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Abstract Background Triple-negative breast cancer (TNBC) is a subtype of breast cancer which has the poorest prognosis, with high recurrence and metastasis rates. ZNF503 (Zinc finger elbow-related proline domain protein ...

Abstract Inducing protein oligomerization holds therapeutic promise, yet identifying or rationally designing effective inducers remains challenging. In this study, we leverage nanopore technology to screen small molecule...

Objective: To develop an antimicrobial and anti-adherent thymol (TOH)-containing coating on titanium (Ti) by a bioinspired one-step biocompatible method. Methods: A nanolayer of adsorbed TOH (TOH-NL-Ti) was formed by an ...

Abstract Background Epithelial ovarian cancer (EOC) is a highly heterogeneous malignancy with significant morbidity and mortality, and cisplatin (DDP) resistance remains a major obstacle in its treatment. Previous studie...

Abstract Oxidative stress and impaired glucose metabolism are central to the development of chronic diseases such as diabetes mellitus. Medicinal plants provide valuable sources of bioactive compounds with antioxidant an...

Drug discovery research faces significant challenges, with around 90 % of candidate drugs failing in clinical trials. Traditional animal models do not always accurately reflect human physiology and pathology, leading to ...

BackgroundForkhead box N1 (FOXN1) is the master transcriptional regulator of thymic epithelial cells (TECs), quintessential for T cell development. Well-defined biallelic FOXN1 loss-of-function variants lead to congenita...

Thymic stromal cells drive T cell development by supplying key cues for progenitor proliferation and differentiation. Although thymic epithelial cells are well characterized, recent studies highlight crucial functions of...

Abstract Cardiac tissue from autoimmune myocarditis mice was studied to evaluate the expression and biological activity of mRNA encoding H(1) receptor and iNOS. BALB/c inbred mice were immunized with heart protein and s...

Abstract Background Despite limited evidence of efficacy, antibiotic treatment is still frequently prescribed in dogs with uncomplicated acute diarrhea (AD). Objective To assess whether amoxicillin‐clavulanic acid has ...

We report the emergency development and application of a robust serologic test to evaluate acute and convalescent antibody responses to SARS-CoV-2 in Argentina. The assays, COVIDAR IgG and IgM, which were produced and pr...

Abstract In this study, a method for expressing Cryptosporidium hominis GP60 glycoprotein in Escherichia coli for production of polyclonal anti-GP60 IgY in chickens was developed aiming future studies concerning the diag...

Abstract The objective of this study was to evaluate the composition, pH, titratable activity, microbial properties, and antioxidant effect of yogurt using ginseng extract powder (GEP), Lactobacillus plantarum NK181, and...

Research on lactobacilli from traditional food niches have received increasing attention for theirbeneficial properties. In this study, selected bacteriocin-producing lactobacilli strains previouslyisolated and character...

OBJECTIVE: To evaluate fatty acid plasma levels, phospholipase A2 activity, and the developmental profiles of children with autism vs. control subjects. METHODS: Twenty four children with autism underwent laboratory anal...

Abstract Background Laccases (LACs) are multicopper oxidases that play vital roles in lignin polymerization, cell wall formation, and various stress responses in plants. Despite their importance, genome-wide investigatio...

Plants frequently encounter diverse abiotic stresses, which require precise transcriptional regulation to maintain basic survival plasticity. The BES1 transcription factor family, a key component of brassinosteroid (BR) ...

IntroductionNeutrophils, the most abundant leukocyte population, play a central role in host defense against group B Streptococcus (GBS), an encapsulated bacterium that frequently causes severe infections in humans, incl...

Abstract Autophagy plays an important role in maintaining cell homeostasis through degradation of denatured proteins and other biological macromolecules. In recent years, many researchers focus on mechanism of autophagy ...

Abstract Background Gastrointestinal stromal tumors (GISTs) are primarily treated with tyrosine kinase inhibitors (TKIs) such as imatinib. However, the development of drug resistance remains a critical clinical challenge...

Abstract Objective Thyroid-stimulating hormone beta subunit (TSHB) gene, a member of the glycoprotein hormone beta subunit family, has been detected in ovarian tissues and granulosa cells (GCs) of several species, sugges...

Abstract Background In East Africa, bovine schistosomiasis, although common, is poorly appreciated and managed, detrimentally impacting upon livestock health. In certain settings, bovine schistosomiasis may be involved i...

Abstract Esophageal cancer (EC) is a malignant tumor characterized by high incidence and mortality, and its complex pathogenesis necessitates the development of effective therapeutic strategies. In this study, we investi...

Abstract Postbiotics are defined as probiotics inactivated by heat, ultraviolet radiation, sonication, and other physical or chemical stresses. Postbiotics are more stable than probiotics, and these properties are advant...