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We present Model-based Analysis of ChIP-Seq data, MACS, which analyzes data generated by short read sequencers such as Solexa's Genome Analyzer. MACS empirically models the shift size of ChIP-Seq tags, and uses it to imp...

TopHat is a popular spliced aligner for RNA-sequence (RNA-seq) experiments. In this paper, we describe TopHat2, which incorporates many significant enhancements to TopHat. TopHat2 can align reads of various lengths produ...

Bowtie is an ultrafast, memory-efficient alignment program for aligning short DNA sequence reads to large genomes. For the human genome, Burrows-Wheeler indexing allows Bowtie to align more than 25 million reads per CPU ...

Materias / palabras clave: bacterial genomics and evolution, comparative bacterial genomics, population genomics in bacteria, bacterial development, bacterial adoption, barterial physiology; Medicine: Internal medicine: Specialties of internal med...

Materias / palabras clave: genome and sequence analysis, gene and protein expression, genetics and population analysis, comparative genomics, computational functional genomics, protein dynamics and function; Medicine: Internal medicine: Neuroscien...

Materias / palabras clave: genomic medicine, medical genetics, genomics, laboratory genetics and genomics, clinical genomics, therapeutics; Science: Biology (General): Genetics; Medicine

Materias / palabras clave: gene discovery, population genetics, genome projects, comparative genomics, functional genomics, medical genetics; Science: Biology (General): Genetics