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Abstract Generative deep learning models have demonstrated significant potential in designing drug-like molecules. However, medicinal chemistry typically requires generating analogues that combine structural similarity w...

Background: The modern intrauterine contraceptive device (IUCD) is a highly effective, safe, private, long-acting, coitus-independent, and rapidly reversible method of contraception with few side methods of contraception...

Background: Cardiac complications arising from diabetes mellitus manifest as structural and functional myocardial alterations independent of traditional cardiovascular risk factors. The intricate molecular underpinnings ...

Brain death (BD), a non-immunological factor of renal injury, triggers an inflammatory process causing pathological signs of cell death in the kidney, such as necrosis and apoptosis. Kidneys from brain dead donors show l...

Abstract With the increasing performance requirements for data acquisition in applications such as the Internet of things and artificial intelligence, analog-to-digital converters (ADCs) face stringent trade-offs among s...

The scheduled and on-demand air services with Title 14 Code of Federal Regulations (CFR) Part 135 certificate are operating with relatively less stringent safety program criteria compared to Part 121 operations. The Part...

This study examines the Human Resources Governance (HRG) system in Tehran Municipality, focusing on its alignment with sustainable urban development. Tehran, Iran’s economic and political hub, faces unique HR challenge...

Morphology has had a great development within the scope of Computational Linguistics since it is the starting point to accomplish researches in other levels of representation. This time our focus of attention is on N (no...

Artificial intelligence (AI) is increasingly used to design and optimize small molecules. However, most current workflows remain centered on drug-candidate objectives, such as potency, ADMET, and drug-likeness, rather th...

Objective Endometriosis (EMs) is a chronic gynaecological condition characterised by the ectopic growth of endometrial tissue; however, its molecular mechanisms remain insufficiently understood. Ferroptosis, an iron-depe...

BackgroundCOVID-19 and mass incarceration are closely intertwined with prisons having COVID-19 case rates much higher than the general population. COVID-19 has highlighted the relationship between incarceration and healt...

Determining the quantum-classical boundary between quantum circuits that can be efficiently simulated classically and those that cannot remains a fundamental question. One approach to classical simulation is to represent...

A small-scale physical modelling system is developed to study the pull-out mechanism of embedded soil nails based on transparent soil and particle image velocimetry (PIV). Four types of soil anchorages, common cylindrica...

Immune checkpoint inhibitors (ICIs) have been game changer in cancer therapy but can trigger diverse immune-related adverse events (irAEs) that impact multiple organs. This review offers a unified perspective on irAE ris...

Context. Co-orbital objects, also known as Trojans, are celestial bodies that share a 1:1 mean motion resonance orbit with a planet. Many planets in our Solar System hold Trojans, yet none has been confirmed in exoplanet...

The formation of household savings is a key prerequisite for sustainable economic development and investment recovery in Ukraine. This article explores the role of credit unions as specific non-banking financial institut...

BackgroundResting metabolic rate (RMR) prediction equations used today often rely on the consideration of binary sex. Significant intrasex variability and a lack of data on diverse populations raise concerns about these ...

Cherenkov radiation in natural transparent materials is generally forward-propagating, owing to the positive group index of radiation modes. While negative-index metamaterials enable reversed Cherenkov radiation, the for...

Based on evidence that early antisocial behavior is a key risk factor for continued delinquency and crime throughout the life course, early family/parent training, among its many functions, has been advanced as an import...

Abstract Background High‐income countries offer social assistance (welfare) programs to help alleviate poverty for people with little or no income. These programs have become increasingly conditional and stringent in r...

Abstract Infectious disease diagnostics has been transformed by metagenomic next‐generation sequencing (mNGS), an unbiased approach that detects bacteria, viruses, fungi, and parasites in a single assay. By sequencing ...

Abstract Land subsidence induced by underground coal mining consistently leads to persistent ponding in coal-grain overlapping areas (COAs), substantially impairing agricultural productivity. However, amid stringent farm...

Generalized dualities had an intriguing incursion into Double Field Theory (DFT) in terms of local O(d, d) transformations. We review this idea and use the higher derivative formulation of DFT to compute the first order ...

We study the phase structure of the Witten-Sakai-Sugimoto model in the plane of temperature and baryon chemical potential, including the effect of a nonzero current quark mass. Our study is performed in the decompactifie...