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The purpose of the present investigation was to prepare gellan-chitosan polyelectrolyte complex beads in one step and to explore the potential of the prepared beads in the oral delivery of metronidazole (log P = 0.0) and...

The goal of any drug delivery system is to provide a therapeutic amount of drug (s) to the proper site in the body in order to promptly achieve and there by to maintain the desired drug concentrations during treatment. T...

The present study involves preparation and characterization of floating multiparticulate microcapsules with Simvastatin as model drug for prolongation of gastric residence time. The main objective is to improve solubilit...

A camptotecina (CPT) é um fármaco de elevada atividade antitumoral cujo uso na terapêutica tem sido limitado devido a sua baixa solubilidade aquosa e elevada instabilidade após administração intravenosa. Buscando c...

Sodium alginate microspheres of domperidone for intranasal systemic delivery were developed to eliminate first pass metabolism, improve patient compliance and obtain improved therapeutic efficacy in treatment of migrai...

Se prepararon nanopartículas poliméricas conteniendo tretinoína por el método de depósito interfacial de polímero preformado. Para el ensayo de actividad antiproliferativa se utilizaron: tretinoína en forma de sol...

Benzocaine (BZC) is an ester-type local anesthetic used mainly in topical, dermal and mucosal formulations. The present work consists of the development and validation of analytical methodology for evaluation of benzocai...