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Surface functionalization of cellulose nanocrystals (CNCs) is commonly used to improve their dispersibility, functionality, and performance across diverse applications. However, the potential biosafety risks of these mod...

The increase of automation in the aviation industry poses challenges to human performance. To attest this point, studies about aircraft accidents reveal that pilots’ response to automated systems is not always coherent...

Abstract Background AP01, a novel formulation of inhaled pirfenidone, has demonstrated potential for improved efficacy and safety for idiopathic pulmonary fibrosis (IPF) vs. oral pirfenidone. A 72-week phase 1b study, AT...

Human induced pluripotent stem cells (iPSCs) are transforming adoptive cell therapy by combining unlimited self-renewal, broad differentiation potential, and high amenability to genome engineering. These attributes make ...

Abstract Triticum dicoccum (Farro) an ancient wheat species has recently gained attention for its exceptional health benefits. However, research on its antibacterial and anti-biofilm properties remains limited. Additiona...

RNAi is a widely used methodology for gene silencing. The action mechanism of siRNA molecules has been well studiedin recent years, and the technique has been optimized in terms of safety and effectiveness. Cardiovascula...

Background Acute ischaemic stroke often leads to significant disability and mortality. Secondary brain injury caused by post-stroke immune and inflammatory responses worsens outcomes.Aim To assess the efficacy and safety...

The integration of Unmanned Aircraft Systems (UAS) into the National Air Space (NAS) in recent times has been met by mixed public responses. The paper establishes four constructs each of which encapsulates multiple backg...

Velvet antler, a valued traditional medicine of animal origin, contains an abundance of bioactive compounds including amino acids, peptides, proteins, and nucleosides. It exhibits notable health-promoting properties such...

Abstract Large language models (LLMs) like ChatGPT and DeepSeek are gaining attention for their potential in medical education. This study aims to evaluate the performance of ChatGPT and DeepSeek in the United States Med...

BackgroundTo evaluate the clinical significance of regulatory dual-channel digestive tract reconstruction with a pylorus-preserving approach in advanced gastric cancer through a multicenter study.MethodsA total of 137 ga...

Abstract Eleusine coracana (L.) Gaertn., commonly known as Ragi or finger millet, is a nutrient-rich cereal traditionally valued for its health-promoting properties. However, its precise molecular mechanisms and therapeu...

Background Adherence to clinical guidelines is central to patient safety in oral surgery, yet guideline uptake in routine dental practice remains inconsistent. Traditional guideline formats, such as static PDF documents,...

BackgroundOn-demand gene editing of autologous cells offers a novel therapeutic option for inborn errors of immunity (IEIs) caused by dominant-negative variants, which are often poorly addressed by conventional viral gen...

Pharmacogenetics has redefined the understanding of antidepressant response by demonstrating that genetic variability profoundly influences both drug efficacy and safety. This review synthesizes current evidence on the i...

Abstract Knee osteoarthritis (KOA) is a degenerative joint condition characterized by progressive cartilage deterioration and chronic pain, leading to functional impairment. Bone marrow-derived orthobiologics, such as bo...

Abstract The CRISPR‐Cas system constitutes an adaptive immune mechanism in prokaryotes that defends against mobile genetic elements. Within the perpetual co‐evolutionary arms race between bacteria and their viral pre...

BackgroundRobot-assisted simple prostatectomy (RASP) and laser enucleation of the prostate (LEP) are established surgical options for the treatment of large-volume benign prostatic hyperplasia (BPH); however, consensus r...

Credible election has become a critical requirement for democracy and good governance. The safety of the environment in which the election is conducted is also necessary for acceptability of the outcome of the election. ...

ObjectiveThe method of high performance liquid chromatography （HPLC） was developed to study the detection of synthetic colorants in natural pigments and condiment.MethodsThe analytes were extracted by direct ultrason...

Abstract Parasitic diseases such as malaria, leishmaniasis, and schistosomiasis remain difficult to treat due to the pathogens’ complex life cycles, intracellular niches, and resistance to conventional therapies. Tradi...

Este início do século coloca-nos diante de graves questões que nos impõem a necessidade de repensar as bases do tipo de sociedade que queremos. O espaço da liberdade reduz-se progressivamente a um ato de consumo e a...

Matcha green tea, a powdered whole-leaf preparation from shade-grown Camellia sinensis, exhibits a unique biochemical profile rich in catechins (particularly EGCG), L-theanine, caffeine, and chlorophyll, distinguishing i...

BackgroundRadical prostatectomy remains a key curative treatment for localized prostate cancer which has undergone continuous transformation. Recent developments in robot-assisted and single-port surgery have followed th...