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Circadian rhythms are essential for maintaining intervertebral disc (IDD) homeostasis and regulate cellular metabolism, mechanical responses, and therapeutic efficacy. Core clock genes, especially CLOCK and BMAL1, have c...

Abstract Metamaterials are defined as artificially designed micro-architectures with unusual physical properties, including optical, electromagnetic, mechanical, and thermal characteristics. This study investigates the c...

Fowl adenovirus serotype 11 (FAdV-11) causes inclusion body hepatitis, posing a persistent threat to poultry health. However, the genetic determinants governing its pathogenicity remain unclear. Comparative analysis of p...

Abstract Periodontitis is the most prevalent chronic inflammatory condition affecting oral health and is associated with long treatment duration. It is triggered by microbial plaque, which leads to localized and diffuse ...

The mowed lawn grass generated by lawn mowing accumulates as a thatch layer. The thatch layer clogging the turf and providing a hotbed for pathogens causes various obstacles toward the turf. The purpose of this study is ...

Abstract Re-entrant auxetic lattices exhibiting negative Poisson’s ratio behaviour are attractive for lightweight energy-absorbing applications. However, traditional re-entrant and hexagonal auxetic designs often exhib...

Abstract Bone fracture healing requires coordinated regulation of osteogenesis, angiogenesis, and immune homeostasis within a dynamically evolving microenvironment. However, current biomaterials rarely integrate these th...

Herpesvirus of turkey (HVT) recombinant vector vaccines are widely used in the poultry industry. However, due to limitations in loading multiple foreign antigens into a single HVT vector, other viral vectors are urgently...

Objective: To develop a targeted delivery to the fungal affected cells. The present study focus on developing, optimizing, and evaluating a novel Niosomal loaded nail lacquer formulation for increasing the transdermal ...

ABSTRACT Proton exchange membrane water electrolysis (PEMWE) is a compelling route for sustainable green hydrogen production. Yet Ir‐based oxygen evolution reaction (OER) catalysts suffer from a persistent trade‐off ...

Inorganic materials contain remarkable properties for drug delivery, such as a large surface area and nanoporous structure. Among these materials, CaCO3 microparticles (CMPs) exhibit a high encapsulation efficiency and s...

Previously we showed that orally administered Lactobacillus rhamnosus CRL1505 beneficially regulated the balance between pro- and anti-inflammatory mediators in the lungs of poly(I:C)-challenged mice, allowing an effecti...

Immunotherapy has made great progress in recent years while most cancer patients cannot benefit from it. Photochemotherapy combination strategy holds great promise for developing novel immunotherapy for the patients bear...

L-arginine (ARG) availability is a critical determinant of macrophage antimicrobial capacity, as it fuels nitric oxide production and other immune effector pathways essential for restricting Mycobacterium tuberculosis (M...

Changing gel structure and immobilization conditions led to a significant improvement in the covalent multipoint attachment of chymotrypsin on chitosan. The use of sodium alginate, gelatin, or κ-carrageenan, activation ...

Abstract Objective Klebsiella pneumoniae (Kp) is a clinically prevalent opportunistic pathogen, with escalating antimicrobial resistance posing substantial challenges. Current vaccine strategies are constrained by the...

Abstract GH 3230 superalloy is a solution strengthening nickel-based superalloy and it is commonly used for fabricating hot components with the service temperature of above 900 ℃. In order to further improve high-tempe...

Left ventricular hypertrophy (LVH) is an enlargement of the left ventricle caused by chronically increased hemodynamic load, such as arterial hypertension or aortic stenosis. In the initial stages, LVH has a protective n...

Glioblastoma (GBM) is the most common and aggressive type of central nervous system cancer, characterized by high rates of recurrence and mortality. As the highest-grade glioma, patient prognosis remains poor despite mul...

Bladder cancer is a highly malignant tumor with limited treatment options. Although adoptive cell therapy has shown promise in oncology, its efficacy is often constrained by poor intrinsic antitumor activity and a highly...

Optical lattices (OLs) with conventional spatial periodic λ/2, formed by interfering the counterpropagating laser beams with wavelength λ, are versatile tools to study the dynamical and static properties of ultracold a...

Abstract Scavenging excess reactive oxygen species (ROS) and positively improving intestinal dysbiosis is a promising therapeutic strategy for alleviating inflammatory bowel disease (IBD). However, conventional clinical ...

ABSTRACT Background HIV is a significant aetiological factor in thrombotic microangiopathy (TMA) in regions of high seroprevalence, but description of HIV‐associated TMA (HIV‐TMA) remains limited to small case series...

BackgroundBehçet’s disease is a multisystem inflammatory disorder whose diagnosis can be challenging due to overlapping features with other inflammatory conditions and primary immunodeficiencies (1). In patients with ...