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Background: Distal femoral megaprosthetic reconstruction is a standard limb-salvage procedure after tumor resection. This study aimed to evaluate implant survival and associated factors, the incidence of mechanical failu...

Abstract Background Sorafenib has served as standard treatment for advanced hepatocellular carcinoma (HCC). Recently, several randomized controlled trials (RCTs) have explored the use of programmed cell death protein 1/p...

BackgroundProstate cancer is the sixth most common cause of cancer-related death in males globally and is often identified as a secondary malignancy. Early detection and appropriate management increase the patient’s li...

Abstract Objective To investigate the clinicopathological significance and prognosis of the expression of the anterior gradient 3 (AGR3) protein in women with breast cancer. Data Sources The PubMed, CINAHL, EMBASE, Sco...

BackgroundPrimary malignant bone tumors are aggressive neoplasms that frequently affect adolescents and young adults. Limb-sparing surgery (LSS) has become the preferred surgical approach when oncologically feasible; how...

Abstract Background Programmed death-ligand 1 (PD-L1) is widely used as a predictive biomarker for response to immune checkpoint inhibitors in gastric cancer (GC); however, its independent prognostic value for overall su...

IntroductionHepatocellular carcinoma (HCC) is a lethal malignancy, with hepatitis B virus (HBV) infection as its leading cause in China. Transarterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) ...

This study is performed in Istanbul University Cerrahpaşa Medical Faculty Haemodialysis Unit. 172 patients (mean age 45 years; 109 males, 63 females) regularly dialysed for at least longer than 3 months in our unit betw...

Background: Neoadjuvant chemoradiation therapy (nCRT) has survival benefits for patients with cT1N1 or cT2–3N0-1 esophageal squamous cell carcinoma (ESCC), but heterogeneous disease behavior has been observed in node...

Abstract Background Lung stereotactic body radiotherapy (SBRT) is the standard of care for patients with inoperable early-stage non-small cell lung cancer (NSCLC), who frequently have significant comorbidities. There is ...

Abstract Background Lymphoma has been implicated as a possible cause of proteinuria in dogs. However, information about the potential importance of proteinuria in dogs with lymphoma is limited. Hypothesis To determine if...

Abstract Background Primary pulmonary lymphoepithelial carcinoma (PPLEC) is an extremely rare subtype of lung squamous cell carcinoma (LUSC). This study aims to comprehensively characterize clinicopathological and molecu...

Abstract Objective To investigate the influence of postoperative pathological factors (including variables not categorized as moderate - to - high - risk factors according to the Sedlis criteria) on the prognosis and lym...

One of the key elements related to calculating Customer Lifetime Value is to estimate the duration of a client’s relationship with a bank in the future. This can be done using survival analysis. The aim of the article ...

Abstract Background Outcomes after curative-intent sarcoma surgery vary substantially and are incompletely explained by tumor-centered factors alone. Although CT-based body composition metrics provide objective host-rela...

Introduction Childhood cancer survival rates are not equal for all, with disparities existing both between and within low- and middle-income countries and high-income countries, particularly among ethnic minorities and c...

ABSTRACT Background The comparative effectiveness of radiotherapy and surgery for treating intracranial meningioma is unknown. Objectives To compare survival after treatment of suspected intracranial meningioma by either...

Background: Previous studies have demonstrated that thoracic radiotherapy (TRT) following first-line chemoimmunotherapy improves survival in extensive-stage small cell lung cancer (ES-SCLC). However, its efficacy and saf...

Background Urine protein loss is common in dogs with chronic kidney disease (CKD). Hypothesis/Objectives To evaluate new biomarkers of glomerular and tubulointerstitial (TI) damage compared with histology and as survival...

Abstract Background Colorectal signet ring cell carcinoma (CSRCC) is a rare subtype of colorectal cancer characterized by an exceptionally poor prognosis. Currently, accurate survival prediction models for CSRCC are lack...

Abstract Background Traumatic brain injury (TBI) needs inter-disciplinary care through pre-hospital resuscitation, emergency and neurosurgical care, neurocritical care, and structured neurorehabilitation to maximize surv...

BackgroundHydrops fetalis encompasses diverse fetal disorders with high perinatal mortality, and contemporary regional data are limited.MethodsWe conducted a single-center retrospective cohort study at a Saudi tertiary r...

Abstract Background While diabetes mellitus (DM) has been reported as a risk factor for development and prognosis of pancreatic ductal adenocarcinoma (PDAC), the specific impact of glycemic control on clinical outcomes r...

Background Subaortic stenosis (SAS) is one of the most common congenital cardiac defects in dogs. Severe SAS frequently is treated with a beta adrenergic receptor blocker (beta blocker), but this approach largely is empi...