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Abstract The most difficult hurdles associated with the treatment of gynecologic cancer (such as ovarian, cervical, and endometrial cancer) is chemoresistance, with ovarian cancer representing the most clinically challen...

Evidence links pesticides to nonalcoholic fatty liver disease (NAFLD), but the combined effects of dietary pesticide residue mixture exposure on NAFLD remain poorly documented. This study employed a 42-day subchronic exp...

Abstract Background Fermented milk products are part of the staple diet for many Mediterranean populations. Most of these traditional foods are enriched with lactobacilli and other lactic acid bacteria, as well as with m...

Given the widespread application of copper oxide nanoparticles (CuONPs), their biosafety has attracted significant attention. However their effects on the developmental capacity of mammalian preimplantation embryos and t...

Community-acquired pneumonia (CAP) remains a major global public health challenge with substantial morbidity and mortality. Although preclinical studies suggest that Maxing Huoqiao (MXHQ) granule may have therapeutic pot...

Abstract Purpose Triple-negative breast cancer (TNBC) displays an aggressive clinicopathological profile. Despite cytotoxic chemotherapy being the primary systemic therapy, complete responses are achieved in fewer than 3...

Soil is a living, finite resource that shapes chemical fate, microbial ecology, nutrient supply, and climate regulation, yet environmental science and policy often treat it as an inert substrate. Approximately one-third ...

BackgroundChronic hepatitis B (CHB) caused by the hepatitis B virus (HBV) remains a major global health burden. The immune-active (IA) phase, characterized by positive Hepatitis B surface antigens (HBsAg), elevated alani...

Abstract Objective Based on the bidirectional communication mechanism of the gut-brain axis, this study aims to systematically elucidate the interactive pathways between gut microbiota and insomnia, review the research p...

Abstract “Miyamikhri,” a traditionally fermented bamboo shoot consumed by the Dimasa tribe of Assam, was investigated using a multi-omics approach integrating metagenomics, functional prediction, molecular docking, a...

Abstract Chronic pain is a multifactorial condition often accompanied by comorbidities such as anxiety, depression, and cardiovascular dysfunction. Traditional injury-based models have provided valuable mechanistic insig...

ABSTRACT Peripheral nerve regeneration continues to pose a significant clinical challenge, primarily attributable to the inherently limited regenerative capacity of axons and the intricate inflammatory microenvironment t...

Hepatic-driven metabolic alterations have impacts on both embryo implantation and subsequent fetal development. We previously found that dietary chenodeoxycholic acid (CDCA) improves maternal redox homeostasis and metabo...

Abstract Background Vascular calcification is a major pathological process driving cardiovascular morbidity and mortality, yet effective therapies are lacking. This study aims to identify novel causal plasma proteins and...

Abstract JMJD6, a bifunctional epigenetic modulator within the Jumonji C family, has garnered increasing attention for its potential roles in tumorigenesis, yet its pan-cancer prognostic and mechanistic significance rema...

Abstract Inflammatory diseases remain a major clinical challenge due to their complex pathologies and the limitations of current anti-inflammatory therapies. Conventional treatments, such as non-steroidal anti-inflammato...

Abstract Cardiovascular disease remains the leading cause of death and disability worldwide. The convergence of big data and artificial intelligence (AI) is reshaping precision cardiovascular medicine through multimodal ...

With the rapid growth of electronic health records, medical imaging, and high-throughput omics data, precision oncology faces increasing demands for cross-modal information integration and complex clinical decision suppo...

IntroductionMetabolism-associated fatty liver disease (MAFLD) has emerged as a severe worldwide public health burden with insufficient available clinical therapeutic strategies, which underscores the urgent demand for sa...

Abstract Background The impacts of social isolation on diverse health conditions and how it contributes to health risks remain unclear. We aimed to investigate the associations of social isolation with 59 health conditio...

Background: Outer membrane vesicles (OMVs) from Gram-negative bacteria are spherical lipid bilayer nanostructures with diameters of 20 to 250 nm. Porphyromonas gingivalis (P. gingivalis), a keystone periodontal pathogen,...

Sensorineural hearing loss (SNHL) is a major cause of disability worldwide, characterized by irreversible damage to cochlear hair cells and spiral ganglion neurons. Current treatments such as hearing aids and cochlear im...

Nonsyndromic orofacial clefts (NSOC) are common congenital craniofacial developmental defects. Current evidence suggests that genetic factors, environmental exposures, and their interactions jointly contribute to the dev...

Abstract Background After resection surgery, recurrence occurs in more than 30% of colorectal cancer (CRC) patients. Previous studies have highlighted the role of the gut microbiota in CRC initiation and progression; how...