Buscar recursos académicos

B cell-mediated immunity plays a crucial role in long-term humoral protection. However, dysregulation of B cell development and differentiation may lead to the persistence of autoreactive clones, contributing to autoimmu...

The low-carbohydrate ketogenic diet (LCKD), developed a century ago to treat epilepsy, is now commonly used as a therapeutic intervention for obesity, type 2 diabetes and other conditions associated with insulin resistan...

BackgroundDown syndrome (DS) is associated with chronic hyperactivation of interferon signaling and downstream Janus kinase (JAK) and STAT pathways, contributing to increased susceptibility to autoimmunity, autoinflammat...

Context The very early diagnosis of systemic sclerosis (VEDOSS) criteria were developed to diagnose systemic sclerosis (SSc) at a very early stage. However, several studies have applied these criteria inconsistently, oft...

IntroductionRelA deficiency is a recently recognized inborn error of immunity (IEI) caused by mutations in the RELA gene. RelA is a transcriptional factor in the NF-kB pathway. Deficiency of RelA leads to impaired downre...

Abstract Background Neutrophils (polymorphonuclear leukocytes, PMNs) have long been underestimated in the context of autoimmunity. To elucidate their role from a sex-specific perspective, an immunoendocrinological framew...

STAT1 gain-of-function (GoF) is an inborn error of immunity characterized by a common feature of chronic mucocutaneous candidiasis and variable additional clinical manifestations, including recurrent bacterial and viral ...

BackgroundThymoma, a neoplasm of the thymus, leads to hypogammaglobulinemia in ∼10% of affected patients, resulting in Good syndrome that frequently coexists with autoimmunity and mucosal candidiasis. Thymomas lose the...

Zinc is a key micronutrient of the skin, where it is responsible, among others, for regulating the processes of melanocyte proliferation, maturation, and differentiation. Recent research has revealed a possible link betw...

C1q deficiency is an inheritable immune disorder attributed to biallelic pathogenic mutations in C1q genes (C1QA, C1QB, or C1QC). Patients with C1q deficiency demonstrate increased susceptibility to severe infections and...

The interplay between thyroid hormone action and the immune system has been established in physiological and pathological settings. However, their connection is complex and still not completely understood. The thyroid ho...

Primary Immunodeficiencies (PI) include more than 550 monogenic disorders presenting with recurrent infections, autoimmunity, and significant morbidity. Early molecular diagnosis is essential for guiding targeted treatme...

BackgroundRegulator of telomere elongation helicase 1 (RTEL1) is a gene that encodes a DNA helicase crucial for DNA repair and telomere maintenance. It belongs to a family of genes associated with telomere biology disord...

IntroductionBACH2-related immunodeficiency and autoimmunity (BRIDA) increases the risk of developing B cell lymphoma. We present a case of a patient with a known history of common variable immunodeficiency (CVID) and BAC...

BackgroundCOPA syndrome is a rare autosomal-dominant immune dysregulation disorder caused by pathogenic variants in the COPA gene, typically presenting with autoimmunity, arthritis, and interstitial lung disease. However...

Autoimmune encephalitis are one of the emergent causes of subacute changes in the level of consciousness, behavior, cognitive impairment and seizures, mainly in young people. They are a consequence of inflammation or dys...

Materias / palabras clave: Biology; Innate immune system; Pattern recognition receptor; Immune system; Immune receptor; Autoimmunity; Receptor; Immunity; Immunology; Innate lymphoid cell; Acquired immune system; Pathogen-associated molecular patte...

Materias / palabras clave: Biology; Receptor; Pattern recognition receptor; Inflammation; Signal transduction; Cell biology; Immunology; Innate immune system; Autoimmunity; Nod; C-type lectin; Damp

Materias / palabras clave: human immunology, human diseases, immunotherapy, autoimmunity; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Materias / palabras clave: autoimmunity, hypersensitivity, allergy, tumor immunology, immunodeficiencies, vaccine; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Materias / palabras clave: immunology, vaccines, tumor immunology, microbial immunity, allergy and autoimmunity, immunogenetics; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Materias / palabras clave: autoimmunity, immunology, immunogenetics; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Materias / palabras clave: immunology, allergy, autoimmunity; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Materias / palabras clave: innate immunity and inflammation, structural immunology, autoimmunity and immunoregulation, neuroimmunology, immunopathology and immunohistology, clinical/translational immunology; Medicine