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BackgroundCisplatin-induced acute kidney injury (CI-AKI) is a severe, dose-limiting nephrotoxicity affecting up to 30% of patients. Emerging evidence highlights ferroptosis—an iron-dependent form of regulated cell deat...

Acne vulgaris is a common inflammatory skin condition that affects up to 85% of adolescents and is primarily driven by Cutibacterium acnes (anaerobic bacteria, formerly Propionibacterium acnes). With the rise of antibiot...

Abstract Objective Myelodysplastic syndromes (MDS) are associated with a high risk of progression to leukemia, highlighting the critical need to explore novel therapeutic agents. Based on network pharmacology predicti...

Next generation risk assessment (NGRA) demands a fundamental transformation in how toxicological test methods are validated. Traditional validation approaches, designed for animal tests and mainly for simple in vitro met...

Abstract Chocolate milk is one of the most commonly used non-fermentative dairy products, which, due to high level of sucrose, could lead to diabetes and tooth decay among children. Therefore, it is important to replace ...

En el artículo se analiza el papel de las emociones en la configuración de las prácticas de extensionistas rurales y en procesos territoriales que impulsan. El estudio es de tipo exploratorio y analiza las prácticas ...

Background: Hyperglycemia, characterized by elevated blood glucose levels, leads to oxidative stress and pancreatic β-cell dysfunction. Streptozotocin (STZ)-induced hyperglycemia in mice is widely used to model pancreat...

One of the reasons why investors were not prepared for heavy losses in the stock markets that occurred after the beginning of sub prime mortgage crisis in the US lies in the curious fact that many practitioners were led ...

Background: Combining radiotherapy (RT) with immune checkpoint inhibitors (ICIs) offers potential synergy through RT-induced immunogenic cell death and enhanced systemic immunity. However, optimal RT dose, fractionation,...

IntroductionEarly and accurate diagnosis of skin cancer has a huge impact on the survival rate of patients and deep learning-based CNN and dermatologists' intelligence support can fasten the diagnosis not only within the...

Most works on the sociology of the future, presented mainly in the fields of Western sociology, are based on the epistemology of methodological individualism and the theory of rational choice. This means that the expecte...

"Retinoblastoma is the most common intraocular tumor in childhood. Topotecan has been widely used as an antineoplastic agent for retinoblastoma treatment. Topotecan penetration into living tumorspheres is quantified usin...

Agents repesent a new paradigm for developing software applications. In spite of the interest of this particular way of looking at problems, there is considerable discrepancy on exactly what is an agent and which are the...

Negotiation is a basic mechanism for interaction that allows the members in a Multiagent System to coordinate their actions and to reach a favorable agreement. When agents are collaborative, the negotiation process progr...

Q-Learning is a Reinforcement Learning method for solving sequential decision problems, where the utility of actions depends on a sequence of decisions and there exists uncertainty about the dynamics of the environment t...

In this paper we show an algorithm for dynamic reconfiguration of distributed applications based on the mobile agent model. We also show that the proposed algorithm can be easily implemented in the IPL language, a langua...

This paper discusses the main lines used to model intelligent agents that will operate in a Collaborative Online Learning Environment-COLE. The aim of COLE is to evaluate the contribution that Information Technology and ...

When certain enterprise domain needs to make an unusual decision, it will probably require new kind of information. If the interaction model among domains cannot be defined because the decision scenarios are unpredictabl...

Los precios de los commodities han evidenciado un notable crecimiento en los últimos años, lo que ha traído consigo un sinnúmero de cambios en la economía mundial. Este trabajo busca efectuar un aporte dentro de est...

Los precios de los commodities han evidenciado un notable crecimiento en los últimos años, lo que ha traído consigo un sinnúmero de cambios en la economía mundial. Este trabajo busca efectuar un aporte dentro de est...

This work presents an interaction model among collaborative agents based on dialogues. For the specification we use a formalism, called Dialogue Games, which allows to describe the nature of the utterances available in e...

An accurate procedure for evaluating the strong correlation and conflicting goals of coverage, capacity and Quality of Service (QoS) is required for efficient planning of 3G radio networks. In this paper, we explore and ...

Fil: Ayarza, Joaquín Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. El tratamiento d...

Fil: Bell, Martin. Universidad de Sussex. Unidad de Investigación en Política Científica; Inglaterra. Gran parte del marco intelectual y de la estructura institucional para la política científica y tecnológica que ...