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113 resultados encontrados.

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Efficacy and safety of Chinese botanical drug decoctions for migraine: a Bayesian network meta-analysis
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Efficacy and safety of Chinese botanical drug decoctions for migraine: a Bayesian network meta-analysis
Fan Zhang et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
BackgroundMigraine is a common neurological disorder that substantially affects patients’ quality of life. Chinese botanical drug decoctions are used in migraine management; however, the comparative efficacy and safety...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Formulation, development and evaluation of buccoadhesive drug delivery system of risperidone
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Formulation, development and evaluation of buccoadhesive drug delivery system of risperidone
Namra Chaudhary et al · AMMANIF · 2023 · ISSN 2521-0521
Aim and Objective: The study aimed to manufacture Bucco-adhesive tablets of Risperidone and characterize the effectiveness of the drug by incorporating it into the mucoadhesive drug delivery system. The sustained release...
LCC TENDOlBoYXJtYWN5IGFuZCBtYXRlcmlhIG1lZGljYQ~~Idioma eng
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GLP-1 agonist liraglutide decreases operant methamphetamine intake in rats under conditions of short- but not extended-access to the drug
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GLP-1 agonist liraglutide decreases operant methamphetamine intake in rats under conditions of short- but not extended-access to the drug
Maria Hrickova et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
ObjectiveGlucagon-like peptide-1 (GLP-1) receptor agonists have emerged as a therapeutic strategy for reducing drug craving and intake. However, their efficacy in methamphetamine use disorder remains unexplored. This stu...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Insights into the Value of the Market for Cocaine, Heroin and Methamphetamine in South Africa
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Insights into the Value of the Market for Cocaine, Heroin and Methamphetamine in South Africa
Andrew Scheibe et al · LSE Press · 2024 · ISSN 2516-7227
The illicit drug trade generates billions of dollars and sustains transnational criminal organisations. Drug markets can destabilise governance and undermine development. Data indicate increasing drug use in South Africa...
LCC LCC:Social pathology. Social and public welfare. Criminology; TENDOlNvY2lhbCBoaXN0b3J5IGFuZCBjb25kaXRpb25zLiBTb2NpYWwgcHIdioma eng
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Structure-enabled enhancement of potency in a metronidazole–benznidazole hybrid: design, synthesis, and evaluation of antitrypanosomal activity of a benzylamide-linked 5-nitroimidazole
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Structure-enabled enhancement of potency in a metronidazole–benznidazole hybrid: design, synthesis, and evaluation of antitrypanosomal activity of a benzylamide-linked 5-nitroimidazole
Afonso Santine M. M. Velez et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
Benznidazole (1) remains the primary antiparasitic drug used clinically for Chagas disease, underscoring the need to discover novel treatments targeting Trypanosoma cruzi (T. cruzi) infection. In this sense, the present ...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Application of antimalarial medications in the treatment of skin diseases
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Application of antimalarial medications in the treatment of skin diseases
Katarzyna M. Chyl-Surdacka et al · Termedia Publishing House · 2016 · ISSN 0033-2526
Antimalarial drugs used in medicine for over 300 years, nowadays, due to their anti-inflammatory, immunomodulatory and antiproliferative photoprotective properties, are used in the therapy of many dermatologic and rheuma...
LCC LCC:Medicine; LCC:DermatologyIdioma eng
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Decoding FGFR inhibitor sensitivity in cholangiocarcinoma with interpretable machine learning and cross-platform pharmacogenomic validation
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Decoding FGFR inhibitor sensitivity in cholangiocarcinoma with interpretable machine learning and cross-platform pharmacogenomic validation
Yading Xie et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
BackgroundFibroblast growth factor receptor (FGFR) inhibitors (FGFRis) benefit selected cholangiocarcinoma (CHOL) patients, yet responses remain heterogeneous and are not fully explained by canonical FGFR alterations. Cl...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Meta-analysis of the effects of exercise intervention on physical health in individuals undergoing compulsory isolation
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Meta-analysis of the effects of exercise intervention on physical health in individuals undergoing compulsory isolation
Zhiyao Zhang et al · Frontiers Media S.A · 2026 · ISSN 1664-0640
BackgroundPhysical health is the basic indicator to evaluate the health of drug addicts after the process of drug rehabilitation. In order to better improve the deficiency degree of physical health of drug addicts, it is...
LCC TENDOlBzeWNoaWF0cnk~Idioma eng
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Microneedle-based injection of Fungizone/Amphotericin B: an effective treatment for American cutaneous leishmaniasis in mice
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Microneedle-based injection of Fungizone/Amphotericin B: an effective treatment for American cutaneous leishmaniasis in mice
Ryan H. Huston et al · Taylor & Francis Group · 2026 · ISSN 1071-7544
Amphotericin B (AmB) is a potent, accessible, FDA-approved drug against CL with damaging side effects. While newer lipid formulations have less toxicity, limitations include affordability and cold-chain requirements. CL ...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Pathogenic characteristics of Vibrio parahaemolyticus O10:K4 in Guangdong Province from 2020 to 2022
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Pathogenic characteristics of Vibrio parahaemolyticus O10:K4 in Guangdong Province from 2020 to 2022
ZOU Min et al · The Editorial Office of Chinese Journal of Food Hygiene · 2025 · ISSN 1004-8456
ObjectiveTo investigate the drug resistance， molecular characteristics and prevalence of Vibrio parahaemolyticus O10：K4 in Guangdong Province from 2020 to 2022， and to provide evidence for the prevention and contro...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Nutrition. Foods and food supplyIdioma zho
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Software tool manage complex multiple dosage regimen calculations
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Software tool manage complex multiple dosage regimen calculations
Daniela Bismal et al · AMMANIF · 2025 · ISSN 2521-0521
In modern era of development health system conquer major issues linked with traditional way of calculating dose of patient. Advancement of pharmacokinetics based software ease calculation in clinical practice. A proper d...
LCC TENDOlBoYXJtYWN5IGFuZCBtYXRlcmlhIG1lZGljYQ~~Idioma eng
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Surface water quality contamination by selected residues of pharmaceuticals repurposed for Covid-19 treatment
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Surface water quality contamination by selected residues of pharmaceuticals repurposed for Covid-19 treatment
S. R. Maremane et al · Springer · 2026 · ISSN 2731-9431
Abstract Residues of pharmaceuticals are gradually accumulating in surface water resources because of the disposal of wastewater effluent. For the present study, four surface water resources (rivers and streams) that rec...
LCC TENDOkVudmlyb25tZW50YWwgc2NpZW5jZXM~Idioma eng
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Efficacy and Safety of Glecaprevir/Pibrentasvir in Participants with Chronic HCV Infection and Comorbidities or Multiple Concomitant Medications: An Integrated Analysis
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Efficacy and Safety of Glecaprevir/Pibrentasvir in Participants with Chronic HCV Infection and Comorbidities or Multiple Concomitant Medications: An Integrated Analysis
Curtis Cooper et al · Adis, Springer Healthcare · 2026 · ISSN 2193-8229
Abstract Introduction Glecaprevir/pibrentasvir (G/P) is globally approved for the treatment of chronic hepatitis C virus (HCV) infection and for acute HCV infection in the USA. The efficacy and safety of G/P has been cl...
LCC TENDOkluZmVjdGlvdXMgYW5kIHBhcmFzaXRpYyBkaXNlYXNlcw~~Idioma eng
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Fusing Specialized Surveys of Rare Populations to Larger Surveys for Generalized Inference: Cross-Sectional Survey Study
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Fusing Specialized Surveys of Rare Populations to Larger Surveys for Generalized Inference: Cross-Sectional Survey Study
Karilynn M Rockhill et al · JMIR Publications · 2026 · ISSN 1438-8871
Abstract BackgroundMainstays of pharmacoepidemiology are large, representative, behavioral surveys, which focus on many drugs with few detailed behaviors. Smaller, targeted studies measure drug-specific patte...
LCC TENDOkNvbXB1dGVyIGFwcGxpY2F0aW9ucyB0byBtZWRpY2luZS4gTWVkaWNhbCBpbmZvcm1hdGljcw~~; LCC:Public aspects of medicineIdioma eng
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Prescription compliance with National Formulary restrictions: Evaluation and information system–based strategies in an Indonesian tertiary hospital
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Prescription compliance with National Formulary restrictions: Evaluation and information system–based strategies in an Indonesian tertiary hospital
Elmiawati Latifah et al · Pensoft Publishers · 2026 · ISSN 2603-557X
The National Formulary plays a critical role in promoting rational drug use and controlling healthcare costs within Indonesia’s National Health Insurance system. Ensuring compliance with formulary restrictions, includi...
LCC TENDOlBoYXJtYWN5IGFuZCBtYXRlcmlhIG1lZGljYQ~~Idioma eng
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Profile and pattern of crack consumption among inpatients in a Brazilian psychiatric hospital
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Profile and pattern of crack consumption among inpatients in a Brazilian psychiatric hospital
Silvia Mendes da Cunha et al · Associação de Psiquiatria do Rio Grande do Sul · 2015 · ISSN 2238-0019
Introduction: Crack cocaine use is associated with polydrug abuse, and inpatients dependent on crack exhibit profiles of serious consumption patterns. Use of alcohol and tobacco and other drugs is a risk factor for exper...
LCC TENDOlBzeWNoaWF0cnk~Idioma eng
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Anticancer Synergy of Myricetin and Doxorubicin in Breast Cancer: Network Pharmacology and In Vitro Evaluation
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Anticancer Synergy of Myricetin and Doxorubicin in Breast Cancer: Network Pharmacology and In Vitro Evaluation
Roihatul Mutiah et al · Universitas Gadjah Mada · 2026 · ISSN 1410-5918
Breast cancer is a major public health problem worldwide, leading to an urgent need for the development of new strategies to improve treatment efficacy and manage drug resistance. Doxorubicin is among the most commonly u...
LCC LCC:MedicineIdioma eng
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Formulation and evaluation of mucoadhesive gastro-retentive tablets of domperidone
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Formulation and evaluation of mucoadhesive gastro-retentive tablets of domperidone
Drakhshaan Abdullah et al · AMMANIF · 2024 · ISSN 2521-0521
Objective: This study was aimed at the formation and evaluation of the mucoadhesive gastro-retentive tablet of domperidone to overcome the drawbacks related to the oral administration of drugs. These gastro retentive for...
LCC TENDOlBoYXJtYWN5IGFuZCBtYXRlcmlhIG1lZGljYQ~~Idioma eng
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Formulation and evaluation of transdermal patch of lidocaine HCl for insect bite
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Formulation and evaluation of transdermal patch of lidocaine HCl for insect bite
Arjmand Mushtaq et al · AMMANIF · 2023 · ISSN 2521-0521
Objective: Lidocaine needs to be administered frequently as it has poor oral bioavailability and it lacks prolong duration of action thus the study was aimed at to devise, develop, and analyze a matrix system transdermal...
LCC TENDOlBoYXJtYWN5IGFuZCBtYXRlcmlhIG1lZGljYQ~~Idioma eng
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Formulation, development and optimization of ofloxacin FDDS sustained release for UTI and H. pylori
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Formulation, development and optimization of ofloxacin FDDS sustained release for UTI and H. pylori
Muhammad Afnan et al · AMMANIF · 2024 · ISSN 2521-0521
Objective: Development & Optimization of Ofloxacin Floating tablets to enhance gastric retention time. Sustained release effect of formulation will reduce the dosing frequency for UTIs and prolonged local effect will ben...
LCC TENDOlBoYXJtYWN5IGFuZCBtYXRlcmlhIG1lZGljYQ~~Idioma eng
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Measuring thyroid-stimulating hormone receptor antibodies using the IMMULITE® 2000 TSI assay is better than using the BRAHMS TRAK assay in an unselected clinical population, but both perform worse than expected: a real-world retrospective observational study
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Measuring thyroid-stimulating hormone receptor antibodies using the IMMULITE® 2000 TSI assay is better than using the BRAHMS TRAK assay in an unselected clinical population, but both perform worse than expected: a real-world retrospective observational study
Sofia Manousou et al · BMC · 2026 · ISSN 1756-6614
Abstract Background Graves’ hyperthyroidism is caused by stimulatory autoantibodies. Its diagnosis and monitoring are commonly based on measurement of thyrotropin receptor antibodies (TRAb) with unspecific immunoassays...
LCC LCC:Diseases of the endocrine glands. Clinical endocrinologyIdioma eng
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DrugBank 5.0: a major update to the DrugBank database for 2018
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DrugBank 5.0: a major update to the DrugBank database for 2018
David S. Wishart; Yannick Djoumbou-Feunang; An Chi Guo; Elvis Lo; Ana Marcu; Jason R. Grant; Tanvir Sajed; Daniel L. Johnson · Nucleic Acids Research · 2017
DrugBank (www.drugbank.ca) is a web-enabled database containing comprehensive molecular information about drugs, their mechanisms, their interactions and their targets. First described in 2006, DrugBank has continued to ...
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Adverse drug reaction as cause of hospital admission of elderly people: a pilot study
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Adverse drug reaction as cause of hospital admission of elderly people: a pilot study
Varallo, Fabiana R. et al · SEDICI UNLP · 2011
The objective of this study was to estimate the prevalence of adverse drug reactions (ADR) related to hospital admission of elderly people, identifying the use of potentially inappropriate medication (PIM) , the ADR and ...
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Acute toxicity study of commercial antifungal drugs using Poecilia reticulata
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Acute toxicity study of commercial antifungal drugs using Poecilia reticulata
Mascotti, María L. et al · SEDICI UNLP · 2008
Commercial antifungal drugs possess important side effect; being toxicity the main limitation of such compounds. We report here a study of acute toxicity of four well-known commercial antifungal drugs; two of them used...
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