now highlights its systemic origins, governed by intricate communication between multiple organs. The multi-organ-bon...