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Resumen: El cáncer de próstata (CaP) es uno de los tumores más frecuentes y una causa importante de mortalidad masculina. El uso rutinario del antígeno prostático específico (APE) ha permitido disminuir la mortalid...

Abstract Background Systemic thrombolysis is recommended for high-risk pulmonary embolism, but is associated with a substantial bleeding risk due to thrombolysis-induced coagulopathy. However, recent advances in precisio...

Artificial intelligence (AI) has emerged as a transformative force in modern ophthalmology, enabling rapid advances in disease detection, clinical decision support, workflow optimization, and tele-ophthalmology. Ophthalm...

Abstract X‐linked muscular dystrophy in cats (FXMD) is an uncommon disease, with few reports describing its pathogenic genetic variants. A 9‐year‐old castrated male domestic shorthair cat was presented with persist...

Polycystic ovary syndrome (PCOS) management mainly revolves around general lifestyle modifications that almost always include weight loss, an approach that fails to reflect the biological and ethnic diversity of the cond...

Resumen: La leucemia mieloide aguda es una neoplasia hematológica clonal y heterogénea, es la leucemia más frecuente en adultos, con una incidencia global cercana a 4 casos por 100 000 habitantes/año y un marcado inc...

Abstract Background Skeletal dysplasia encompasses a heterogeneous group of genetic disorders characterized by an abnormal development of bones, joints, and cartilage. Two Chianina half‐sibling calves from consanguineo...

Abstract Background Human patients with Ehlers‐Danlos syndrome (EDS) are categorized into subtypes based on causative genetic variants and phenotypes. The classical form of EDS, primarily caused by variants in COL5A1 o...

Background: This study developed and systematically optimized an ion-pair hydrophilic interaction liquid chromatography (IP-HILIC) system for oligonucleotide medicine analysis, aiming to the issues of insufficient resolu...

Abstract Background Mesenchymal stromal cells (MSCs) are widely used in regenerative medicine, but their clinical utility is limited by replicative senescence. Strategies that reverse aging while maintaining MSC identity...

Resumen: Las mutaciones germinales en genes de predisposición al cáncer han dejado de ser una información sólo asociada al riesgo de cáncer hereditario, en la actualidad se han convertido en un verdadero motor de ca...

Combined radiotherapy and chemotherapy remain central to cancer treatment, with metallodrugs – most notably platinum agents – playing indispensable roles in clinical regimens. However, systemic toxicity and limit...

The treatment paradigm for advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations is undergoing a significant transition. While third-generation tyrosine kinase inhibitors (TKIs) like osimertinib have long ...

Abstract Background Apoptosis is a fundamental biological process and a central determinant of therapeutic response in breast cancer (BC). Resistance to immunotherapy is increasingly recognized to be driven, in part, by ...

Pulmonary hypertension (PH) is a severe cardiopulmonary disorder characterized by pulmonary vascular remodeling, which leads to increased pulmonary vascular resistance (PVR), right ventricular (RV) hypertrophy, and ultim...

AimsUnderstanding atypical forms of diabetes (AD) may advance precision medicine, but methods to identify such patients are needed. We propose an electronic health record (EHR)-based algorithmic approach to identify pati...

Danhua Guo,1,2 Shuqiong He,1,2 Na Lin,1,2 Yifang Dai,1,2 Ying Li,1,2 Liangpu Xu,1– 3 Xiaoqing Wu1– 4 1Department of Medical Genetic Diagnosis and Therapy Center, Fujian Maternity and Child Health Hospital College of ...

Jiaxuan Wu,1– 5,* Huohuo Zhang,1– 5,* Lan Yang,1– 5,* Jiadi Gan,1– 5 Guoqing Wang,6 Xiaolong Tang,1– 5 Jinghong Xian,1– 5 Lin Zhu,7 Yalun Li,1– 5 Weimin Li1– 5 1Department of Pulmo...

Abstract Background Migraine is a very common chronic neurological disorder associated with severe disability and significant social burden worldwide. Beyond recurrent headache attacks, increasing evidence indicates that...

Abstract Background Continuous positive airway pressure (CPAP) remains the cornerstone of therapy for obstructive sleep apnea, yet its impact on preventing cardiovascular disease remains uncertain. Despite widespread cli...

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by aberrant immune responses and tissue remodeling. Ligustrazine has multiple effects, such as enh...

Abstract Background Proteins represent the dynamic downstream products of genes, and have the potential to substantially increase understanding of the complexities of cancer biology. Undifferentiated pleomorphic sarcoma ...

Type 2 diabetes (T2D) is a complex and multifaceted condition clinically characterized by high blood glucose. The management of T2D requires a holistic approach, typically involving a combination of pharmacological inter...