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ObjectiveThe aim of the study was to examine the relationships between dietary intake of amino acids and the risk of hypertension and to find some important amino acids as the targets of intervention in Chinese children ...

The COVID-19 pandemic prompted several drug repositioning initiatives with the aim to rapidly deliver pharmacological candidates able to reduce SARS-CoV-2 dissemination and mortality. A major issue shared by many of the ...

Abstract Locoregional CAR-T delivery is increasingly explored for glioblastoma to improve intracranial tumor exposure; however, organ-level biodistribution kinetics after intracranial administration remain poorly quantif...

Thermoplastic polymers have emerged as compelling alternatives to conventional thermosets in response to increasing environmental concerns, primarily due to their superior recyclability and enhanced sustainability charac...

Abstract Broadband Power Line Communication (BB-PLC) technology enables data transmission for smart grid applications. Nevertheless, channel equalizers are required in the receiver to estimate and compensate for the nonl...

Optimization methods are valuable for making decisions and identifying the most suitable alternative based on a given objective function. One of the mathematical optimization methods is Conjugate Gradient (CG) method whi...

The operational efficiency of fleet aircraft employed for student flight training in collegiate aviation programs is strongly influenced by scheduling, among other factors. The average utilization rate for the fleet oper...

Powder compaction is the most widely used technology to fabricate polymer bonded explosives (PBX), and its parameters significantly influence the structures and mechanical properties of the final products. By conducting ...

Water-scarce smallholder regions require irrigation strategies that are both biophysically credible and socially legitimate. We propose an integrated hydro-economic decision-support framework for the Cesar Department (Co...

The knowledge and the ability to describe the phase equilibrium behavior of systems composed of transesterification products are very important in the optimization of biodiesel production and purification process. In thi...

Abstract Microrobotic systems offer significant potential for precision medicine by enabling minimally invasive interventions in complex fluidic environments. However, effective operation in these settings requires actua...

Source-grid-load-storage coordinated operation control is an operation mode and technology that can maximize the utilization of energy resources, and can economically, efficiently and securely improve the power dynamic b...

The seismic load has an adverse effect on the bearing capacity of the footings. However, few studies are performed to study its impact on the bearing capacity of slopes. In this study, a rigorous analysis in the framewor...

Abstract In the realm of ultra-intense laser physics, the precise characterization of laser pulses is indispensable for ensuring optimal peak power and experimental fidelity. However, accurate measurement of spatiotempor...

Alteration of muscle activation sequence is a key mechanism in heart failure with reduced ejection fraction. Successful cardiac resynchronization therapy (CRT), which has become standard therapy in these patients, is lim...

Materias / palabras clave: Maxima and minima; Computer science; Robustness (evolution); Image registration; Artificial intelligence; Global optimization; Interpolation (computer graphics); Optimization problem; Computer vision; Motion (physics); A...

Materias / palabras clave: Maxima and minima; Computer science; Robustness (evolution); Image registration; Artificial intelligence; Interpolation (computer graphics); Global optimization; Computer vision; Optimization problem; Motion (physics); A...

Materias / palabras clave: Least-squares function approximation; Mathematics; Applied mathematics; Non-linear least squares; Calculus (dental); Mathematical optimization; Statistics; Explained sum of squares; Medicine; Dentistry; Estimator

Previous article Next article An Algorithm for Least-Squares Estimation of Nonlinear ParametersDonald W. MarquardtDonald W. Marquardthttps://doi.org/10.1137/0111030PDFPDF PLUSBibTexSections ToolsAdd to favoritesExport Ci...

The objective of the present study was to develop an oral timed-released press-coated tablet containing theophylline as a model drug. A D-optimal design of experiment was employed to systematically study the effect of te...

In this Ph. D thesis, the main significant contributions are: formulation of a new non-linear membership function using fuzzy approach to capture and describe vagueness in the technological coefficients of constraints in...

Maximum likelihood or restricted maximum likelihood (REML) estimates of the parameters in linear mixed-effects models can be determined using the lmer function in the lme4 package for R. As for most model-fitting functio...

Many areas of science depend on exploratory data analysis and visualization. The need to analyze large amounts of multivariate data raises the fundamental problem of dimensionality reduction: how to discover compact repr...

In this article, we present a new LINear Constraint Solver (LINCS) for molecular simulations with bond constraints. The algorithm is inherently stable, as the constraints themselves are reset instead of derivatives of th...