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Abstract Background Detection of free light chains (fLC) in animals relies on protein electrophoresis or the Bence‐Jones protein test on urine. Objective To describe the detection of both serum fLC (sfLC) and urine fLC...

Meta-optics have opened new possibilities for portable, high-performance microscopy, offering ultrathin and highly customizable wavefront control in scenarios where bulky optics limit adoption. Here, we use this capabili...

BackgroundEndometriosis is a complex gynaecological disorder that affects 10%–15% of reproductive-age women and is characterized by chronic inflammation, pelvic pain, and infertility. Although mitochondrial dysfunction...

Abstract Alzheimer’s disease (AD) is a prevalent and progressive neurodegenerative disease characterized by behavioral abnormalities, memory loss, and cognitive decline, presenting significant challenges for early diag...

Abstract Optical fiber sensing carries a number of potential advantages for diagnostics and biomarker detection and monitoring, yet particular challenges persist in linking molecular recognition events to a change in the...

In this article, we present a review of the published and non-published information about the evidence of figurative art ascribed to the Early Formative Period (1500-1000 b. C.) in the North and North-Central Coast of th...

ABSTRACT Background and Aims Sepsis remains a leading cause of morbidity and mortality worldwide, particularly in low‐ and middle‐income countries where diagnostic delays are common. The complete blood count (CBC) is...

Abstract Background Amid growing demands, workforce shortages, and rising costs, the evolving role of diagnostics—driven by technological innovation—underscores the urgent need to rethink the diagnostic process with ...

Abstract Background The global rise of multidrug-resistant Enterobacterales, particularly extended-spectrum beta-lactamase (ESBL)- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae, poses a critical ...

Abstract Prostate cancer (PCa) is one of the most common malignancies in men worldwide, yet early detection and accurate risk stratification remain challenging. MicroRNAs (miRNAs), key post-transcriptional regulators, ha...

Lichen planus (LP) is a chronic, inflammatory dermatosis characterized by presence of polygonal, flat-raised, purple-red papules and intense itching [1]. Incidence of the disease is estimated at 0.1–1.0%. Apart from t...

Abstract Case Description We describe a case of presumptive acquired systemic lupus erythematosus secondary to phenobarbital administration in a dog, which resolved with withdrawal of the drug. Clinical Findings A 3.5 ...

Abstract Background Quantitative structure-activity relationship (QSAR) models are central to computer-aided drug discovery and predictive toxicology, but practical adoption is often impeded by ad-hoc tooling, inconsiste...

Abstract Background Tuberculosis remains a major public health challenge in Somalia, where a fragile health system and reliance on private providers complicate care. Although Public-Private Partnerships are globally reco...

Abstract Introduction Quantitative bias analysis (QBA) methods have been developed, with growing applications to epidemiological studies. Bayesian QBA (BQBA) methods may be superior in effectively using evidence-based pr...

Oblique plane microscopy (OPM) directly captures object information in a plane tilted from the focal plane of the objective lens without the need for slow z-stack acquisition. This unconventional widefield imaging approa...

Extracellular vesicles (EVs) are complex biological nanoparticles endogenously secreted by all eukaryotic cells. EVs carry a specific molecular cargo of proteins, lipids, and nucleic acids derived from cells of origin an...

Abstract Background Identification of risk and protective factors for canine visceral leishmaniasis (CVL) is essential to understand the epidemiology of the disease and direct prevention and control strategies. Building ...

Saliva as a microfluidic system offers numerous advantages for both general and oral health diagnostic and therapeutic procedures since its assembly is quick, stress-free, inexpensive and non-invasive. Moreover, saliva i...

Abstract Background There is no standardized methodology to measure antibiotic drug use (AU) in small animal veterinary hospitals. Objectives To estimate AU prevalence in a small animal veterinary teaching hospital and c...

Abstract Background Infections caused by members of the Mycobacterium fortuitum complex are generally mild and confined to skin and soft tissues, while severe disease in immunocompetent individuals is uncommon. Within th...

Dermatomyositis (DM) is one of the so-called idiopathic inflammatory myopathies (IIM). Dermatomyositis is an autoimmune disorder characterized by the presence of cutaneous lesions and/or symptoms of muscle involvement wi...

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disease characterized by heterogeneous symptom patterns. Previous work suggested that specific symptoms tend t...

Syphilis (lues) is a systemic bacterial disease transmitted mainly by sexual contacts and caused by Treponema pallidum subsp. pallidum . Due to its numerous symptoms, including various cutaneous and mucosal manifestat...