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The clinical management of autoimmune liver diseases is frequently complicated by the concomitant presentation of hepatitic and cholestatic features, an entity clinically designated as Overlap Syndrome. While the majorit...

Early recognition and prompt specific treatment are crucial factors influencing the outcome of pa- tients with acute encephalitis. The aim of this study was to determine the main causes of acute encephalitis in our popul...

ABSTRACT Eosinophilic enteritis is a cause of recurrent colic and progressive weight loss, characterized by an infiltrate of inflammatory cells-primarily eosinophils-in the intestinal mucosa. The etiology is related to i...

HELIOS is an IKAROS-family zinc-finger transcription factor that plays an important role in regulatory T cell function and conventional T cell homoeostasis. HELIOS shares a conserved N-terminal DNA-binding and C-terminal...

Serum sickness is an immune complex-mediated hypersensitivity reaction, classically manifested by the triad of fever, rash, and arthralgias. It results from the formation and deposition of antigen–antibody complexes, l...

ABSTRACT: Introduction and aims: To provide the research progress on the cGAS-STING signalling pathway and its related roles in various oral diseases. Methods: We reviewed the recent research on cGAS-STING in PubMed. Th...

Context: Signal transducer and activator of transcription 5b (STAT5b) deficiency, first reported in a patient who carried a p.Ala630Pro missense mutation in the Src homology 2 (SH2) domain, results in a rare clinical con...

Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune central nervous system disorder mainly associated with aquaporin-4 antibodies. While it primarily affects the optic nerves and spinal co...

Abstract Immune system dysregulation is implicated in a wide range of human diseases, including cancer. Genetic studies have shown evidence of a link between immune diseases and cancer; therefore, deficits of immune syst...

Abstract There is a growing body of research on disease clusters in multimorbidity. Here we systematically review clustering methodologies and perform a meta-analysis of disease cluster stability across the literature, s...

SASH3 deficiency is an X-linked combined immunodeficiency characterized by recurrent sinopulmonary, cutaneous, and mucosal infections, refractory autoimmune cytopenia, and immune dysregulation. We report here the first t...

Background:Celiac disease is a genetic autoimmune disorder; children with celiac disease may have malabsorption, electrolytes and acid-base disturbance. Electrolytes like ( Sodium, Potassium, and Chloride) have an essent...

Background and aimsLiver sinusoidal endothelial cells (LSECs) have a key role in maintaining organismal homeostasis by scavenging blood-borne molecules and inducing specific immune tolerance to ingested antigens. The sca...

Reflectance confocal microscopy is a non-invasive diagnostic method that enables real-time visualization of tissues in near-histological resolution. Pemphigus is a chronic autoimmune skin disease in which intra-epidermal...

Anti-glutamic acid decarboxylase (anti-GAD) autoimmunity possess a poorly understood diversity in the development of neurological manifestations with or without diabetes mellitus (DM) association. A possible genetic cont...

Background22q11.2 deletion syndrome (DS) is the second most common cause of congenital heart disease (CHD) and a multisystem disorder that contributes to substantial overall disease burden. Additionally, 22q11.2DS is the...

Severe gingival inflammation, which is uncommon in pediatric patients, often indicates underlying systemic conditions. Leukemia, autoimmune diseases, and allergic symptoms can cause gingivitis owing to systemic inflammat...

Abstract Brain pericytes are mediators of neuroinflammation, as evidenced in vitro, in animal models and humans. We and others have identified the platelet-derived growth factor (PDGF)-BB -PDGF receptor beta (PDGFRB) pat...

Abstract Myasthenia, a syndrome of impaired neuromuscular transmission, occurs as either an acquired or congenital condition. Myasthenia gravis (MG) is an acquired autoimmune disorder with autoantibodies against the neur...

BackgroundCommon variable immunodeficiency (CVID) is a primary immunodeficiency marked by impaired antibody production and infection susceptibility, with about half developing noninfectious complications. B cell activati...

Introduction. Alopecia areata (AA) is a chronic inflammatory disease that involves hair follicles, and sometimes nails, caused by a T-cell mediated autoimmune mechanism. Current treatment modalities include corticostero...

Atopic dermatitis (AD) and narcolepsy type 1 (NT1) are two distinct diseases that have not been classically shown to be related. The potential connection between the known immunological aetiology of AD and the proposed a...

Interferon regulatory factor-2-binding protein-2 (IRF2BP2) is a transcriptional regulator affecting diverse cellular functions, including cell differentiation and apoptosis. It plays an important role in lymphocyte and m...

Abstract Background Sjögren’s disease is a systemic autoimmune disease characterized by dysfunction of the salivary and lacrimal glands, leading to xerostomia and xerophthalmia. Case presentation A 55-year-old Hispani...