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Background: Renal cell carcinoma (RCC) is a highly heterogeneous malignancy lacking reliable prognostic biomarkers and effective therapeutic targets. TMEM72, a kidney-enriched protein, is dysregulated in RCC, yet its bio...

Objective: To profile telomere-related genes (TRGs) to develop a robust prognostic tool for stomach adenocarcinoma (STAD) and explore their associations with immune regulation and treatment response. Methods: A total of ...

ObjectiveThe prognostic implications of surgical outcomes in older adults with ovarian cancer remain unclarified. This study aimed to describe temporal trends in surgical management and examine the association between su...

Background23-Hydroxybetulinic acid (23-HBA), a key bioactive compound in the traditional Chinese herb Pulsatilla chinensis, has garnered substantial scientific interest due to its potent antitumor activity. However, the ...

Aleksander Kielbik,1– 3 Veronika Bahlinger,3,4 Christian M Schürch,3,4 Maria Luisa Barcena,2 Olesya Vakhrusheva,2 Anita Thomas,5 Igor Tsaur,2 Jonas S Heitmann,1,3 Helmut R Salih,1,3,6 Ilona Hagelstein1,3,6 1Clinical C...

Abstract Background Cervicovaginal microbiota dysbiosis has been implicated in the progression of cervical cancer. Recent studies have reported an increased abundance of Porphyromonas species in the vaginal microbiota of...

BackgroundEstrogen receptor (ER)-low human epidermal growth factor receptor 2 (HER2)-negative breast cancer shares similar pathological and molecular features with triple-negative breast cancer, yet the utility of the 21...

Abstract Glioblastoma Multiforme (GBM) remains one of the most challenging malignancies to treat due to its aggressive proliferation, resistance to apoptosis, extensive angiogenesis, and capacity to evade conventional th...

In enzootic bovine leukosis (EBL), a B-cell lymphoma caused by bovine leukemia virus (BLV) infection, immune remodeling within tumor-affected lymph nodes is currently poorly understood. Here, we analyzed chemokine produc...

Abstract Prostate cancer (PCa) is a leading malignancy in men, particularly challenging in its advanced stages due to treatment resistance and immune evasion. MicroRNA-1290 (miR-1290) was identified to be implicated in t...

Abstract Background CSNK1D is a member of the CK1 family and is characterized by high conservation and widespread expression. It plays a regulatory role in the maintenance of numerous cellular processes and is expressed ...

BackgroundImmune checkpoint blockade (ICB) has improved outcomes for a subset of colorectal cancer (CRC) patients, yet the cellular determinants that drive heterogeneous treatment responses remain insufficiently understo...

Abstract Angiogenesis and its maturation play a crucial role in the progression and prognosis of head and neck squamous cell carcinoma (HNSCC). Tumor growth relies on an adequate blood supply to meet metabolic demands, w...

Glioblastoma (GBM) is the most common and aggressive type of central nervous system cancer, characterized by high rates of recurrence and mortality. As the highest-grade glioma, patient prognosis remains poor despite mul...

Latar Belakang. Operasi bedah pemotongan mandibula pada kasus tumor jinak maupun tumor ganas dapat menyebabkan deviasi mandibula. Tindakan perawatan bedah tergantung pada lokasi dan perluasan tumor mandibula, tindakan pe...

ABSTRACT Mutation‐intolerant genes (MIGs), which are constrained in tumors yet variable in normal tissues, are critical for cancer survival. Herein, we developed miDriver, a computational framework using pancancer‐no...

Latar belakang. Ameloblastoma dapat menyebabkan kerusakan pada tulang wajah baik pada maksila maupun mandibula. Tumor ini dapat mengalami rekurensi apabila perawatan tidak sempurna. Reseksi pada tulang yang terkena adala...

OBJETIVO: analisar o diagnóstico, evolução e conduta terapêutica em cinco casos de tumores cardíacos primários diagnosticados no período pré-natal. MÉTODOS: no período de Janeiro 1997 a Dezembro 2008, 7.989 ges...

Abstract Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and poses a significant threat to public health. Traditional treatments often lead to poor prognoses and tum...

Abstract Tumor-associated B (TAB) cells and plasma cells are increasingly recognized as key components of the tumor microenvironment; however, their heterogeneity and functional roles in breast cancer remain incompletely...

Para que se produzcan procesos de proliferación celular, tanto en tejidos normales como tumorales, es necesaria la presencia de vasos sanguíneos. La formación de estos se realiza a través de un complicado proceso den...

En los seres humanos, los tumores del intestino grueso constituyen una causa importante de morvilidad y mortalidad en gran parte del mundo. Factores dietéticos y del medio ambiente son considerados como responsables del...

Tesis de Doctorado El bloqueo de los puntos de control como CTLA-4 y PD-1/PD-L1 ha demostrado la actividad de efectores inmunes antitumorales, por lo que ha aumentado el interés en el desarrollo de inmunoterapias contra...

En este trabajo se diseñó un método automático para la segmentación tridimensional del glioblastoma multiforme (GBM) con sus zonas internas de tumor activo, necrosis, y edema periférico difuso, combinando técnicas...