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Introduction and aims: Increasing evidence suggests that marginal zone B and B1 cell-specific protein (MZB1) plays crucial roles in inflammatory responses, endoplasmic reticulum (ER) stress, and cell survival, but its fu...

The constitutive androstane receptor (CAR) modulates the transcription of numerous genes involving drug metabolism, energy homeostasis, and cell proliferation. While rodent studies suggest an oncogenic role for murine CA...

Background: Spinal cord injury (SCI) has emerged as a major challenge to global public health due to its low recovery rate and high disability rate, making the development of novel therapeutic approaches imperative. Mese...

Mitochondrial dysfunction is a convergent hallmark of biological aging and a mechanistically attractive target for gerotherapeutic development. Yet translation of mitochondria-focused interventions has been limited by pa...

Symbiont bacteria associated with Polycarpa aurata are known to produce secondary metabolites with diverse bioactive properties, including antibacterial, anticancer, antifungal, and antiprotozoal activities. This study e...

The accurate identification of taxa of Aotus is essential for 1) the development of precise biomedical assays, 2) the determination of potential illegal traffic of this genus, and 3) conservation. Although many studies h...

Abstract This study introduces a multiplex high-resolution melting (mHRM) assay for efficient sex identification of Cannabis sativa L. using three MADC markers and nine SCAR markers. This method enables accurate and rapi...

Nanotechnology is growing at an exponential rate and will undoubtedly have both beneficial and toxicological impact and consequences on health and environment. Amphibians are being increasingly used for toxicity screenin...

Plant irritability for light stimuli becomes crucial to cope with ambient fluctuations in order to keep up homeostasis and accomplish the life cyclesuccessfully. Light environment governs plant development. Perception of...

Abstract The IL-6 signalling pathway plays a significant role in the progression and development of squamous cell carcinoma (SCC). Bazedoxifene is a potent inhibitor of IL-6R; however, its efficacy is limited by its low ...

Abstract Background Type 1 diabetes (T1D) is a lifelong autoimmune condition characterised by the progressive immune-mediated destruction of insulin-secreting β-cells within the pancreatic islets, culminating in absolut...

Developing effective drugs for Alzheimer’s Disease (AD) is critically limited by insufficient brain exposure. To address this, structural optimization was employed to balance physicochemical properties and enhance bloo...

Acquired hemophilia A (AHA) is a rare, potentially life-threatening autoimmune bleeding disorder characterized by the development of inhibitory autoantibodies against factor VIII (FVIII). While most commonly diagnosed in...

Background: Combined antiretroviral treatment (cART) for HIV infection is highly effective in controlling viral replication. However, it cannot achieve a sterilizing cure. Several strategies have been proposed to achieve...

Abstract Since their discovery, bacteriophages—viruses that infect bacteria—have been invaluable to molecular biology and biotechnology. Renewed interest in phage-based antimicrobials, driven by the global antibiotic...

Abstract Background Previous studies have indicated that chronic emotional stressors likely participate in the occurrence of cancers. However, direct evidence connecting stress and colorectal cancer development remains a...

Through cell-based screening models, we have identified a new compound IMB5043, a thiophenylated pyridazinone, which exerted cytotoxicity against cancer cells. In the present study, we evaluated its antitumor efficacy an...

Abstract Background The bark beetle Ips typographus (Coleoptera: Curculionidae: Scolytinae) is a major pest of spruce trees in Central Europe. Its ecological success is mediated by a male-produced aggregation pheromone, ...

The antagonistic Bacillus subtilis K1, previously isolated in our laboratory, exhibited significant inhibitory activity against Botrytis cinerea. To investigate the underlying molecular mechanisms, genomic bioinformatics...

A method development aimed for high-throughput and automated antibody screening holds great potential for areas ranging from fundamental molecular interactions to the discovery of novel disease markers, therapeutic targe...

BackgroundPatients admitted to intensive care units are frequently exposed to pathogenic microorganisms present in their environment. Exposure to these microbes may lead to the development of hospital-acquired infections...

The IKAROS family of zinc finger transcription factors (IKZF1–4) plays a central role in lymphocyte development and immune regulation. Pathogenic IKZF1 variants produce a wide phenotypic spectrum related to whether the...

To explore more potential fungicides with new scaffolds, 10 norbornene derivatives containing thiourea group were designed, synthesized and assayed for inhibitory activity against three plant pathogenic fungi. The prelim...

Abstract Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and poses a significant threat to public health. Traditional treatments often lead to poor prognoses and tum...