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Abstract Background Left atrioventricular coupling index (LACI) has been recognized for its prognostic significance across various cardiovascular diseases; however, its role in non-ischemic dilated cardiomyopathy (NIDCM)...

Objective: To explore the imaging biomarkers obtained from baseline multi-modality imaging PET/CT before metastasis-directed therapy (MDT), which could offer early response prediction before MDT treatment, optimizing pat...

Abstract Background This study aims to evaluate the effectiveness and real-world applicability of total neoadjuvant therapy (TNT) in patients with locally advanced rectal cancer (LARC), focusing on pathological complete ...

Abstract Background Rapid and accurate markers to aid diagnosis of sepsis are needed in neonatal foals. The CBC variable red blood cell distribution width (RDW) to platelet ratio (RPR) is associated with inflammatory res...

Abstract Background The current AJCC staging system for breast cancer categorizes all distant metastases under a monolithic M1 designation, failing to capture profound heterogeneity in outcomes. This study aimed to devel...

ABSTRACT Background Outcome‐based cardiac risk stratification schemes are lacking for preclinical myxomatous mitral valve disease (MMVD). The Mitral INsufficiency Echocardiographic (MINE) score was developed as an easy...

ABSTRACT Objective Lifelong cumulative high low‐density lipoprotein cholesterol (LDL‐C) levels are associated with atherosclerosis burden. This study analyzed the association between cumulative LDL‐C levels and the...

Abstract Background To evaluate the risk of Retinal Artery Occlusion (RAO) in individuals with Primary-Open Angle Glaucoma (POAG) using a large-scale real-world database. Methods This retrospective cohort study used the ...

Abstract Objective “One-stop” interventional therapy for non-valvular atrial fibrillation (NVAF) traditionally relies on transesophageal echocardiography (TEE) guidance, which carries limitations including anesthe...

OBJECTIVE: Secondary arteriovenous fi stula (AVF) management with saphenous vein (SV) graft and basilic vein transposition (BVT) in HD-dependent patients are good alternatives. A concurrent series of patients was reviewe...

Abstract Background Prognostic assessment in sepsis involves evaluating the dynamic progression of organ dysfunction and the inflammatory response. This study compared the predictive value of serially measured serum HMGB...

Abstract Background Triple-negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic targets. Hypoxia, autophagy, apoptosis, and translational stress are key biological processes involved in tumor p...

BackgroundNon–Down syndrome acute megakaryoblastic leukemia (non–DS–AMKL) is a rare but high-risk subtype of pediatric AML with dismal outcomes. Allo-HSCT in first complete remission (CR1) is recommended as the pre...

IgA nephropathy is one of the most widely seen glomerulonephritides. It is one of the major causes of end stage renal disease. The aim of this study was to determine the clinical, biochemical, properties, treatment modal...

This study is performed in Istanbul University Cerrahpaşa Medical Faculty Haemodialysis Unit. 172 patients (mean age 45 years; 109 males, 63 females) regularly dialysed for at least longer than 3 months in our unit betw...

Objective: To profile telomere-related genes (TRGs) to develop a robust prognostic tool for stomach adenocarcinoma (STAD) and explore their associations with immune regulation and treatment response. Methods: A total of ...

Category: Hindfoot, Ankle Arthritis Keywords: Wound Complications, Total Ankle Arthroplasty, Revision Ankle Arthroplasty Introduction/Purpose: Total ankle arthroplasty (TAA) preserves motion, while ankle arthrodesis (AF)...

Introduction and aims: Oral microbial biomarkers for metabolic syndrome (MetS), in contrast to its well-characterized relationship with the gut microbiome, have not been well defined. This study aims to systematically id...

Background: The United Network for Organ Sharing mandates a psychosocial assessment of transplant candidates before listing. A quantified measure for determining transplant candidacy is the Psychosocial Assessment of Can...

Abstract Background Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy characterized by rapid progression and poor prognosis. This study integrates bioinformatics with experimental validation to cha...

Abstract Introduction The role of peripheral blood basophil (PBB) and their telomere length (TL) in the pathogenesis and prognosis of hepatocellular carcinoma (HCC) patients has not been fully studied. The correlation be...

Abstract This study aimed to evaluate the cost-effectiveness of Penpulimab versus placebo in treating metastatic squamous non-small cell lung cancer (NSCLC) from the perspective of Chinese payers. A three-state Markov mo...

Abstract Purpose The purpose of this study was to examine whether Ki67-scores have a predictive significance for pathological complete response (pCR) and invasive disease-free survival (IDFS) in HER2-positive breast canc...

Abstract Objectives Gastrointestinal neuroendocrine neoplasms (GI-NENs) exhibit heterogeneity in biological behavior, making it difficult to predict prognosis. We established the P Grade based on 68Ga-DOTANOC and 18F-FDG...