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RationaleHypogammaglobulinemia increases the risk of life-threatening bacterial infections that require antibiotic treatment in pediatric patients. Only a handful of studies have looked at the prevalence of allergies in ...

Background: Despite high cure rates in pediatric B-cell acute lymphoblastic leukemia (B-ALL), relapse remains a major challenge. Current risk stratification systems fail to identify a subset of occult high-risk (HR) pati...

Malignant solid tumors of the gastrointestinal tract are clinically rare in children, with malignant solid tumors of the esophagus being particularly uncommon. Clinical reports on esophageal cancer in children are extrem...

A 10-year-old patient was admitted to the pediatric sub-intensive care unit due to massive rectal bleeding and severe acute anemia. His medical background included Asperger syndrome and a history of chronic constipation ...

Lloyd M Halpern,1 Zackary Correll,2 De-An Zhang,3 Clark J Kogan,4 Kirk A Ryan,5 Ted Sousa6 1Department of Anesthesia, Shriners Children’s Hospital, Spokane, WA, USA; 2Department of Medicine, University of Washington Sc...

Background. Pediatric abdominal pain accounts for more than 1 million emergency department (ED) visits annually, and appendicitis is the most common surgical emergency. Guidelines recommend ultrasound as the initial imag...

BackgroundUrolithiasis in pediatric populations is increasing worldwide, with environmental and social determinants playing key roles. In Mexico, Yucatan is an endemic area for urolithiasis in adults. However, pediatric ...

This study was designed to evaluate the effects of CAPD and/or uremia on carbohydrate (ch) and lipid metabolism in pediatric chronic renal failure (predialysis (PD) and CAPD) patients, compared to an age-matched controls...

Purpose. To demonstrate the effectiveness of combined surgery including calcific band keratopathy (CBK) treatment followed by cataract extraction with intraocular lens (IOL) implantation in pediatric patients, assessed t...

Abstract Background Children with congenital and acquired heart disease (CAHD) are at high risk for venous thromboembolism (VTE). Traditional anticoagulants such as vitamin K antagonists (VKAs) and low-molecular-weight h...

Objective To compare the outcome of rectal and surface electrode stimulation, when performed concomitantly with routine anal sphincter (AS) exercises and bio-feedback training, in children who have received corrective su...

Com o objetivo de modificar a escala de coma de Glasgow pediátrica para utilização na medicina veterinária, foram utilizados 30 cães adultos com alterações neurológicas passíveis de avaliação da consciência. ...

Importance Emergency departments (EDs) face significant documentation burdens due to reliance on unstructured clinical narratives, hindering efficiency, particularly in pediatric care. Large language models (LLMs) offer ...

IntroductionAlthough immune responses to Bacillus Calmette–Guérin (BCG) vaccination and susceptibility to mycobacterial infection vary across individuals, the underlying cellular mechanisms regulating this heterogenei...

BackgroundX-linked hyper IgM syndrome (XHIGM) is a rare primary immunodeficiency (PID) caused by pathogenic variants in the CD40 ligand (CD40LG) gene, resulting in defective immunoglobulin class-switch recombination, cau...

Background and AimsPediatric lymphoproliferative disorders (LPD), both malignant and nonmalignant, may conceal underlying inborn errors of immunity (IEI), yet systematic screening is rarely performed. We hypothesized tha...

Purpose: To evaluate the long-term outcomes of Intrastromal Corneal Ring Segments (ICRS) implantation in pediatric patients with keratoconus.  Methods: Retrospective analysis of eyes with ICRS implantation in pediatri...

ObjectivePatients seen for uncontrolled seizures in a Pediatric Emergency Department (ED) often undergo tracheal intubation (TI). We looked at factors associated with TI in children in a safety net hospital.MethodsThis w...

Objective: This study aimed to assess the histopathological diagnosis of pediatric renal biopsies performed at the tertiary referral center in the city and to compare the ultrasound (USG) -guided biopsy and percutaneous ...

Sepsis remains one of the most complex and lethal syndromes in pediatric critical care, driven by dysregulated and heterogeneous host responses to infection. Despite decades of biomarker research, few biomarkers have bee...

BackgroundValproic acid (VPA) is widely used in pediatric epilepsy, but its blood concentrations vary considerably among pediatric patients with epilepsy. This study aimed to investigate the factors influencing VPA blood...

Kun-Yin Qiu,1,2,* Xiong-Yu Liao,1,2,* Hai-Lei Chen,2,3,* Hong Zheng,1,2,* Jian-Pei Fang,1,2 Dun-Hua Zhou1,2 1Department of Hematology/Oncology, Children’s Medical Center, Sun Yat-sen Mem...

Abstract Background Bacterial urinary tract infections (UTIs) are among the most common bacterial infections in children. The prevalence and etiological patterns of pediatric UTIs vary based on demographic and environmen...

Abstract Background Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is generally milder in children than adults, but concerns remain regarding potential long-term pulmonary sequelae, even in non-pneumonic case...