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Qué reúne NODOVOX Discovery: catálogos institucionales, recursos electrónicos, revistas de acceso abierto, colecciones disponibles y enlaces de consulta académica.

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120 resultados encontrados.

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In vitro evaluation of gamma irradiation versus autoclaving on the morphology and regenerative potential of Allo-demineralized dentin matrix
Artículo
Material complementario disponible Artículo DOAJ
Marwa Ahmed Abozed et al · BMC · 2026 · ISSN 1472-6831
Abstract Background Demineralized dentin matrix (DDM) can serve as a novel scaffold for dental tissue regeneration. This study aimed to assess the impact of two distinct sterilizing methods on morphology of Allo-DDM as w...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
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Investigate the heterogeneity of colorectal cancer patients at the single-cell level prior to and subsequent to immunotherapy
Artículo
Acceso abierto Artículo DOAJ
Heng Zhao et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
BackgroundImmune checkpoint blockade (ICB) has improved outcomes for a subset of colorectal cancer (CRC) patients, yet the cellular determinants that drive heterogeneous treatment responses remain insufficiently understo...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Open Access
Offense-defense in bone infection: interferon regulation and the immune evasion of Staphylococcus aureus
Artículo
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Jinrong Qian et al · Frontiers Media S.A · 2026 · ISSN 2813-6144
Bone infection is a severe disease caused by microbial invasion of bone tissue, characterized by inflammatory responses, bone destruction, and impaired repair. Its high recurrence rate and refractory nature have posed si...
LCC TENDOk1pY3JvYmlvbG9neQ~~Idioma eng
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Parenteral neonatal priming followed by heterologous mucosal booster favors IgM+ memory B cell induction over systemic plasma cell differentiation
Artículo
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Poorya Foroutan Pajoohian et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Early-life vaccinations often yield short-lived antibody (Ab) responses due to limited germinal center (GC) reaction and plasma cell (PC) survival. The aim of the study was to assess how vaccine delivery routes (homologo...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Open Access
Perubahan morfologi sel HeLa setelah paparan ekstrak etanolik Curcuma longa
Artículo
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Suryani Hutomo et al · faculty of dentistry universitas gadjah mada · 2017 · ISSN 2460-0164
Cell morphological changes on HeLa cells after Curcuma longa etanolik extract exposure. Curcuma is mostly found in the areas with tropical and sub-tropical climate, and is one of original plants of Southeast Asia. In Ind...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
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Open Access
Thyroid hormone action on innate immunity
Artículo
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Montesinos, Maria del Mar et al · Frontiers Media S.A · 2019 · ISSN 1664-2392
The interplay between thyroid hormone action and the immune system has been established in physiological and pathological settings. However, their connection is complex and still not completely understood. The thyroid ho...
Idioma eng
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Open Access
Trypanosoma cruzi Induces Regulatory B Cell Alterations in Patients With Chronic Chagas Disease
Artículo
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Girard, Magalí Celeste et al · Frontiers Media · 2021 · ISSN 2235-2988
The clinical evolution of patients with chronic Chagas disease (CCD) is mainly associated with an excessive inflammation and a defective immunomodulatory profile caused by the interaction between T. cruzi and the host. R...
Idioma eng
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Open Access
Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4
Artículo
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Cooke, Mariana et al · American Society for Biochemistry and Molecular Biology · 2011 · ISSN 1936-1948
Acyl-CoA synthetase 4 (ACSL4) is implicated in fatty acid metabolism with marked preference for arachidonic acid (AA). ACSL4 plays crucial roles in physiological functions such as steroid synthesis and in pathological pr...
Idioma eng
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Open Access
A First-in-Human Base Edit Gene Therapy for CD40L Deficiency X-Linked Hyper IgM (XHIGM) Syndrome
Artículo
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Suk See De Ravin et al · Rockefeller University Press · 2026 · ISSN 3065-8993
CD40L-deficient X-linked hyper IgM (XHIGM) syndrome is characterized by defective B cell class switching, deficiency of immunoglobulins G, A, and E, plus other immune abnormalities due to disrupted CD40L–CD40 interacti...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Aluminum suppresses humoral immunity through counteracting oxidative stress and repair effects of iron supplementation
Artículo
Material complementario disponible Artículo DOAJ
Yihuai LIANG et al · Editorial Committee of Journal of Environmental and Occupational Medicine · 2026 · ISSN 2095-9982
BackgroundAluminum (Al) is a lightweight metal that is widely present in the environment and the human body. It has been documented to cause various adverse health effects including the suppression of humoral immunity.Ob...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; TENDOlRveGljb2xvZ3kuIFBvaXNvbnM~Idioma eng
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Anticancer potential of Curcuma caesia: induction of DNA damage and apoptosis in cervical cancer
Artículo
Acceso abierto Artículo DOAJ
Megha Radhakrishnan et al · BMC · 2026 · ISSN 2662-7671
Abstract Background Cervical cancer remains the fourth most common malignancy among women worldwide, with limited therapeutic success in advanced and recurrent stages. Conventional treatments, including radiotherapy and ...
LCC TENDOk90aGVyIHN5c3RlbXMgb2YgbWVkaWNpbmU~Idioma eng
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Open Access
CS2164 combined with radiation suppressed tumor growth via γ-H2AX persistence and ROS accumulation
Artículo
Acceso abierto Artículo DOAJ
Shun-li Peng et al · BMC · 2026 · ISSN 1471-2407
Abstract Background CS2164 is an oral multi-target inhibitor that targets angiogenesis-related kinases, mitosis-related kinases, and chronic inflammation-related kinases. However, the added clinical benefit of CS2164 com...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Chemerin Promotes Oral Squamous Cell Carcinoma Progression via NLRP3-Mediated Pyroptosis and the GSDMD-N Pathway
Artículo
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Xuan Zhang et al · Elsevier · 2026 · ISSN 0020-6539
ABSTRACT: Introduction and aims: Oral squamous cell carcinoma (OSCC) is a common malignant tumour of the head and neck region. In recent years, the relationship between pyroptosis and tumours has received increasing att...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
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Open Access
CircSPARC mediates an immunosuppressive tumor microenvironment by regulating the miR-199a-5p/LASP1 axis in non-small cell lung cancer
Artículo
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Chengsheng zhang et al · BMC · 2026 · ISSN 1471-2466
Abstract Non-small cell lung cancer (NSCLC) is a major cause of cancer-related mortality globally, linked to an immunosuppressive microenvironment. Circular RNA circSPARC is crucial in cancer, but its function in NSCLC r...
LCC TENDOkRpc2Vhc2VzIG9mIHRoZSByZXNwaXJhdG9yeSBzeXN0ZW0~Idioma eng
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Combined B Cell Aplasia and Hypereosinophilia as a Complication of Lamotrigine Therapy
Artículo
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Katherine Michaelis et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundAlthough drug rash with eosinophilia and systemic symptoms (DRESS) and anticonvulsant hypersensitivity syndrome are well-known complications of anti-seizure medications (ASMs), lesser-known immunologic complica...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Correlation of Activated-Inflammatory T Cell Subtypes in Patients Tested for Lymphocyte Immunodeficiency
Artículo
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Charles Lutz · Rockefeller University Press · 2026 · ISSN 3065-8993
CD19negCD20dim T cells are mostly CD8+ and predominantly express memory markers. Based on the literature, they may be a subset of inflammatory T cells rather than a transient activated state. I postulated that CD19negCD2...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Institucional
Cross-talk between microglia and neurons regulates HIV latency.
Artículo
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David Alvarez-Carbonell et al · Public Library of Science (PLoS) · 2019 · ISSN 1553-7366
Despite effective antiretroviral therapy (ART), HIV-associated neurocognitive disorders (HAND) are found in nearly one-third of patients. Using a cellular co-culture system including neurons and human microglia infected ...
LCC LCC:Immunologic diseases. Allergy; LCC:Biology (General)Idioma eng
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Determinants of Fate Progression Beyond the Human Tfh Cell Stage
Artículo
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Suzanna Rachimi et al · Rockefeller University Press · 2026 · ISSN 3065-8993
T follicular helper (Tfh) cells have been reported to have multiple trajectories, including terminally differentiated Tfh, memory-like circulatory Tfh (cTfh), and, most recently, induced T follicular regulatory (iTfr) ce...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Open Access
Effects on Goat Meat Extracts on α-Glucosidase Inhibitory Activity, Expression of Bcl-2-Associated X (BAX), p53, and p21 in Cell Line and Expression of Atrogin-1, Muscle Atrophy F-Box (MAFbx), Muscle RING-Finger Protein-1 (MuRF-1), and Myosin Heavy Chain-7 (MYH-7) in C2C12 Myoblsts
Artículo
Acceso abierto Artículo DOAJ
Joohyun Kang et al · Springer Nature · 2023 · ISSN 2636-0772
Abstract This study examined the α-glucosidase inhibitory, and apoptosis- and anti-muscular-related factors of goat meat extracts from forelegs, hind legs, loin, and ribs. The goat meat extracts were evaluated for their...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Animal cultureIdioma eng
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Elucidating the Pathogenesis of Chronic Norovirus in Inborn Errors of Immunity: Lessons from Single-Cell Transcriptomics of Biopsies and Patient-Derived Organoids
Artículo
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Jessica Durkee-Shock et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Chronic norovirus infection (CNI) causes significant morbidity and mortality in immunocompromised patients, including those with inborn errors of immunity (IEI). Gastrointestinal samples from patients with CNI demonstrat...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Enhancing Pediatric Cancer Survival in Indonesia: The Role of CAR T Cell Therapy
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Muhammad Al Azhar et al · Dharmais Cancer Hospital - National Cancer Center · 2024 · ISSN 1978-3744
Pediatric cancer poses a major health challenge globally, especially in low-middle-income countries like Indonesia. The survival rate of pediatric cancer in many high-income countries (HICs) reaches 90%, while it only ra...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Exosome-mediated delivery of miRNA-1290 inhibitor enhances JNK-dependent tissue-resident memory T cell immunity in prostate cancer
Artículo
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Bin Liang et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Prostate cancer (PCa) is a leading malignancy in men, particularly challenging in its advanced stages due to treatment resistance and immune evasion. MicroRNA-1290 (miR-1290) was identified to be implicated in t...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection
Artículo
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Ortiz Wilczyñski, Juan Manuel et al · Public Library of Science · 2020 · ISSN 1553-7366
Multiple sclerosis (MS) is a highly disabling neurodegenerative autoimmune condition in which an unbalanced immune response plays a critical role. Although the mechanisms remain poorly defined, helminth infections are kn...
Idioma eng
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Geranylgeraniol Modulates Inflammatory and Metabolic Pathways but Not IgD Biology in Mevalonate Kinase Deficiency
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Anna Sediva et al · Rockefeller University Press · 2026 · ISSN 3065-8993
ObjectivesMevalonate kinase deficiency (MKD) is a metabolic disorder caused by a block in the mevalonate pathway, leading to impaired synthesis of cholesterol and isoprenoids. Clinically, MKD presents with recurrent infl...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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