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Abstract Background Chronic hepatopathies present a diagnostic challenge, with different diseases being associated with similar clinical and laboratory findings. Characterization of dogs with chronic hepatopathies can be...

BackgroundDepressive symptoms are common in gastroenterology practice but often missed due to patient stigma and the limitations of self-report questionnaires. This detection gap limits patient access to necessary mental...

The goal of the medical specialty of geriatrics is to treat the complicated needs of elderly patients while highlighting the need of preserving functional independence in the face of chronic illnesses. A unique and compr...

Study objective: To evaluate whether impaired ventriculo-aretrial interaction characterizes chronic ischemic heart disease (CIHD) caused by stable chronic obstructive coronary artery disease (CAD), using wave intensity a...

Objective: Anemia is one of the most important factors that decrease the quality of life in patients with end-stage renal desease receiving hemodialysis treatment. In these patients, Erythropoietin stimulating agents (E...

Abstract Background Mongolia has a high prevalence of liver disease from chronic viral hepatitis infections, which can compromise the immune response. It is unclear whether people with chronic liver disease produce a rob...

Chronic limb disuse during the active growth phase can induce complex secondary deformities, including paradoxical bone overgrowth. A 12-month-old neutered male Toy Poodle presented with non-weight-bearing right forelimb...

Abstract Background In pediatric chronic extrahepatic portal vein obstruction (EHPVO), contrast-enhanced computed tomography (CECT) may provide suboptimal visualization of intrahepatic portal vein (PV) branches and may t...

Background: In multiple sclerosis (MS), chronic “smoldering” lesions are driven by microglial activation, which promotes demyelination and disease progression. However, microglia exhibit a functional dichotomy by per...

Introduction One in five people experience chronic pain globally, yet management remains suboptimal and discrepant guideline recommendations are common. To increase pain literacy and improve concordance between evidence ...

Previous studies have suggested that macrophages may contribute to acute Leptospira dissemination, as well as having a major role in kidney fibrosis. Our aim was to characterize the role of macrophages and galectin 3 (Ga...

Abstract Neutrophil-driven inflammation is central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Emerging evidence suggests that Ca²⁺ signaling is critical in regulating neutrophil activation, r...

Chronic inflammation is a hallmark of many diseases, including persistent viral infections. In human immunodeficiency virus (HIV) infection, sustained immune activation contributes to end-organ damage and non-AIDS comorb...

Background: Chronic lymphedema is a common late effect after completion of head and neck cancer (HNC) treatment, contributing to substantial symptom burden and negatively impacting quality of life. No effective approache...

Abstract Background Dogs with hepatocutaneous syndrome (HCS) have marked plasma hypoaminoacidemia, but its occurrence in dogs with chronic liver diseases not associated with HCS (non‐HCS CLD) is unknown. Objectives To ...

Background Presently, approaches for the early treatment of pathological anxiety in patients with chronic non-communicable diseases are lacking, thus delaying the initiation of symptom management at the early onset of th...

Chronic dialysis hypotension is described as low systolic blood pressure (

ABSTRACT Background Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved in the pathogenesis. Hypothesis/Objectives To evaluate the efficacy of a single enema feca...

Background Social relationships are associated with mortality and chronic conditions. However, little is known about the effects of social relationship satisfaction on multiple chronic conditions (multimorbidity).Aims To...

One of the factors responsible for suppression of cellular and humoral immune system is essential aminoacid (EAA) deficiency in the patients with end-stage renal disease (ESRD) . It has been reported that the functions o...

Renal amyloid A (AA) amyloidosis is one of the systemic etiologies of nephrotic syndrome (NS) in adults. Chronic inflammatory conditions including rheumatoid arthritis, familial periodic fever syndromes, spondyloarthropa...

Abstract Background Microglial activation is increasingly recognized as a critical contributor to both the initiation and chronification of migraine. Recent advances have highlighted the importance of receptor-mediated s...

Background and Aim: Brucellosis is a chronic infectious disease of cattle that may influence not only animal health but also the nutritional and sanitary quality of meat. While veterinary–sanitary implications of infec...

In this paper, we demonstrate that circulating antibodies from chronic periodontitis patients reacting with atrial β1-adrenoceptors (β1-ARs) act as an inducer of soluble CD40 ligand (sCD40L) release and prostaglandin E...