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We propose that the excitability margin (ΔVmargin), defined as the difference between spike threshold and resting membrane potential, may function as a quantitative gating variable linking chronic stress, inflammatory l...

Background Previous studies have shown that educational attainment (EA), intelligence and income are key factors associated with mental disorders. However, the direct effects of each factor on major mental disorders are ...

Background The role of human lineage mutations (HLMs) in human evolution through post-transcriptional modification is unclear.Aims To investigate the contribution of HLMs to human evolution through post-transcriptional m...

Evidence from both GWAS and clinical observation has suggested that certain psychiatric, metabolic, and autoimmune diseases are heterogeneous, comprising multiple subtypes with distinct genomic etiologies and Polygenic R...

Background: India faces a substantial mental health treatment gap, with national estimates indicating that 70–90% of individuals with mental disorders do not receive adequate care. Contributing factors include stigma, ...

Abstract Background Women in prison with culturally and linguistically diverse (CALD) backgrounds are at higher risk of marginalisation, isolation, and discrimination than non-CALD women. Despite this, the mental health ...

Background The well-known ‘pyrotherapy’ of Julius Wagner-Jauregg might be the beginning of the study on the immunological concepts of schizophrenia. As the primary immune effector cells in the brain, microglia play a...

Psychotic manifestations of brain tumours are rare but described in the literature mostly along with other neurological deficits. Memory loss, difficulty in attention and concentration, depression, anxiety, and mood symp...

Restless legs syndrome (RLS) is a common sleep-related movement disorder characterised by an uncomfortable urge to move the legs that occurs during periods of inactivity. Although there have been many case reports on ant...

Abstract Background The use of antipsychotic drugs has increased in recent years, extending beyond traditional indications like schizophrenia and bipolar disorder while the use of lithium has remained stable or declined....

Objective: To report the rare development of manic symptoms in a patient with schizophrenia and discuss its differential diagnosis.Case description: Diagnostic criteria were based on the International Classification of D...

Abstract Language plays a central role in the assessment of individuals with psychosis, from taking a medical history to evaluating cognitive function. However, speaking multiple languages can significantly influence lin...

Abstract Thalamocortical circuits regulate information flow between sensory inputs and higher-order processing, and their disruption is increasingly implicated in psychotic disorders. However, scalable biomarkers of this...

The GABAergic neurotransmission is a highly conserved system that has been attributed to various regulatory events. There has been a notable number of studies on the importance of GABAergic neurotransmission, both excita...

Materias / palabras clave: psychiatry, schizophrenia, anxiety, depressive disorders; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system: Psychiatry

Materias / palabras clave: psychiatry, mental health, medicine, mental disorder, schizophrenia, bipolar; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system: Psychiatry