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BackgroundRenal cell carcinoma (RCC) is the most common kidney cancer in adults. The advent of immune checkpoint inhibitors (ICIs), particularly in combination with tyrosine kinase inhibitors (TKIs), has significantly im...

In recent years， quantitative microbial risk assessment （QMRA） for food safety has developed rapidly both domestically and internationally. QMRA integrates multidisciplinary theoretical knowledge and technical meth...

The aim of this study was to clarify the current situation and challenges of community-based rehabilitation (CBR) in depopulated areas from the perspective of physicians and to develop a model suited to such contexts. Se...

Background. Deciding whether to participate in a radiotherapy trial is complex for patients with head and neck cancer. Standard patient information leaflets meet ethical requirements but do not provide balanced compariso...

BackgroundComplex congenital heart disease (CHD) has long been a significant cause of infant mortality and severe morbidity. However, pediatric cardiac rehabilitation (CR) is gaining recognition, and evidence regarding p...

Abstract Background Acetabular fractures, predominantly caused by high-energy trauma, pose a substantial healthcare burden in low- and middle-income countries (LMICs) such as Nepal. This study aimed to characterize the e...

Background Clinical brain–computer interface (BCI) for mental disorders is an emerging interdisciplinary research field, posing new ethical concerns and challenges, yet lacking practical ethical governance guidelines f...

IntroductionWellness encompasses multiple dimensions that vary across populations, particularly among Saudi women, whose experiences are shaped by cultural, social, and religious factors. These factors shape the way well...

Human–wildlife relations in alpine ecosystems reflect the combined effects of climate change, land-use transitions, and governance capacity. Rather than focusing solely on local conflict dynamics, this study investigat...

Despite decades of global attention, work-related musculoskeletal disorders (MSD) remain a significant challenge, with substantial personal and societal costs (1). The lack of progress in addressing this prevalent proble...

Abstract Left atrial appendage (LAA) aneurysm is a rare structural abnormality that can predispose to significant complications, including systemic embolism and complex supraventricular arrhythmias. Here, we report a 44-...

ObjectiveTo investigate the effectiveness of rhythmic music game–based intervention in improving executive functions and sensorimotor abilities among children with Attention-Deficit/Hyperactivity Disorder (ADHD), there...

Abstract The medical humanities are an interdisciplinary field that combines the humanities, social sciences, and arts with medical education and practice. It fosters a multidisciplinary understanding of the human condit...

Background. Long QT Syndrome (LQTS) is a hereditary cardiac channelopathy that predisposes individuals to malignant arrhythmias and sudden cardiac death. In athletes, physiological cardiac adaptations can mask or mimic L...

Abstract Objective To assess how lower lip inclination and chin prominence interact to influence facial profile aesthetics and to establish evidence-based angular criteria for orthognathic treatment planning. Methods Thi...

Abstract Background Medication management at hospital discharge is particularly complex for older patients with multimorbidity, with additional communication challenges arising from both patient and healthcare-related fa...

Abstract Hypohidrotic ectodermal dysplasia (HED), caused by mutations in genes such as EDAR, is a genetic disorder characterized by hypodontia, hypotrichosis, and hypohidrosis. Dental anomalies in HED patients lead to fu...

Uninsured populations face disproportionately high rates of unplanned pregnancy due to financial and structural barriers to effective contraception. While long-acting reversible contraception (LARC), such as intrauterine...

IntroductionEpidermolysis bullosa (EB) is a rare genetic disease with skin and mucosal fragility. Severe cases present major physical and psychological compromise, contributing to comorbidities and reducing oral health-r...

Abstract Background Localised renal cell carcinoma is treated with radical nephrectomy (RN) or partial nephrectomy (PN). Nephron-sparing PN increases preservation of renal function, reducing incidence of end stage renal ...

Abstract Background Belgium’s emergency services face several public health challenges, including increasing patient numbers and a shortage of medical staff. Against this backdrop, there is a risk that current organisa...

Abstract Immune checkpoint inhibitors (ICIs) have fundamentally altered the therapeutic paradigm for head and neck squamous cell carcinoma (HNSCC); however, durable clinical benefit remains limited to biologically define...

Abstract The early diagnosis of leprosy remains challenging in low-endemic regions. However, the implementation of clinical pathways (CPs) to improve diagnostic accuracy and understand patterns of misdiagnosis and delaye...

Agile approaches have received organisation acceptance as effective frameworks for managing complicated projects in rapidly changing situations. This study explores the challenges of agile adaptation in product team moti...