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CCR7 immune cell receptor expression in inflammatory breast cancer
Artículo
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CCR7 immune cell receptor expression in inflammatory breast cancer
Jennifer H. Chen et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Inflammatory breast cancer (IBC) is characterized by congestion of dermal lymphovascular spaces by tumor emboli. We characterized expression of CCR7, a lymphocyte homing chemokine receptor, in IBC cell lines and...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Identification of a telomere-aging-related gene as a novel prognostic factor for intrahepatic cholangiocarcinoma: Machine learning-aided biomarker discovery and experimental verification
Artículo
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Identification of a telomere-aging-related gene as a novel prognostic factor for intrahepatic cholangiocarcinoma: Machine learning-aided biomarker discovery and experimental verification
Jianjian Yin et al · Elsevier · 2026 · ISSN 2472-6303
Background: Intrahepatic cholangiocarcinoma (ICC) is an aggressive hepatobiliary malignancy characterized by a complex pathogenesis and poor prognosis. Telomere dysfunction and cellular senescence are involved in the pat...
LCC TENDOkJpb3RlY2hub2xvZ3k~; TENDOk1lZGljYWwgdGVjaG5vbG9neQ~~Idioma eng
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MicroRNA expression in the cerebrospinal fluid of dogs with and without cervical spondylomyelopathy
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MicroRNA expression in the cerebrospinal fluid of dogs with and without cervical spondylomyelopathy
Daniella P. Vansteenkiste et al · Oxford University Press · 2019 · ISSN 0891-6640
Abstract Background Osseous‐associated cervical spondylomyelopathy (OA‐CSM) is a common condition of the cervical vertebral column that affects giant dog breeds. MicroRNAs (miRNAs) are small RNAs that regulate gene e...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Network analyses reveal shifts in transcript profiles and metabolites that accompany the expression of sun and an elongated tomato fruit
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Network analyses reveal shifts in transcript profiles and metabolites that accompany the expression of sun and an elongated tomato fruit
Clevenger, Josh P. et al · American Society Of Plant Biologist · 2015 · ISSN 1164-1178
SUN controls elongated tomato (Solanum lycopersicum) shape early in fruit development through changes in cell number along the different axes of growth. The gene encodes a member of the IQ domain family characterized by ...
Idioma eng
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Nitric oxide-repressed Forkhead factor FoxE1 expression is involved in the inhibition of TSH-induced thyroid peroxidase levels
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Nitric oxide-repressed Forkhead factor FoxE1 expression is involved in the inhibition of TSH-induced thyroid peroxidase levels
Montesinos, Maria del Mar et al · Elsevier Ireland · 2016 · ISSN 0303-7207
Thyroid peroxidase (TPO) is essential for thyroid hormone synthesis mediating the covalent incorporation of iodine into tyrosine residues of thyroglobulin process known as organification. Thyroid-stimulating hormone (TSH...
Idioma eng
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Overcrowding Stress in Livestock Production Alters Gut Microbiota Composition and Neuronal Nitric Oxide Synthase (nNOS) Expression in nNOS-HiBiT Knock-in Mouse Model
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Overcrowding Stress in Livestock Production Alters Gut Microbiota Composition and Neuronal Nitric Oxide Synthase (nNOS) Expression in nNOS-HiBiT Knock-in Mouse Model
Soyoung Yeo et al · Springer Nature · 2025 · ISSN 2636-0772
Abstract Overcrowding stress in livestock farming is a significant concern for animal health and livestock products such as meats, milk, and eggs. It affects gut health by altering microbiota and regulating neuronal nitr...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Animal cultureIdioma eng
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Significance of Methyltransferase-like 5 Expression in Oral Squamous Cell Carcinoma
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Significance of Methyltransferase-like 5 Expression in Oral Squamous Cell Carcinoma
Yuka Kajiya et al · Elsevier · 2026 · ISSN 0020-6539
Objectives: Oral squamous cell carcinoma (OSCC) is a malignant tumour with high-local invasiveness and lymph node metastasis potential. It is associated with poor prognosis and postoperative cosmetic complications. There...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
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The impact of exercise on gene regulation in association with complex trait genetics
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The impact of exercise on gene regulation in association with complex trait genetics
Nikolai G. Vetr et al · Nature Portfolio · 2024 · ISSN 2041-1723
Abstract Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study and largely restricted to analyses of either few or ...
LCC TENDOlNjaWVuY2U~Idioma eng
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β-Hydroxybutyrate upregulates hepatic histone β-hydroxybutyrylation modification, promotes the expression of PPARα, and alleviates the hepatic steatosis in MASLD
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β-Hydroxybutyrate upregulates hepatic histone β-hydroxybutyrylation modification, promotes the expression of PPARα, and alleviates the hepatic steatosis in MASLD
Dongze Li et al · BMC · 2026 · ISSN 1868-7083
Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) stands as the most widespread chronic liver disorder globally. Histone β-hydroxybutyrylation (Kbhb)—a novel post-translational modif...
LCC LCC:Medicine; LCC:GeneticsIdioma eng
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Comparison of the chondrogenic differentiation potential of bone marrow mesenchymal stem cells between female and male Wistar rats
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Comparison of the chondrogenic differentiation potential of bone marrow mesenchymal stem cells between female and male Wistar rats
L.P. Romão et al · Universidade Federal de Minas Gerais, Escola de Veterinária · 2024 · ISSN 1678-4162
ABSTRACT This study aimed to compare the chondrogenic differentiation potential between bone marrow mesenchymal stem cells from female (fBMSCs) and male (mBMSCs) Wistar rats. For this purpose, female and male BMSCs were ...
LCC LCC:Animal cultureIdioma eng
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GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection
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GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection
Ortiz Wilczyñski, Juan Manuel et al · Public Library of Science · 2020 · ISSN 1553-7366
Multiple sclerosis (MS) is a highly disabling neurodegenerative autoimmune condition in which an unbalanced immune response plays a critical role. Although the mechanisms remain poorly defined, helminth infections are kn...
Idioma eng
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Impact of L-arginine and L-citrulline supplementation on macrophage responses to Mycobacterium tuberculosis
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Impact of L-arginine and L-citrulline supplementation on macrophage responses to Mycobacterium tuberculosis
Gunapati Bhargavi et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
L-arginine (ARG) availability is a critical determinant of macrophage antimicrobial capacity, as it fuels nitric oxide production and other immune effector pathways essential for restricting Mycobacterium tuberculosis (M...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Lipidomics of allantoic fluid collected by allantocentesis indicates a possible mechanism underlying partial litter loss in multifetal pregnancies of ewes
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Lipidomics of allantoic fluid collected by allantocentesis indicates a possible mechanism underlying partial litter loss in multifetal pregnancies of ewes
Tamir Alon et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Fetal mortality significantly impacts reproductive efficiency in sheep, with approximately 30% of fetuses failing to survive until lambing. In multifetal gestation, partial litter loss (PLL) occurs in 28% to 37%...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Association between the expression of amphetamine-induced behavioral sensitization and Cdk5/p35 activity in dorsal striatum
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Association between the expression of amphetamine-induced behavioral sensitization and Cdk5/p35 activity in dorsal striatum
Mlewski, Estela Cecilia et al · American Psychological Association · 2016 · ISSN 0735-7044
Sensitization to psychostimulants is strongly influenced by the environmental context in which the drug is administered and little is known about the molecular mechanisms that regulate this process. Chronic treatment wit...
Idioma eng
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Autologous Ex Vivo Lentiviral Gene Therapy for Pediatric Patients with Severe Leukocyte Adhesion Deficiency-I Provides Sustained Efficacy with a Favorable Safety Profile
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Autologous Ex Vivo Lentiviral Gene Therapy for Pediatric Patients with Severe Leukocyte Adhesion Deficiency-I Provides Sustained Efficacy with a Favorable Safety Profile
Claire Booth et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundSevere leukocyte adhesion deficiency-I (LAD-I) results from biallelic deleterious ITGB2 variants leading to deficient/defective CD18 leukocyte expression and impaired endothelial adhesion and extravasation.Chil...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Computational multi-omics integration suggests an association between LAMA3 expression, immune suppression, and metabolic programs in pancreatic ductal adenocarcinoma
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Computational multi-omics integration suggests an association between LAMA3 expression, immune suppression, and metabolic programs in pancreatic ductal adenocarcinoma
Ruixiang Li et al · Springer · 2026 · ISSN 2730-6011
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy in which immune dysregulation and metabolic remodeling are common features. Laminin subunit alpha 3 (LAMA3), a component of lamini...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Effects on Goat Meat Extracts on α-Glucosidase Inhibitory Activity, Expression of Bcl-2-Associated X (BAX), p53, and p21 in Cell Line and Expression of Atrogin-1, Muscle Atrophy F-Box (MAFbx), Muscle RING-Finger Protein-1 (MuRF-1), and Myosin Heavy Chain-7 (MYH-7) in C2C12 Myoblsts
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Effects on Goat Meat Extracts on α-Glucosidase Inhibitory Activity, Expression of Bcl-2-Associated X (BAX), p53, and p21 in Cell Line and Expression of Atrogin-1, Muscle Atrophy F-Box (MAFbx), Muscle RING-Finger Protein-1 (MuRF-1), and Myosin Heavy Chain-7 (MYH-7) in C2C12 Myoblsts
Joohyun Kang et al · Springer Nature · 2023 · ISSN 2636-0772
Abstract This study examined the α-glucosidase inhibitory, and apoptosis- and anti-muscular-related factors of goat meat extracts from forelegs, hind legs, loin, and ribs. The goat meat extracts were evaluated for their...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Animal cultureIdioma eng
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Human alpha defensin 5 expression in the human kidney and urinary tract.
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Human alpha defensin 5 expression in the human kidney and urinary tract.
John David Spencer et al · Public Library of Science (PLoS) · 2012 · ISSN 1932-6203
BackgroundThe mechanisms that maintain sterility in the urinary tract are incompletely understood. Recent studies have implicated the importance of antimicrobial peptides (AMP) in protecting the urinary tract from infect...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B
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Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B
Fangfang Li et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
BackgroundChronic hepatitis B (CHB) caused by the hepatitis B virus (HBV) remains a major global health burden. The immune-active (IA) phase, characterized by positive Hepatitis B surface antigens (HBsAg), elevated alani...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways
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Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways
Barrientos, Gabriela Laura et al · W B Saunders Co Ltd · 2015 · ISSN 0143-4004
Introduction: The development of the human haemochorial placenta requires complex regulatory mechanisms to protect invasive trophoblast cells from cytotoxic responses elicited by maternal immune cells. Leptin, the adipoc...
Idioma eng
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Low GBX2 expression is associated with histological type B thymoma: a multi-omics analysis
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Low GBX2 expression is associated with histological type B thymoma: a multi-omics analysis
Zheng Lu et al · Springer · 2026 · ISSN 2730-6011
Abstract Objective To explore new diagnostic markers and therapeutic targets associated with the histological types of thymoma. Methods The TCGA and GEO was used to gather genomic and clinical data from thymoma patients....
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Novel Pathogenic Variant in IL2RG Affecting the Signal Peptide Results in mRNA Instability, Decreased IL2RG Expression, and Atypical Late-Onset Immunodeficiency
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Novel Pathogenic Variant in IL2RG Affecting the Signal Peptide Results in mRNA Instability, Decreased IL2RG Expression, and Atypical Late-Onset Immunodeficiency
Muslima Hussain et al · Rockefeller University Press · 2026 · ISSN 3065-8993
X-linked severe combined immunodeficiency (SCID-X1) presents as T-B+NK- SCID, due to mutations in the common γ chain (IL2RG/CD132), a shared component of several cytokine receptors. Without definitive therapy, SCID-X1 i...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Peripheral Expression of FOXP3 in Brazilian Patients with IPEX Syndrome: From FOXP3 Biomarker to Targeted FOXP3 Therapy Within the CNE3I
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Peripheral Expression of FOXP3 in Brazilian Patients with IPEX Syndrome: From FOXP3 Biomarker to Targeted FOXP3 Therapy Within the CNE3I
Leonardo Oliveira Mendonça et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic disorder caused by loss-of-function mutations in the FOXP3 gene, which is critical for the development of functional regulato...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Unexpected modulation of Hna phage defense activity by the symbiotic regulator NolR
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Unexpected modulation of Hna phage defense activity by the symbiotic regulator NolR
Leah M. Sather et al · American Society for Microbiology · 2025 · ISSN 0021-9193
ABSTRACT The Hna phage defense system is one of many systems that protect bacteria against bacterial viruses (phages). Hna was first discovered in the nitrogen-fixing alphaproteobacterium Sinorhizobium meliloti, which fo...
LCC LCC:MedicineIdioma eng
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