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Abstract Background After resection surgery, recurrence occurs in more than 30% of colorectal cancer (CRC) patients. Previous studies have highlighted the role of the gut microbiota in CRC initiation and progression; how...

ABSTRACT Tannins represent one of the most abundant polyphenolic compounds in plants. Tannins exist as a multitude of chemically unique entities in nature. The most commonly occurring tannins are typically divided into t...

Abstract The development of safe and effective radioprotective agents with minimal side effects, particularly for high‐dose exposure, remains a global priority. E0703, a novel steroidal compound structurally derived fr...

In toxicity and pharmacological studies C. elegans are exposed to different compounds and the effects analyzed by observing worm viability or behavior. An alternative approach is to use locomotor activity as a readout, w...

BackgroundStreptococcus canis is an emerging zoonotic pathogen capable of causing infective endocarditis (IE) in animals and humans. In IE, bacterial biofilms form vegetations on heart valves, protecting microbes from a...

Harnessing root-associated microbiomes to promote beneficial microbial compositions could offer a sustainable strategy to increase crop resilience. Major challenges impeding this strategy are the lack of understanding of...

We report that a novel Arabidopsis thaliana kinase cascade shows telltale similarities to the kinase cascades of oxidative stress response kinases (OSRKs) from humans and animals. A previously uncharacterized A. thaliana...

Plasmodiophora brassicae, the obligate parasite responsible for clubroot in Brassica crops and other crucifers, poses a major challenge to sustainable disease management due to its biotrophic lifestyle and adaptability. ...

Plant nucleotide-binding leucine-rich repeat receptors (NLRs) function in both shoots and roots as key components of plant immunity, yet their biological roles in roots remain poorly understood. Here, we established a co...

Nipah virus (NiV) is an emergent paramyxovirus that causes serious disease in humans and animals. Accurate quantification of neutralizing antibodies (nAB) against NiV is essential for vaccine development. The current sta...

The Developmental Origins of Health and Disease theory describes early life as a critical window for long-term metabolic health. Accumulating evidence has identified the gut microbiota as a key mediator of early-life met...

Tuberculosis (TB) is one of the most prevalent infectious diseases worldwide. However, few molecules related to bacterial killing within T cell-induced macrophages are known; therefore, elucidating host responses against...

Lassa fever is a zoonotic disease endemic to several West African countries, with seasonal outbreaks and potential to cause future epidemics. Vaccines and other medical countermeasures are in development, requiring relia...

The gut microbiota plays a central role in modulating both immunity and metabolism. Obesity-associated microbiota configuration is a critical driver of persistent inflammatory activation and immune dysfunction, ultimatel...

Soybean cyst nematode (SCN, Heterodera glycines Ichinohe) is the most economically damaging soilborne pathogen affecting soybean, causing significant yield losses in the United States and worldwide. Current commercial cu...

Background & aims Proton pump inhibitor (PPI) use has been associated with metabolic dysfunction associated with steatotic liver disease (MASLD) in multiple studies. While the association is confounded by various risk fa...

Materias / palabras clave: Hepatitis B; functional cure; anti-HBs; Peg-IFNα; vaccination

Microbial siderophores are low-molecular-weight compounds with a strong affinity for ferric (FSe3+) ions. They play a pivotal role in plant-microbial interactions by enhancing iron bioavailability to plants, primarily th...

Mitochondria are vital for maintaining cellular homeostasis. However, mitochondrial damage is evident in patients with chronic hepatitis B (CHB). The role of mitochondrial dysfunction in the persistence of viral replicat...

Mixed infection refers to the presence of multiple Mycobacterium tuberculosis strains within one host, while heteroresistance denotes the coexistence of drug-susceptible and drug-resistant strains or genotypes. Mixed inf...

The soybean cyst nematode (SCN), Heterodera glycines, remains the most damaging pathogen of soybean worldwide. Genomic advances over the past two decades have transformed our understanding of both the nematode and its ho...

The nitrogen-fixing symbiosis between leguminous plants and soil bacteria, collectively termed rhizobia, is a major contributor of fixed nitrogen to the biosphere. The ability of legumes to secure nitrogen from the atmos...

Recent studies have shown that the presence of an RNA modification, N6-methyladenosine (m6A), in viral RNAs during infection significantly impacts the outcome of viral replication and pathogenesis. In particular, various...

The composition of the plant microbiome is shaped not only by the host plant and abiotic environmental factors, but also by intermicrobial cooperation and competition. Plant pathogens, therefore, must remain competitive ...