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Influenza A, an acute or subacute respiratory infectious disease caused by the influenza A virus (IAV), affects humans and animals, and poses a serious threat to public health. Currently, IAV prevention and treatment rel...

BackgroundB cell Expansion with NF-κB Activation and T cell Anergy (BENTA) disease is a rare inborn error of immunity caused by gain-of-function (GOF) variants in CARD11. It is characterized by early-onset lymphadenopat...

The IKAROS family of zinc finger transcription factors (IKZF1–4) plays a central role in lymphocyte development and immune regulation. Pathogenic IKZF1 variants produce a wide phenotypic spectrum related to whether the...

Background22q11.2 deletion syndrome (DS) is the most common chromosomal microdeletion syndrome and a leading cause of developmental delay, congenital heart disease, and varying degrees of T cell immunodeficiency. While m...

STAT3 signaling is fundamental to T cells, where it underlies basic cellular processes like metabolism and apoptosis, as well as specialized processes like effector differentiation and cytokine production. However, mutat...

Background and AimsSepsis is a common complication in patients with hematological malignancies that occurs during chemotherapy treatment, which in turn leads to acquired immunodeficiency. In recent years, increasing atte...

Human papillomavirus (HPV) is a DNA virus with oncogenic potential. Persistent infections with high-risk HPV genotypes can drive malignant transformation in multiple tissues, resulting in distinct HPV-associated cancers....

Transposable elements (TEs) make up almost half of the human genome and are among its most densely methylated regions. Their epigenetic silencing is crucial for genomic stability and immune homeostasis, and accumulating ...

ObjectiveEarly recognition of inborn errors of immunity (IEI) is critical to avoid morbidity and irreversible organ damage. Jeffrey Modell Foundation (JMF) warning signs have long guided and still guide clinical suspicio...

X-linked inhibitor of apoptosis (XIAP) is essential for innate and adaptive immune responses, including programmed cell death inhibition, NFkB and MAPK activation, NLRP3 inflammasome activity regulation, and TNFR signali...

Materias / palabras clave: Firmicutes; Bacteroidetes; Biology; Obesity; Microbiome; Gut flora; Metagenomics; Bacteria; Physiology; Immunology; Genetics; Gene

BACKGROUND AND METHODS: National surveillance data show recent, marked reductions in morbidity and mortality associated with the acquired immunodeficiency syndrome (AIDS). To evaluate these declines, we analyzed data on ...

BACKGROUND/AIMS: Human parvovirus B19 (B19V) may cause inflammatory cardiomyopathy (iCMP) which is accompanied by endothelial dysfunction. The B19V capsid protein VP1 contains a lysophosphatidylcholine producing phosphol...

BACKGROUND: Pulmonary endothelial injury is a critical process in the pathogenesis of acute lung injury (ALI) during sepsis. Heat shock protein A12B (HSPA12B) is mainly expressed in endothelial cells and protects against...

The simultaneous measurement of multiple modalities represents an exciting frontier for single-cell genomics and necessitates computational methods that can define cellular states based on multimodal data. Here, we intro...

Putative endothelial cell (EC) progenitors or angioblasts were isolated from human peripheral blood by magnetic bead selection on the basis of cell surface antigen expression. In vitro, these cells differentiated into EC...

Materias / palabras clave: immunotherapy, immunology, epidemiology, pharmaco-economics, vaccines; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy; Medicine: Therapeutics. Pharmacology

Materias / palabras clave: human immunology, human diseases, immunotherapy, autoimmunity; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Materias / palabras clave: food biochemistry, food microbiology, nutrition and immunology, food safety, food safety and toxicology; Technology: Home economics: Nutrition. Foods and food supply

Materias / palabras clave: prevention, diagnosis and management of human diseases, pathology, immunology, hereditary disease, physiological disease; Medicine

Materias / palabras clave: human pathology, oncology, molecular biology, biochemistry, immunology, genetics; Medicine: Pathology