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116 resultados encontrados.

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Minimum Effective Volume of 0.25% Ropivacaine for Ultrasound-Guided Superior Trunk Block with Dexmedetomidine Sedation in Shoulder Arthroscopy: A Biased Coin Up-and-Down Trial
Artículo
Material complementario disponible Artículo DOAJ
Minimum Effective Volume of 0.25% Ropivacaine for Ultrasound-Guided Superior Trunk Block with Dexmedetomidine Sedation in Shoulder Arthroscopy: A Biased Coin Up-and-Down Trial
Wang K et al · Dove Medical Press · 2026 · ISSN 1177-8881
Kai Wang,1,2,* Shuhan Zhang,1,* Zhaoyu Lv,1,* Wei Chen,1 Yonghua Li1 1Department of Anesthesiology, Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital), Shanghai,...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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The Impact of Sex on the Median Effective Dose of Dexmedetomidine for Preoperative Sedation in Adults Undergoing Upper Limb Surgery: An Up-and-Down Sequential Allocation Study
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The Impact of Sex on the Median Effective Dose of Dexmedetomidine for Preoperative Sedation in Adults Undergoing Upper Limb Surgery: An Up-and-Down Sequential Allocation Study
Fan G et al · Dove Medical Press · 2026 · ISSN 1177-8881
Gaofei Fan, Mingming Han, Shudong Wang, Min Zhang, Fang Kang, Juan Li Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of C...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Anti-psoriatic and Anti-inflammatory Potentials of Phytochemicals from Curcuma longa against Interleukin-17A and Inducible Nitric Oxide Synthase: An In Silico Study
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Anti-psoriatic and Anti-inflammatory Potentials of Phytochemicals from Curcuma longa against Interleukin-17A and Inducible Nitric Oxide Synthase: An In Silico Study
Misbaudeen Abdul-Hammed et al · Universitas Gadjah Mada · 2024 · ISSN 1410-5918
LCC LCC:MedicineIdioma eng
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Dual-targeting phytochemicals Ergosterol and Quercetagetin implicate steroid metabolism–associated pathways in lung and liver cancer models
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Dual-targeting phytochemicals Ergosterol and Quercetagetin implicate steroid metabolism–associated pathways in lung and liver cancer models
Yujiao Chen et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
IntroductionHormone-associated cancers use steroid metabolism to grow and avoid the immune system, while traditional treatments have to deal with drug resistance and systemic toxicity.MethodsThis study is mainly divided ...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Small molecule stabilization of non-native protein-protein interactions of SARS-CoV-2 N protein as a mechanism of action against COVID-19
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Acceso abierto Artículo CONICET Digital
Small molecule stabilization of non-native protein-protein interactions of SARS-CoV-2 N protein as a mechanism of action against COVID-19
Fernández, Julián Francisco et al · Taylor & Francis · 2020 · ISSN 0739-1102
The outbreak of COVID-19, the disease caused by SARS-CoV-2, continues to affect millions of people around the world. The absence of a globally distributed effective treatment makes the exploration of new mechanisms of ac...
Idioma eng
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Using molecular embeddings in QSAR modeling: Does it make a difference?
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Using molecular embeddings in QSAR modeling: Does it make a difference?
Sabando, María Virginia et al · Oxford University Press · 2021 · ISSN 1467-5463
With the consolidation of deep learning in drug discovery, several novel algorithms for learning molecular representations have been proposed. Despite the interest of the community in developing new methods for learning ...
Idioma eng
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A scoping review of randomized controlled trials in the early phase of the COVID-19 pandemic: country-level research response to COVID-19 therapeutics and vaccines
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A scoping review of randomized controlled trials in the early phase of the COVID-19 pandemic: country-level research response to COVID-19 therapeutics and vaccines
Hiroki Saito et al · BMC · 2026 · ISSN 1471-2334
Abstract Backgrounds Clinical trials are central in pandemic preparedness and response (PPR). This scoping review aimed to illustrate the landscape of COVID-19-related randomized controlled trials (RCTs), focusing on the...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Carbohydrate-derived polytriazole nanoparticles enhance the antiInflammatory activity of cilostazol
Artículo
Material complementario disponible Artículo RI ITBA
Carbohydrate-derived polytriazole nanoparticles enhance the antiInflammatory activity of cilostazol
Rivas, M. Verónica et al · RI ITBA · 2023 · ISSN 2470-1343
"Poly(amide-triazole) and poly(ester-triazole) synthesized from d-galactose as a renewable resource were applied for the synthesis of nanoparticles (NPs) by the emulsification/solvent evaporation method. The NPs were cha...
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Development of hesperidin loaded lipid-chitosan nanoparticles: physicochemical characterization, molecular docking and ex vivo study
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Development of hesperidin loaded lipid-chitosan nanoparticles: physicochemical characterization, molecular docking and ex vivo study
Sadaf Jamal Gilani et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Hesperidin (HSP) is a bioactive flavonoid, and its activity is limited due to poor water solubility. We designed this research to develop and evaluate hesperidin nanoparticles (HSPNPs) to enhance drug release an...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Equity and representation in oncology clinical evidence for FDA-approved treatments and the impact of COVID-19
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Equity and representation in oncology clinical evidence for FDA-approved treatments and the impact of COVID-19
Hao Cheng et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
BackgroundPivotal clinical trials form the evidentiary foundation for FDA oncology drug approvals, yet persistent disparities in participant demographics may limit the generalizability and equity of cancer care. This stu...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Formulation and evaluation of transdermal patch of lidocaine HCl for insect bite
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Formulation and evaluation of transdermal patch of lidocaine HCl for insect bite
Arjmand Mushtaq et al · AMMANIF · 2023 · ISSN 2521-0521
Objective: Lidocaine needs to be administered frequently as it has poor oral bioavailability and it lacks prolong duration of action thus the study was aimed at to devise, develop, and analyze a matrix system transdermal...
LCC TENDOlBoYXJtYWN5IGFuZCBtYXRlcmlhIG1lZGljYQ~~Idioma eng
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Localized delivery of hyaluronic acid-doxorubicin from a surgical paste for post-operative glioblastoma treatment
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Localized delivery of hyaluronic acid-doxorubicin from a surgical paste for post-operative glioblastoma treatment
Giulia Rodella et al · Elsevier · 2026 · ISSN 2590-0064
Glioblastoma stem cells (GSCs) and residual tumor cells - which resist conventional therapies, drive disease recurrence, and contribute to the formation of an immunosuppressive tumor-immune microenvironment (TIME) - repr...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; LCC:Biology (General)Idioma eng
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Measuring thyroid-stimulating hormone receptor antibodies using the IMMULITE® 2000 TSI assay is better than using the BRAHMS TRAK assay in an unselected clinical population, but both perform worse than expected: a real-world retrospective observational study
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Measuring thyroid-stimulating hormone receptor antibodies using the IMMULITE® 2000 TSI assay is better than using the BRAHMS TRAK assay in an unselected clinical population, but both perform worse than expected: a real-world retrospective observational study
Sofia Manousou et al · BMC · 2026 · ISSN 1756-6614
Abstract Background Graves’ hyperthyroidism is caused by stimulatory autoantibodies. Its diagnosis and monitoring are commonly based on measurement of thyrotropin receptor antibodies (TRAb) with unspecific immunoassays...
LCC LCC:Diseases of the endocrine glands. Clinical endocrinologyIdioma eng
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Observational trial of the preventive impact of a social risk factor focused program for co-occurring opioid and methamphetamine use disorders and suicide risk in parents: study protocol
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Observational trial of the preventive impact of a social risk factor focused program for co-occurring opioid and methamphetamine use disorders and suicide risk in parents: study protocol
Lisa Saldana et al · BMC · 2026 · ISSN 1940-0640
Abstract Background Parents who experience adverse social risk factors of health (SRFOH) are at risk for child welfare involvement, and those with opioid and/or methamphetamine use (O/MU) and mental health (MH) disorders...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; LCC:Social pathology. Social and public welfare. CriminologyIdioma eng
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Pimobendan oral solution is bioequivalent to pimobendan chewable tablets in beagle dogs
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Pimobendan oral solution is bioequivalent to pimobendan chewable tablets in beagle dogs
Olaf Kuhlmann et al · Oxford University Press · 2025 · ISSN 0891-6640
Abstract Background Myxomatous mitral valve disease (MMVD) is frequently diagnosed in small breed dogs. Pimobendan oral solution has been developed to improve dosing accuracy in small and toy breed dogs. Hypothesis/Objec...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon
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Material complementario disponible Artículo RI ITBA
Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon
D'hers, Sebastián et al · RI ITBA · 2020 · ISSN 2190-393X
"Current emergency injectors of glucagon require manual reconstitution, which involves several steps that may lead to dosage errors. Rapid reconstitution packages (RRPs) are new devices, designed using computational flu...
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Recovery schools for improving behavioral and academic outcomes among students in recovery from substance use disorders: a systematic review
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Recovery schools for improving behavioral and academic outcomes among students in recovery from substance use disorders: a systematic review
Emily A. Hennessy et al · SAGE Publishing · 2018 · ISSN 1891-1803
This Campbell systematic review examines the effects of recovery schools on student behavioral and academic outcomes, compared to the effects of non‐recovery schools. The review summarizes evidence from one quasi‐exp...
LCC TENDOlNvY2lhbCBTY2llbmNlcw~~Idioma eng
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Revolutionizing herbal medicine delivery through phytosome technology
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Revolutionizing herbal medicine delivery through phytosome technology
Sonar P. Kumar · Libyan Association for Pharmacists · 2026 · ISSN 2958-3101
Herbal medicines have been extensively used for centuries owing to their therapeutic benefits and comparatively low incidence of adverse effects. Despite their clinical potential, the effectiveness of many herbal formula...
LCC TENDOlBoYXJtYWN5IGFuZCBtYXRlcmlhIG1lZGljYQ~~Idioma eng
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Safety and related factors of treatment with long-term atypical antipsychotic in Chinese patients with schizophrenia: observational study
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Safety and related factors of treatment with long-term atypical antipsychotic in Chinese patients with schizophrenia: observational study
Lei Zhang et al · Wiley · 2021 · ISSN 2517-729X
Background Atypical antipsychotics as first-line drugs have been used in patients with schizophrenia in China and abroad. However, its safety still needs to be evaluated in a large population, especially in Chinese patie...
LCC TENDOlBzeWNoaWF0cnk~Idioma eng
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Design and development of gastro retentive drug delivery System of tramadol hydrochloride
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Material complementario disponible Artículo SEDICI UNLP
Design and development of gastro retentive drug delivery System of tramadol hydrochloride
Rathore, Devashish et al · SEDICI UNLP · 2011
The present investigation concerns the development of floating tablets of tramadol hydrochloride, which after oral administration are designed to prolong the gastric residence time; improves the drug bioavailability, red...
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Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients
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Material complementario disponible Artículo SEDICI UNLP
Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients
Ige, Pradum P. et al · SEDICI UNLP · 2011
The aim of the present study was to develop sustained release swelling tablets containing metformin HCl and confine them into the stomach for enhancement of bioavailability. The different batches were manufactured by wet...
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Design, development and evaluation of immediate release gliclazide tablets
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Material complementario disponible Artículo SEDICI UNLP
Design, development and evaluation of immediate release gliclazide tablets
Mahjabeen, Sanjida et al · SEDICI UNLP · 2011
The aim of the current study was the design, development and optimization of oral immediate release solid dosage forms of gliclazide tablets, intended for rapid action within 30 min, formulated and optimized by in vitro ...
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Design, development and in vitro-in vivo study of colon specific fast disintegrating tablet based on time dependent approach
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Material complementario disponible Artículo SEDICI UNLP
Design, development and in vitro-in vivo study of colon specific fast disintegrating tablet based on time dependent approach
Kshirsagar, Sanjay J. et al · SEDICI UNLP · 2011
Targeted delivery systems for treatment of Inflammatory bowel disease (IBD) are designed to increase local tissue concentrations of anti-inflammatory drugs from lower doses compared with systemic administration The objec...
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Design of nimesulide-chitosan microparticles by pH change coacervation
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Material complementario disponible Artículo SEDICI UNLP
Design of nimesulide-chitosan microparticles by pH change coacervation
Khan, Shujaat A. et al · SEDICI UNLP · 2011
The present study involves the preparation of nimesulide-chitosan microparticles (NCM) as sustained delivery carriers with different polymer concentrations by pH change coacervation method using glutaraldehyde as cross-l...
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