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Primary human intestinal epithelial cells (IECs) require microenvironments that reproduce various in vivo cues to maintain survival, differentiation, and function in vitro. In this study, we investigated how intestinal s...

Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive. Using two different strategies t...

Background/Aims: Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal malignancy characterized by high invasiveness. The current study aimed to evaluate the role of miR-3678-3p in ESCC and its potential mechan...

Identification of specific genetic markers that determine interbreed differences and “selection signatures” in commercial pig breeds will allow for the development of more effective strategies for targeted breeding a...

Abstract Cell differentiation is a complex process characterized by specific gene expression patterns regulated through enhancer-promoter interactions within the three-dimensional architecture of the nucleus. The precise...

IntroductionBACH2-related immunodeficiency and autoimmunity (BRIDA) increases the risk of developing B cell lymphoma. We present a case of a patient with a known history of common variable immunodeficiency (CVID) and BAC...

Stem cell therapy, a highly recognized approach in the field of regenerative medicine, is known for its potential to stimulate the self-healing process of the body using stem cells or their derivatives, in which urine-de...

Immunophilins are a family of proteins whose signature domain is the peptidylprolylisomerase domain. High molecular weight immunophilins are characterized by the additional presence of tetratricopeptide-repeats (TPR) thr...

It is known that bradykinin (BK) B2 receptor (B2R) is expressed in the collecting duct (CD) cells of the newborn rat kidney, but little is known about its role during early postnatal life. Therefore, we hypothesize that ...

Early recognition and prompt specific treatment are crucial factors influencing the outcome of pa- tients with acute encephalitis. The aim of this study was to determine the main causes of acute encephalitis in our popul...

With the purpose of shedding light on some doubts in veterinary oncology, the present article intends to compare the results of histopathological and immunohistochemical examinations of unspecific round cell neoplasia, t...

Aberrant DNA methylation observed in cancer can provide survival benefits to cells by silencing genes essential for anti-tumor activity. DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherw...

Thymic stromal cells drive T cell development by supplying key cues for progenitor proliferation and differentiation. Although thymic epithelial cells are well characterized, recent studies highlight crucial functions of...

Abstract Background The tumor microenvironment of oropharyngeal squamous cell carcinoma (OPSCC) harbors diverse immune cell populations that influence tumor progression and patient outcome. Materials In 102 surgically tr...

Clinical trials of adoptive cellular therapy demonstrate that a key characteristic associated with durable responses is in vivo expansion and persistence of transferred T cells. Strategies to develop a less differentiate...

Galectin-3 (Gal-3) is a β-galactoside-binding lectin that plays an important role in inflammatory and neurodegenerative diseases. Cuprizone (CPZ)-induced demyelination is characterized by the loss of mature oligodendroc...

Tissue resident memory CD4+ T cells (TRMs) populate mucosal sites and play a critical role in local immune responses. Gut TRM cells persist for extended periods in the gut mucosa where they rapidly respond to invading pa...

Background: In multiple sclerosis (MS), chronic “smoldering” lesions are driven by microglial activation, which promotes demyelination and disease progression. However, microglia exhibit a functional dichotomy by per...

Lipopolysaccharide (LPS) triggers signal transduction in dental pulp cells (DPCs), leading to various biological events. The present study described the biological response of DPCs to LPS, aiming to provide a deeper unde...

Abstract Despite advances in therapy, survival rates for metastatic melanoma remain low. Drug-tolerant persister cells (persisters) can facilitate cancer recurrence, yet their characteristics and vulnerabilities differ a...

BackgroundGlucose-6-phosphate dehydrogenase (G6PD) provides the main cellular source of NADPH through the pentose phosphate pathway, supporting antioxidant defenses and metabolic programs required for hematopoietic devel...

Abstract Background Several cyanobacterial strains are known to contain a high number of genome copies and elevated cell cycle dynamics. We systematically investigated the ploidy of the model cyanobacterium Synechocystis...

STAT3 signaling is fundamental to T cells, where it underlies basic cellular processes like metabolism and apoptosis, as well as specialized processes like effector differentiation and cytokine production. However, mutat...

Abstract Recent advancements in single-cell DNA methylation (scDNAm) sequencing technologies have enabled the profiling of epigenetic landscapes at unprecedented resolution, offering insights into cellular heterogeneity,...