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IntroductionAvian pathogenic Escherichia coli (APEC) infection poses a serious threat to the poultry industry and is increasingly difficult to control because of antimicrobial resistance.MethodsThis study combined microb...

Abstract Objective This study aimed to elucidate the molecular mechanisms by which Apigenin (APG) reverses MET-TKI resistance in non-small cell lung cancer (NSCLC). Methods Network pharmacology and molecular docking were...

The current study provides a comprehensive look of the adsorption process of Candida rugosa lipase (CRL) on Ca2Fe2O5 iron oxide nanoparticles (NPs). Protein-support interactions were identified across a broad range of pH...

Alcoholic gastric ulcer is a clinically prevalent gastrointestinal disorder whose pathogenesis is closely associated with both the direct mucosal damage induced by ethanol and the subsequent inflammatory response. Isoliq...

Jie Wei,1,* Guan Ye Nai,2,3,* GuoWu Lin,4,* Yu Mei Huang,1 Wei Jie Zhou,4 Rong rong Liu1 1Departments of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ...

Abstract Objective Myelodysplastic syndromes (MDS) are associated with a high risk of progression to leukemia, highlighting the critical need to explore novel therapeutic agents. Based on network pharmacology predicti...

Objective: Diabetic retinopathy (DR) is a major microvascular complication of diabetes. This study aimed to elucidate the protective effects of curcumin, a bioactive dietary compound derived from turmeric, and its underl...

Colorectal cancer is the second leading cause of death among all cancer cases worldwide. Cancer cells often exhibit overexpression of cyclooxygenase-2 (COX-2), producing prostaglandin E2 (PEG2) and subsequent inflammatio...

Chitooligosaccharides (COS) and fully N-acetylated chitooligosaccharides (NACOS) differ in degree of acetylation (DA), yet their anti-inflammatory activities remain unclear. This study evaluated COS and NACOS with define...

Abstract Background Naringenin has shown attractive neuroprotective effects; however, it is characterized by low oral bioavailability. Naringenin-loaded nanoparticles (Nar-NPs) were prepared for enhanced delivery, and ...

Pothos scandens, belonging to the Araceae family, locally known as “batilata,” is traditionally used for treating various chronic diseases in folk medicine, such as epilepsy, seizures, convulsions, wounds, snakebites...

BackgroundStage F3 liver fibrosis represents a critical phase for intercepting the progression toward irreversible cirrhosis. Despite its clinical significance, effective interventions remain scarce. Clinical observation...

Objective: To investigate whether herbal pair Rheum palmatum L. (R. palmatum; Da Huang)–Prunus persica (L.) Batsch (P. persica; Tao Ren) (RP) can restore endometrial receptivity and mitigate adenomyosis (AM)-associated...

Pseudomonas aeruginosa is a highly pathogenic Gram-negative microorganism associated with high mortality levels in burned or immunosuppressed patients or individuals affected by cystic fibrosis. Studies support a coloniz...

Abstract Recently, interest in food-derived bioactive peptides as promising ingredients for the prevention and improvement of hypertension is increasing. The purpose of this study was to determine the structure and antih...

The Mapuche and their ancestors have used D. winteri in traditional medicine. In the present study, the essential oil extract of D. winteri leaves (DW_EO) were characterized chemically and biologically to evaluate its ph...

BackgroundSeptic cardiomyopathy (SCM) is one of the most common and serious complications of sepsis. Earlier research has identified reciprocal regulation between SCM and gut microbiota (GM), but the mechanistic basis of...

Abstract Background 20-Hydroxyecdysone (20E), a natural polyhydroxylated steroid found in various edible plants, exhibits diverse pharmacological effects. Pulmonary arterial hypertension (PAH) remains challenging to trea...

Background Tranexamic acid (TXA) is widely used for pigmentary disorders, but its anti-ageing potential remains unclear. This study aimed to evaluate whether topical 3% TXA improves early periorbital wrinkles in women wi...

In this project, our research group has performed an interesting work in which interactions of acarbose (ACB) with normal human serum albumin (HSA) and glycated HSA (GHSA) have been investigated by chemometrics assisted-...

Abstract Background Lichens produce several secondary metabolites with significant biological and pharmacological activities, among which usnic acid (UA) is particularly notable. This study aimed to investigate the cytot...

Abstract Simultaneous inhibition of DNA gyrase and topoisomerase IV (Topo IV) is a primary pharmacological strategy to enhance antibacterial efficacy and markedly reduce the emergence of antibiotic resistance. In this re...

Abstract Background Hyperosmotic shock and the resulting cell volume compression are commonly experienced by organs such as the kidneys, causing rapid formation of hyperosmotic phase separation (HOPS) condensates in the ...

Abstract Elevated levels of the gut-derived metabolite trimethylamine N-oxide (TMAO) are associated with atherosclerosis and thrombotic disorders, yet the molecular basis of its contribution to these pathologies remains ...