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In the last years, hairy root (HR) cultures are gaining attention in the biotechnology industry. This particular plant cell culture derives from explants infected with Agrobacterium rhizogenes. They constitute a relative...

While studying familial celiac disease, we identified four individuals with a rare heterozygous loss-of-function variant in the highly conserved, early-evolved ABCF1 gene. In addition, the 246 individuals heterozygous fo...

The discovery of oil in the late 1950s marked a turning point for the United Arab Emirates, as it transformed into a global metropolis, breaking regional and international records in urban development and infrastructure ...

Abstract Background Developing regenerative therapies to restore kidney function in patients with progressive renal disease represents a major challenge for modern molecular nephrology. Kidney organoids, three-dimensiona...

Cobalamin (vitamin B12) is a vitamin with a defined role in human metabolism. Since its discovery in the 20th century, our understanding of its deficiency that results in multifaceted disorders with a significant impact ...

Abstract Background Genetic aberrations are among the critical driving factors of lung cancer. Importantly, the impact of genetic variations on proteomic dysregulations with the goal of characterizing potential diagnosti...

The search strategy or the discovery of new effects for heavy neutrinos often rely on their different decay channels to detectable particles. In particular, in this work we study the decay of a Majorana neutrino with int...

ABSTRACT: In recent years, the use of computing has increased along with medical skills, and this had impressive results in terms of classification and treatment, in addition to facilitating the matter of medical personn...

Diabetes is a chronic systemic disease affecting 8.3% of the general population, thus constituting an important clinical and financial problem for healthcare systems throughout the world. Complications of diabetes damage...

The lithic assemblages recorded from shell middens along the northern coast of Santa Cruz, Argentine Patagonia, reveal some common trends. In general terms, abundant debris, and a few tools and cores have been identified...

Abstract Background Drug-induced liver injury (DILI) remains a significant barrier to the safe and efficient use of antimalarial medicines. Many promising compounds fail in late-stage development or post-marketing owing ...

The genus Sonoita Peckham & Peckham, 1903 is recorded in Gujarat State for the first time with discovery of the species Sonoita lightfooti G.W. Peckham & E.G. Peckham, 1903 in the Kachchh region. A detailed diagnosis is ...

Abstract Objective Abnormalities in the eutopic endometrium of women with endometriosis may be related to disease-associated infertility. Although previous RNA-sequencing analysis did not show differential expression i...

BackgroundThe ubiquitin–proteasome pathway is a critical therapeutic target in malignancies, particularly multiple myeloma. The development of proteasome inhibitors (PIs) has marked a milestone in multiple myeloma ther...

In his essays on general history, Patočka locates the thaumatical shake-up together with the beginning of philosophy, politics, and history in classical Greece, when man first stepped back from being and became able to ...

Abstract In response to the emerging threat of insecticide resistance in malaria vectors, insecticides are being repurposed for vector control or developed de novo. The longevity of disease control programs will require ...

Introduction Understanding the relative risk of the fragile X messenger ribonucleoprotein 1 (FMR1) premutation (PM) versus the risk of the PM and parenting a child with fragile X syndrome (FXS) is critical for PM carrier...

Constitui-se o presente trabalho da transcrição integral da palestra realizada pelo Dr. Harald Sioli (1910-2004) no Seminário da Amazônia, em 10 de agosto de 1990, quando numa última viagem ao Amazonas, ao completar...

This paper draws upon a detailed longitudinal survey of households living on agricultural plots in the northern three provinces of the Ecuadorian Amazon, the principal region of colonization by migrants in Ecuador since ...

Abstract Androgen receptor (AR) is a therapeutic target for prostate cancer. Despite effectively targeting its folded ligand-binding domain (LBD), resistance ultimately develops by mechanisms involving reactivation of AR...

We report the occurrence of Bungarus walli Wall, 1907, for the first time from Northeast India, based on morphological and meristic examination of an uncollected specimen encountered during a herpetofaunal survey in Raim...

ABSTRACT Most species of Myxobolus (Cnidaria: Myxozoa) infect freshwater and marine fish, and cause sporozoosis. Passage of myxozoan parasites into human feces has been described occasionally. We examined fecal samples f...

In the growing diversity of human induced pluripotent stem cell (iPSC)-derived models of brain development, we present here a novel method that exhibits 3D cortical layer formation in a reproducible topography of minimal...

Abstract In the present paper we study the relationship between the notions of force, cause and subject of motion in Leibniz’s early dynamics. First, we specify the role that the problem of the subject and cause of mot...