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La ingeniería de software es una ciencia relativamente nueva, tan nueva como el concepto de software en sí. Como toda ciencia, evoluciona constantemente, crece, incorpora nuevas herramientas, metodologías y conceptos....

Many methodologies have been proposed to systematize the software development process. Many of them have been widely adopted. However, the majority has focused on analysis and design. Requirements have frequently been fo...

In this paper we describe a methodology to translate BON (architectural) designs to Alloy specifications. The main virtue of this process is that it can be implemented by means of software tools. The utilization of this ...

Structural equation modeling (SEM) is a vast field and widely used by many applied researchers in the social and behavioral sciences. Over the years, many software packages for structural equation modeling have been deve...

Macromolecular X-ray crystallography is routinely applied to understand biological processes at a molecular level. However, significant time and effort are still required to solve and complete many of these structures be...

An account is given of the development of the SHELX system of computer programs from SHELX-76 to the present day. In addition to identifying useful innovations that have come into general use through their implementation...

Abstract Motivation: Robust large-scale sequence analysis is a major challenge in modern genomic science, where biologists are frequently trying to characterize many millions of sequences. Here, we describe a new Java-ba...

MOTIVATION: A new protocol for sequencing the messenger RNA in a cell, known as RNA-Seq, generates millions of short sequence fragments in a single run. These fragments, or 'reads', can be used to measure levels of gene ...

BACKGROUND: Correlation networks are increasingly being used in bioinformatics applications. For example, weighted gene co-expression network analysis is a systems biology method for describing the correlation patterns a...

Materias / palabras clave: software engineering, software architecture, software testing, distributed computing, software design, software development; Science: Mathematics: Instruments and machines: Electronic computers. Computer science: Compute...

Materias / palabras clave: artificial intelligence, applied computer systems, data encryption, model driven software development, programming technologies, software engineering; Science: Mathematics: Instruments and machines: Electronic computers....