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Next generation risk assessment (NGRA) demands a fundamental transformation in how toxicological test methods are validated. Traditional validation approaches, designed for animal tests and mainly for simple in vitro met...

Early porcine embryos undergo rapid growth and extensive physiological remodeling during the peri-implantation period. Despite the importance of this developmental window for establishment of pregnancy, the degree of bio...

Abstract Background Anti-amyloid monoclonal antibodies are entering clinical practice for early symptomatic Alzheimer’s disease (AD), but European real-world data on feasibility, safety, and biomarker monitoring remain...

Abstract Over the past decades, advances in technique have turned radiotherapy into a precise and effective modality for cancer treatment. Nevertheless, the biological effect on organs surrounding the tumor target area i...

Humans utilise about 40% of the earth’s net primary production (NPP) but the products of this NPP are often managed by different sectors, with timber and forest products managed by the forestry sector and food and fibr...

Abstract To interpret and transmit biological signals, proteins use correlated motions. Experimental determination of these dynamics and the structural distributions they generate remains a key challenge. Here, using 114...

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disease characterized by heterogeneous symptom patterns. Previous work suggested that specific symptoms tend t...

Background: The release of micro- and nanoplastics (MNPs) from tea bags during brewing is a significant, recently identified source of potential human exposure. This systematic review collected global research published ...

Abstract Background The risk of outbreaks escalating into pandemics has soared with globalization. Therefore, understanding transmission mechanisms of infectious diseases has become critical to formulating global public ...

Abstract Ecological momentary assessment (EMA) is a tool facilitating the repeated collection of real-time data in naturalistic settings that can be applied to clinical research. Despite established methodological streng...

ObjectiveThis study aims to investigate the correlation between trace element concentrations, 25-hydroxyvitamin D [25(OH)D] levels, and the severity of tic disorders (TD) in children from the Hubei region. Additionally, ...

Introductions: Mental retardation can be defined as a significant and direct lack of overall intellectual functioning that causes social maladaptation, a condition due to below-average intelligence. The lack of intellect...

Abstract Background Decompressive craniectomy (DC) is a life-saving measure in severe traumatic brain injury (TBI), but its long-term functional outcome and the time of subsequent cranioplasty remain debated. Recent evid...

Introduction: Patients with tuberculosis often struggle not only with the burden of physical illness but also significant psychological challenges, especially depression, that affect their quality of life profoundly. Met...

Abstract Background Moving to a new country for work can be incredibly stressful, especially for physicians who already face high-pressure jobs. This study explores symptoms of depression and anxiety, along with self-rep...

Abstract Background Plasma glial fibrillary acidic protein (GFAP) has emerged as a promising biomarker of astrocytic reactivity in preclinical Alzheimer´s Disease (AD). However, most evidence to date comes from ultrasen...

Abstract Background The literature on the age variability and its effect on clinical outcome of patients undergoing awake craniotomy (AC) procedure is lacking. We aimed to compare the varied age groups as defined by the ...

Abstract The proposed empirical research investigated the impact of emotional maturity on job satisfaction among healthcare employees. The study further examined the mediating and moderating roles of emotional intelligen...

BackgroundIdentifying factors predictive of relapse in patients with alcohol use disorder (AUD) following a period of abstinence and/or treatment is essential to discover effective treatment plans for this disease. Previ...

Abstract Background Suprasellar meningiomas are classically removed through several different surgical transcranial approaches, including the pterional transsylvian route. Recently, the indications for the transsphenoida...

Abstract Background Children with Unilateral Cerebral Palsy (UCP) are characterized by significant upper limbs (ULs) impairment that hinders daily activities and participation, requiring accurate assessment. Although mot...

Abstract Background Traumatic brain injury (TBI) needs inter-disciplinary care through pre-hospital resuscitation, emergency and neurosurgical care, neurocritical care, and structured neurorehabilitation to maximize surv...

Abstract Introduction Palestinian political prisoners are subjected to systematic torture, sensory deprivation, and psychological violence in Israeli prisons. The effects of incarceration continue after release, shaping ...

BackgroundBuilt environments shape navigation, attention, and motor control through continuous brain–body-environment coupling, yet architecture, rehabilitation, and clinical mobility practice still lack a shared quant...