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Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but ...

Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an undifferentiated state. We show that four factors (OCT4, SOX2, NANOG, and LIN28) are suffic...

Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal ti...

Materias / palabras clave: Biology; Induced pluripotent stem cell; Cell biology; Stem cell; Embryonic stem cell; Genetics; Gene

Materias / palabras clave: Homeobox protein NANOG; Biology; SOX2; Embryonic stem cell; Induced pluripotent stem cell; Reprogramming; KOSR; Cell biology; Stem cell; Embryoid body; Induced stem cells; Rex1

Materias / palabras clave: Biology; Stem cell; Cell biology; Elasticity (physics); Matrix (chemical analysis); Cell lineage; Computational biology; Evolutionary biology; Cellular differentiation; Genetics; Gene; Physics

Materias / palabras clave: Biology; Epithelial–mesenchymal transition; Stem cell; Mesenchymal stem cell; Cancer stem cell; Epithelium; Cell biology; Metastasis; Cancer research; Cell; Cell culture; Cancer

Materias / palabras clave: stem cell research, hematology, oncology, stem cell transplantion; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens

Materias / palabras clave: stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, genomics and translational research; Medicine: Internal medicine

ABSTRACT Bactris trunks are made entirely by long sustained primary growth so that mechanical properties develop progressively as the trunk matures. Anatomical features vary throughout the stem so that one small sample i...

Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with rising global prevalence. Current management strategies predominantly address behavioral symptoms rather than core neurobi...

ABSTRACT Despite the significance of adipose-derived stem cells in complementary and regenerative medicine, studies regarding clinical safety for allogeneic intravenous administration in healthy dogs remain insufficientl...

Abstract Cultured meat is under investigation as an environmentally sustainable substitute for conventional animal-derived meat. Employing a scaffolding technique is one approach to developing cultured meat products. The...

Drug discovery research faces significant challenges, with around 90 % of candidate drugs failing in clinical trials. Traditional animal models do not always accurately reflect human physiology and pathology, leading to ...

IntroductionThe limited availability of suitable scaffolds for three-dimensional (3D) cell culture has driven the development of new biomaterials. In this study, we developed a porcine fibrin matrix gel (PFMG) derived en...

Abstract Bone defects present significant challenges in clinical practice due to the limitations of traditional treatments. Compared to traditional cell therapies, exosome-based therapies have emerged as a promising alte...

Abstract Tuberculosis (TB) remains a major global public health challenge, with drug-resistant tuberculosis (DR-TB) presenting a serious threat to TB management. Conventional treatment faces challenges such as significan...

Subretinal delivery of retinal pigment epithelium (RPE) cells is an important treatment for retinal degeneration patients, and the cell suspension method is the most common approach. Injectable hydrogel-mediated cell eng...

OBJECTIVE: Stem cells may be involved in the repair processes of renal tissues during various disorders. We aimed to search the presence of recipient originated cells in renal allograft tissues from patients with various...

Abstract Chimeric antigen receptor (CAR) T cell therapies have achieved clinical success in autologous treatment of hematological malignancies. However, their broader application remains limited. Beyond the biological ch...

Abstract Cystinosis is a systemic lysosomal storage disease resulting from mutations in the CTNS gene encoding the lysosomal cystine transporter cystinosin, leading to cystine accumulation in all organs. Despite cystinos...

Abstract Background Variants in OTUD5 are associated with neurodevelopmental disorders (NDDs), yet the underlying molecular mechanisms remain unclear. This study aimed to investigate the pathogenicity of a novel OTUD5 va...

Abstract Background Inflammatory bowel disease (IBD) represents a group of chronic and relapsing inflammatory disorders of the gastrointestinal tract, primarily encompassing Crohn’s disease (CD) and ulcerative colitis ...

Abstract Fetal bovine serum (FBS), which contains various nutrients, comprises 20% of the growth medium for cell-cultivated meat. However, ethical, cost, and scientific issues, necesitates identification of alternatives....