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Previously we established a family of macrocyclic peptide triazoles (cPTs) that inactivate the Env protein complex of HIV-1, and identified the pharmacophore that engages Env’s receptor binding pocket. Here, we examine...

Abstract Liver cirrhosis represents a progressive vascular and metabolic disease, which results due to chronic inflammatory injury to the tissues and presents with aberrant tissue regeneration, fibrosis with nodular conf...

Kexin Ma, Jinqiao Tian, Hao Wu, Shuzheng Wang, Hao-Sheng Ni Department of Otolaryngology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, People’s Republic of ChinaCor...

Abstract Background and objectives Squamous cell carcinoma antigen recognized by T-cells 3 (SART3) has emerged as a promising target for cancer immunotherapy, given its overexpression in various malignancies and low or a...

We recently identified Galectin-1 (Gal-1), a β-galactoside-binding lectin, as a novel immune regulator in neuroblastoma (NB). Here, we characterized the tolerogenic function of Gal-1 within the CD8+ T cell compartment a...

Airborne particulate matter 10 (PM10) induces lung inflammation. However, interventions remain limited. We evaluated the protective effects of Chrysanthemum zawadskii var. latilobum (CZL) against PM10-induced lung injury...

Aging associated with cellular senescence was responsible for the degradation of collagen and elastin by activation of matrix metalloproteinases (MMPs) that produced wrinkles. Black garlic is known to have an anti-aging ...

Abstract Silver nanoparticles show promise anticancer agents, yet their clinical translation is hindered by poor bioavailability and nonspecific toxicity. In this study, we developed an apigenin-functionalized silica-coa...

Abstract The plant Chenopodium opulifolium is traditionally consumed as a food and for treating ailments. Despite its use in Uganda for treating malaria, there are no scientific studies on its phytochemicals and biologic...

Colorectal cancer (CRC) ranks as the third most diagnosed cancer and the second leading cause of cancer-related mortality globally. Hexokinase II, a key rate-limiting enzyme in tumor glycolysis, is an important therapeut...

IntroductionIntestinal ischemia-reperfusion (I/R) injury, a common and severe clinical condition with high morbidity and mortality, burdens healthcare systems. Our previous investigations established that a nano-delivery...

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy in which immune dysregulation and metabolic remodeling are common features. Laminin subunit alpha 3 (LAMA3), a component of lamini...

Computer-aided drug discovery and design involve the use of information technologies to identify and develop, on a rational ground, chemical compounds that align a set of desired physicochemical and biological properties...

BackgroundCerebral ischemic injury includes ischemic stroke in adults and hypoxic-ischemic encephalopathy (HIE) in newborns. Delphinidin-3-O-glucoside (Dp3G) is a bioactive anthocyanin abundant in vibrantly colored plant...

Abstract Simultaneous inhibition of DNA gyrase and topoisomerase IV (Topo IV) is a primary pharmacological strategy to enhance antibacterial efficacy and markedly reduce the emergence of antibiotic resistance. In this re...

Abstract Background Hyperosmotic shock and the resulting cell volume compression are commonly experienced by organs such as the kidneys, causing rapid formation of hyperosmotic phase separation (HOPS) condensates in the ...

The prevalence rate of mortality in colorectal cancer is comparatively elevated. A standard or effective treatment has not been developed to resolve this issue. Utilizing Muntingia calabura, which is known to contain rut...

Phthalate plasticizers, especially diethyl phthalate (DEP), are linked to metabolic disorders, while their precise role and mechanism in diabetic nephropathy (DN) pathogenesis remain unclear. Here, we integrated transcri...

Abstract Fatty acid ethanolamides (FAEs) are bioactive lipids with amphiphilic properties and potential as prodrugs. In this study, a homologous series of FAEs (C8:0–C18:0) was evaluated for solubility, hydrophobicity,...

Abstract Background Olfactory detection of host odors is fundamental to mosquito host-seeking behavior. Although the olfactory pathways of model species such as Anopheles gambiae have been well characterized, the molecul...

Abstract Elevated levels of the gut-derived metabolite trimethylamine N-oxide (TMAO) are associated with atherosclerosis and thrombotic disorders, yet the molecular basis of its contribution to these pathologies remains ...

BackgroundSarcopenia, an age-correlated decline in skeletal muscle mass and function, has been increasingly linked to ferroptosis, which is an iron-dependent form of regulated cell death driven by lipid peroxidation. Nev...

Background The long-term biological effects of low-level exposure to artificial sweeteners remain debated. We integrated computational toxicology and Mendelian randomization (MR) to explore potential biological responses...

Abstract Background Gastrointestinal stromal tumors (GISTs) are primarily treated with tyrosine kinase inhibitors (TKIs) such as imatinib. However, the development of drug resistance remains a critical clinical challenge...