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The Iwo Eleru skeleton is the only Pleistocene human fossil currently known from Western Africa. Previously, we showed morphological affinities of the Iwo Eleru cranial remains with Pleistocene archaic African specimens,...

I focus on the concept of the receptive field of a sensory neuron, taking it as a prominent case to address conceptual change in the history of neuroscience. I argue for an interpretation of its role and evolution based ...

Deficiency of adenosine deaminase 2 (DADA2) was identified in 2014 as a novel inborn error of immunity caused by biallelic pathogenic variants in ADA2. DADA2 patients express two predominant clinical phenotypes: (1) auto...

Abstract As a core node for maintaining the ecological security of the Bohai Sea and promoting the coordinated development of regional social economy, the Yellow River Estuary has long been subjected to the dual stress o...

Systematic tool use is a central component of the human niche. However, the timing and mode of its evolution remain poorly understood. A newly developed method for the analysis of muscle recruitment patterns (Validated E...

Throughout history, our capacity to shed tears has attracted the attention of poets, writers, philosophers, and scholars. Moreover, humans' fascination with tears is evident in the significant roles they played in legend...

Many of the names used by specialists in studies of hominin evolution are outside the formal Linnaean classification governed by the International Code of Zoological Nomenclature. These non-Linnaean names include many of...

IntroductionDNGR-1 (CLEC9A), a C-type lectin receptor specifically expressed on human BDCA3+ and murine CD8α+/CD103+ conventional type 1 dendritic cells (cDC1), acts as a damage-associated molecular pattern (DAMP) recep...

A rising human impact alters landscape patterns and determines the agriculture–ecology–economy nexus (AEEN), which further threatens the sustainability of social–ecological system (SES). However, the mechanisms thr...

This study investigates how the Fourth Industrial Revolution (IR 4.0) strengthens the tourism industry through the evolution of smart tourism ecosystems (STE). As one of key economic sectors, tourism requires technology-...

With its theoretical basis firmly established in molecular evolutionary and population genetics, the comparative DNA and protein sequence analysis plays a central role in reconstructing the evolutionary histories of spec...

The Molecular Evolutionary Genetics Analysis (MEGA) software has matured to contain a large collection of methods and tools of computational molecular evolution. Here, we describe new additions that make MEGA a more comp...

We present the latest version of the Molecular Evolutionary Genetics Analysis (Mega) software, which contains many sophisticated methods and tools for phylogenomics and phylomedicine. In this major upgrade, Mega has been...

The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available ...

We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genom...

Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this diversity remains unexplained, although di...

Bowtie is an ultrafast, memory-efficient alignment program for aligning short DNA sequence reads to large genomes. For the human genome, Burrows-Wheeler indexing allows Bowtie to align more than 25 million reads per CPU ...

We present here a framework for the study of molecular variation within a single species. Information on DNA haplotype divergence is incorporated into an analysis of variance format, derived from a matrix of squared-dist...

Abstract Self-determination theory (SDT) maintains that an understanding of human motivation requires a consideration of innate psychological needs for competence, autonomy, and relatedness. We discuss the SDT concept of...

A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp DNA sequence was generated over 9 months fr...

Se presentan los primeros resultados tendientes a caracterizar genéticamente la población antigua que ocupaba el actual territorio de la Provincia de Córdoba a través del estudio de haplogrupos del ADN mitocondrial e...

Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA sequence changes. Here we describe the aggregation and analysis of high-quality exome (protein-...

Materias / palabras clave: Molecular clock; Biology; Mitochondrial DNA; Evolutionary biology; Sequence (biology); Gorilla; Hominidae; Divergence (linguistics); Zoology; Paleontology; Ancient DNA; Biological evolution