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Cobalamin (vitamin B12) is a vitamin with a defined role in human metabolism. Since its discovery in the 20th century, our understanding of its deficiency that results in multifaceted disorders with a significant impact ...

Myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) are natural compounds involved in many biological pathways. Since the discovery of their involvement in endocrine signal transduction, myo-Ins and D-chiro-Ins sup...

ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and...

Introduction: The development of the human haemochorial placenta requires complex regulatory mechanisms to protect invasive trophoblast cells from cytotoxic responses elicited by maternal immune cells. Leptin, the adipoc...

Females of the South American plains vizcacha, Lagostomus maximus, show peculiar reproductive features such as massive polyovulation up to 800 oocytes per estrous cycle and an ovulatory process around mid-gestation arisi...

Objective: Periodontally accelerated osteogenic orthodontics (PAOO) combines selective alveolar decortication with orthodontic force to accelerate tooth movement, but its influence on the gingival crevicular fluid (GCF) ...

Smilax glabra, a perennial vine with high pharmaceutical value, exhibits seed dormancy under natural conditions that severely restricts artificial propagation and industrial-scale cultivation. This study aims to systemat...

Our understanding of the synthesis and remodeling of mitochondrial phospholipids remains incomplete. Two isoforms of glycerol-3-phosphate acyltransferase (GPAT1 and 2) and two isoforms of acylglycerol-3-phosphate acyltra...

Abstract Fungal inositol phosphorylceramide (IPC) synthase is an essential enzyme complex that catalyzes a critical step in sphingolipid biosynthesis. It is the molecular target of potent antifungal aureobasidin A (AbA)....

BackgroundEndometriosis is a complex gynaecological disorder that affects 10%–15% of reproductive-age women and is characterized by chronic inflammation, pelvic pain, and infertility. Although mitochondrial dysfunction...

Coffee is a remarkable source of bioactive compounds, including anthocyanins, proanthocyanidins, and carotenoids, with health benefits. To fully understand the biochemical and molecular regulation mechanisms behind Coffe...

High-yielding sorghum-sudangrass hybrids with reduced lignin content, obtained using the “brown-midrib gene 6” gene technology, are recommended and successfully used for silage, but their sanitary-relevant features a...

Survival of transplant recipients strongly depends on the success of the immunosuppressive regimen. Many immunosuppressive drugs such as calcineurin inhibitors (CNIs) and purine biosynthesis inhibitors (mycophenolic acid...

The oleaginous unicellular microalga Haematococcus pluvialis is being intensely studied as a source of carotenoids and lipids with potential biotechnological and biomedical applications. The aim of this study was to anal...

Coenzyme A (CoA) is a vital cofactor involved in energy metabolism, lipid biosynthesis, protein modification, and epigenetic regulation. Disruptions in CoA biosynthesis have been implicated in neurometabolic disorders su...

Abstract Perinatal failure in the growth hormone (GH)-insulin-like growth factor-1 (IGF-1) axis causes impaired body growth and central and autonomous neurodevelopmental disorders. However, whether a primary neurodevelop...

Abstract This study reports the green biosynthesis of bioactive selenium nanoparticles using Catharanthus roseus extract as a reducing and stabilizing agent. Liquid chromatography–electrospray ionization tandem mass sp...

Abstract Growing evidence indicates a crucial role of the gut microbiota in physiological functions. Gut-brain axis imbalance has also been associated with neuropsychiatric and neurodegenerative disorders. Studies have s...

Abstract Selenium (Se) enriched forest-grown ginseng is famous for its high Se content and excellent protein quality, which are necessary for varieties of metabolic processes and play an important role in both ginseng gr...

Atherosclerosis, driven by elevated cholesterol levels, remains a major risk factor for cardiovascular disease. 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), the rate-limiting enzyme involved in cholesterol bio...

Reclaimed backfill solution, a process-derived liquid generated during pedunculated filament treatment in tobacco manufacturing, has potential value for resource recovery and process reuse; however, its storage stability...

Abstract Fungal histone methylation modification (HMM) includes methylation and demethylation at the histone lysine/arginine residues, which are catalyzed by the methyltransferases (HMTs) and demethylases (HDMs) of histo...

Ergot alkaloids are a type of alkaloids secondary metabolic produced by Claviceps or Epichloë spp infected with black barley， wheat， rye， rice， corn， oats， and various other gramineous plants. Long-term expo...

Flavonoids are polyphenolic compounds and color most flowers, fruits and seeds. The regulation of flavonoid biosynthetic genes is directed by ternary complexes composed of MYB-bHLH-WD40 transcription factors. DNA-binding...