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Epilepsy is a common neurological disorder which affects 50 million people worldwide. Patients with epilepsy may present cognitive deficits and psychological impairment. Currently, 30% of patients fail to respond to any ...

Abstract Epilepsy, characterized by abnormal neuronal hyperexcitability and disrupted ion homeostasis, increasingly appears to involve complex neuron–glia interactions. This study develops a three-compartment computati...

Epilepsy is a debilitating neurological disorder characterized by recurrent seizures, affecting millions of patients worldwide. Retrospective studies in temporal lobe epilepsy (TLE) patients have shown a high incidence o...

Asparagine-linked glycosylation 13 homolog (ALG13) encodes a nonredundant, highly conserved, X-linked uridine diphosphate (UDP)-N-acetylglucosaminyltransferase required for the synthesis of lipid linked oligosaccharide p...

Abstract Background Neurofilament light chain (NfL) is released into the peripheral circulation by damaged axons. Objectives To evaluate the diagnostic value of serum NfL concentration in dogs with intracranial diseases....

Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of ex...

Este depoimento representa mais uma lição de vida que um estudo teórico. Os três anos de trabalho voluntário na Associação dos Portadores de Epilepsia de Minas Gerais me permitiram conhecer e assistir a alguns por...

Abstract Purpose MELD Graph is a state-of-the-art artificial intelligence (AI) model for automated detection of focal cortical dysplasia (FCD), but its performance remains limited, highlighting the need to investigate wh...

A 22 year-old-male was admitted with macroscopic hematuria. He had a diagnosis of tuberous sclerosis complex (TSC). On physical examination, angiofibromas were observed in the nasolabial folds and hypomelanotic macules w...

Background Antiseizure medications (ASMs) are the standard treatment for epilepsy. Yet because ASMs can have adverse effects and seizure risk decreases with longer seizure-free periods, guidelines have suggested consider...

Abstract Background Weyers acrofacial dysostosis (WAD) is a rare autosomal dominant ciliopathy caused by heterozygous pathogenic variants in the EVC2 gene. The classic phenotype includes short stature, dental anomalies, ...

Abstract Epilepsy is a chronic neurological disease that profoundly impacts patients’ daily lives. Electroencephalography (EEG) serves as a crucial tool for the clinical diagnosis of epilepsy and other brain disorders....

Las crisis atónicas focales son poco reconocidas como fenómenos ictales, pueden corresponder tanto a una epilepsia generalizada como a una epilepsia focal. Las áreas del cerebro implicadas en la gestión de este tipo ...

BackgroundInfantile epileptic spasms syndrome (IESS) is a severe age-specific epileptic encephalopathy with unclear pathogenesis, and neuroinflammation is involved in its progression. The HMGB1-TLR4 signaling pathway, a ...

Purpose: Previous studies from a few countries have reported semiological differences in younger children compared with adolescents or adults with psychogenic nonepileptic seizures (PNESs). This study tested the hypothes...

Introduction: Febrile Seizures (FS) are common in early childhood, and bedside biochemical testing is frequently ordered despite mixed evidence regarding underlying biochemical drivers. Clarifying which analytes truly di...

Abstract Choosing to approach or avoid is common in everyday life and excessive avoidance is a cardinal feature of anxiety disorders. We use intracranial EEG to define a prefrontal-limbic circuit supporting approach and ...

Abstract Objective To accurately predict neurological outcomes among survivors after cardiac arrest (CA), we aim to analyze the experimental data of epileptiform electroencephalography (EEG) in CA survivors to explore th...

Lissencephaly type 10 (LIS10, OMIM#618873) is a rare neurodevelopmental disorder characterized by posterior-predominant pachygyria/agyria or subcortical band heterotopia on brain imaging. Clinically, affected individuals...

Abstract Background Migraine is a very common chronic neurological disorder associated with severe disability and significant social burden worldwide. Beyond recurrent headache attacks, increasing evidence indicates that...

Abstract A 5‐and‐a‐half‐year old, 9‐kg, spayed, female Welsh Terrier presented with a 12 month history of paroxysmal exertion‐induced dyskinesia (PED) characterized by recurrent episodes of involuntary hype...

Pothos scandens, belonging to the Araceae family, locally known as “batilata,” is traditionally used for treating various chronic diseases in folk medicine, such as epilepsy, seizures, convulsions, wounds, snakebites...

Abstract Periventricular nodular heterotopia is a common neuronal malformation in humans, often leading to epilepsy and other neurologic diseases. A 2‐month‐old female Chihuahua weighing 750 g was examined because ...