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Xue Fu,1 Jiawei Dong,2 Jian Yang,2 Xiaotian Zhang,2 Shangkun Cai,2 Yiwei Zhang,2 Shenglong Lv,2 Meng Zhang2 1Department of Emergency, Hebei Medical University Third Hospital, Shijiazhuang, 050051, People’s Republic of ...

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by aberrant immune responses and tissue remodeling. Ligustrazine has multiple effects, such as enh...

Background: Barrett's esophagus (BE) represents a critical precancerous lesion arising from chronic gastroesophageal reflux disease (GERD), with significant risk of progression to esophageal adenocarcinoma. Despite advan...

This Campbell systematic review examines the empirical research on the effectiveness of female genital mutilation/cutting (‘FGM/C’) interventions to reduce the occurrence of FGM/C practices in the 28 African countrie...

This Campbell systematic review assesses the effects of psychosocial interventions for school refusal. The review summarizes the findings from eight studies. Medium quality evidence shows that cognitive‐behavioural the...

Research aim. The aim of the study is to analyze the publishing activities of Ivan Lypa in Odesa, particularly the role of the publishing house Odeska Literaturna Spilka ("O. L. S.") [Odesa Literary Union], its contrib...

This Campbell systematic review examines the impact of reducing the maximum duration of unemployment benefits on job‐finding rates. Seven studies were included in the review, all of which are from European countries. I...

BackgroundIt is well established that tumor-associated macrophages (TAMs) are crucial to the development of tumors. Here, we looked into how SHP2 and M2/M1 macrophages affected gastric cancer.MethodsBulk RNA-seq analysis...

Accurate RNA quantification at the single-cell level is critical for understanding the dynamics of gene expression and regulation across space and time. Single molecule FISH (smFISH), such as RNAscope, provides spatial a...

This Campbell systematic review assesses the effectiveness of school‐based decision‐making. The review summarises findings from 17 impact studies and nine studies of barriers and enablers. School‐based decision‐m...

Abstract Background Class size reductions in general education are some of the most researched educational interventions in social science, yet researchers have not reached any final conclusions regarding their effects. ...

Abstract Background Agroforestry, the intentional integration of trees or other woody perennials with crops or livestock in production systems, is being widely promoted as a conservation and development tool to help meet...

BackgroundDiffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin lymphoma, exhibits genetic heterogeneity and variable treatment responses. Discovering new therapeutic targets is critical to improve outcomes....

Background The incidence of paediatric cancers has increased in recent years; however, with advances in the treatment of paediatric cancer, almost 80% of children and adolescents who receive a diagnosis of cancer become ...

Although genomewide RNA expression analysis has become a routine tool in biomedical research, extracting biological insight from such information remains a major challenge. Here, we describe a powerful analytical method ...

UNLABELLED: The two main functions of bioinformatics are the organization and analysis of biological data using computational resources. Geneious Basic has been designed to be an easy-to-use and flexible desktop software...

We present here a framework for the study of molecular variation within a single species. Information on DNA haplotype divergence is incorporated into an analysis of variance format, derived from a matrix of squared-dist...

BACKGROUND: Gene set enrichment (GSE) analysis is a popular framework for condensing information from gene expression profiles into a pathway or signature summary. The strengths of this approach over single gene analysis...

With its theoretical basis firmly established in molecular evolutionary and population genetics, the comparative DNA and protein sequence analysis plays a central role in reconstructing the evolutionary histories of spec...

Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr. Enrichr currently contains a l...

SUMMARY: GenAlEx: Genetic Analysis in Excel is a cross-platform package for population genetic analyses that runs within Microsoft Excel. GenAlEx offers analysis of diploid codominant, haploid and binary genetic loci and...

A method of ‘‘natural population analysis’’ has been developed to calculate atomic charges and orbital populations of molecular wave functions in general atomic orbital basis sets. The natural analysis is an alte...

Microarrays can measure the expression of thousands of genes to identify changes in expression between different biological states. Methods are needed to determine the significance of these changes while accounting for t...

BACKGROUND: Correlation networks are increasingly being used in bioinformatics applications. For example, weighted gene co-expression network analysis is a systems biology method for describing the correlation patterns a...