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The complement system is a mediator and marker of renal damage. There are three pathways of complement activation: classical, alternative and lectin pathway. Lectin pathway is initiated by binding of mannose-binding lect...

IntroductionThe immune system is recognized as participating in the pathophysiology of psychiatric disease and there is renewed interest in identifying biomarkers of this immune activation. MethodsWe measured serum and c...

Abstract Background Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, and its diagnosis remains controversial due to heterogeneous phenotypes and varying diagnostic criteria. Insulin resista...

ABSTRACT Background and Aims May–Thurner Syndrome (MTS) is a rare vascular condition characterized by the compression of the left iliac vein by the overlying right iliac artery. This anatomical anomaly predisposes pati...

Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with rising global prevalence. Current management strategies predominantly address behavioral symptoms rather than core neurobi...

Endometriosis is a chronic, estrogent-dependent, inflammatory disease affecting a plethora of women of reproductive age and is a major cause of pelvis pain and subfertility. Current treatments – surgery and hormonal su...

Chronic limb-threatening ischemia (CLTI) represents the most severe form of peripheral artery disease, with high risks of infection, tissue loss, amputation, and mortality. Continuous or high-frequency monitoring could i...

Abstract Mirror syndrome is a rare disease with unknown pathophysiology that can be present in different diseases that can cause fetal hydrops. The prognosis is usually bad with a high perinatal mortality. We report an u...

Background and Aim: Cerebral ischemia is a major neurological condition that contributes significantly to global morbidity and mortality. It occurs due to reduced blood supply to the brain, leading to neuronal injury and...

Neurodegenerative disorders represent a major and growing global health challenge, characterized by progressive neuronal loss, multifactorial pathophysiology, and limited disease-modifying pharmacological options. Increa...

BackgroundGranulomatous-lymphocytic interstitial lung disease (GLILD) is a major cause of morbidity and mortality in common variable immunodeficiency (CVID), yet its pathophysiology remains incompletely understood, and n...

Lucie Bartova,1 Mara Lisa Beuster,2 Bruno Bonetti,3 Giuseppe Maina,4,5 Pedro Morgado,6 Johan Nyberg7 1Department of Psychiatry and Psychotherapy, Clinical Division of General Psychiatry, and Comprehensive Center for Clin...

Carotid artery stenting (CAS) has emerged as an effective alternative to carotid endarterectomy for treating carotid artery stenosis, particularly in high-risk surgical patients. However, in-stent restenosis (ISR) remain...

Introduction and purpose. Plantar fascia is a structure ensuring proper stabilization of the foot. Its malfunction impacts the organism as a whole. Untreated pathology leads to further health consequences. Plantar fascii...

Brain-Derived Neurotrophic Factor (BDNF) is the most abundant neurotrophin in the central nervous system with essential roles in neurodevelopment and maintenance of healthy brain function. Accordingly, BDNF has been sugg...

Abstract IgG4-related disease (IgG4-RD) is a systemic inflammatory condition marked by tissue infiltration of IgG4-positive plasma cells, often resulting in fibrosis. While IgG4-RD commonly affects organs such as the pan...

Patients with end-stage-renal disease (ESRD) experience a high cardiovascular mortality and cardiovascular risk factors such as obesity, hyperlipidemia and hypertension are very common. Recent epidemiological research ha...

ObjectivePolycystic ovary syndrome (PCOS) is a complex endocrine disorder. In this study, we characterize serum bile acids (BAs) metabolic profiles in PCOS patients using targeted metabolomics and investigated their corr...

Gitelman syndrome (GS) is a rare hereditary kidney disorder characterized by electrolyte abnormalities. However, its systemic manifestations, such as growth retardation, suggest broader metabolic disturbances. To investi...

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic condition characterized by hepatic fat accumulation and systemic metabolic dysfunction. MASLD exhibits clear sex differenc...

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disease characterized by heterogeneous symptom patterns. Previous work suggested that specific symptoms tend t...

ABSTRACT Background and Aim Post‐acute sequelae of SARS‐CoV‐2 infection (PASC), commonly referred to as long COVID, has emerged as a significant global health concern, marked by persistent symptoms and chronic infl...

Abstract Background Heart failure with preserved ejection fraction is the fastest-growing subtype of heart failure, especially among the elderly. Aim It is aimed to determine whether the addition of 10 mg of Dapaglifloz...

The purpose of research. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, characterized by metabolic, hormonal, reproductive, and psychological disturbances. Its pa...